Ultrastructural changes of capillaries in chronic venous insufficiency
Abstract
The ultrastructural changes of cutaneous and subcutaneous capillaries and venules in 6 cases of severe, chronic venous insufficiency were examined. The findings in all cases consisted of numerous and characteristic alterations of the vessel wall structure and of the pericapillary space which are supposed to be due to the increased intravenous pressure. The intercellular spaces are enlarged to wide channels through which erythrocytes pass into the perivascular spaces. Microvesicles occur in great numbers, they are arranged in chain-like formations and seem to come together to form transendothelial channels. Around the capillaries, edematous fluid with proteins and erythrocytes accumulates. Phagocytosis of erythrocytes, siderosomes and collagen fibrils by macrophages is observed. Within the endothelial cells there is an abundance of Weibel-Palade bodies and of multivesicular bodies. The former are frequently seen in contact with the luminal cell membrane. Weibel-Palade bodies are believed to be involved in the clotting mechanism.
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Local iron overload in chronic venous disease is due to diapedesis of erythrocytes that enter the interstice through fenestrations in capillaries under conditions of chronic venous stasis.
“This is due to the diapedesis of erythrocytes that enter the interstice through fenestrations in the capillaries under conditions of chronic venous stasis.17”
From Hemochromatosis C282Y gene mutation increases the risk of venous leg ulceration (2005) · cites this paper as [17]
Heme catabolism at the interstitial level causes hemosiderin deposits at both the phagocyte and extracellular levels.
“The heme catabolism at the interstitial level causes hemosiderin deposits at both the phagocyte and extracellular levels (Fig 1).”
From Hemochromatosis C282Y gene mutation increases the risk of venous leg ulceration (2005) · cites this paper as [17]
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Cited by 52
- Authors
- Wenner, A., Leu, H. J., Spycher, M., & Brunner, U.
- Affiliations
- University of Zurich (CH)
- Venue
- Experimental Cell Biology
- Publisher
- S. Karger AG
- Published
- 2008-10-07
- Pages
- 1-14
- ISSN
- 0304-3568 (ISSN-L)
- 2235-1671
- OpenAlex
- W2044720719
- Cited by
- 52
- References
- 0
- Citations by year
- 2023: 2 · 2022: 1 · 2018: 1 · 2017: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Cell Biology (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Diagnosis and Treatment of Venous Diseases
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- chronic venous insufficiency, capillary ultrastructure, venules, pericapillary space, erythrocyte extravasation, microvesicles, transendothelial channels, macrophage phagocytosis, Weibel-Palade bodies, multivesicular bodies, endothelial cells
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