The effect of ventromedial hypothalamic lesions on metabolism and insulin secretion in rats on a controlled feeding regimen
Abstract
The metabolic effect of ventromedial hypothalamic (VMH) lesions, which are known to cause hyperphagia and obesity, has been studied in rats kept on a controlled light and food regimen. The animals were sacrificed at 4 different times during the second postoperative day. A feeding-induced hypersecretion of insulin was found in the VMH-lesioned animals. It was accompanied by a marked hypoglycemia as compared to the control groups during the feeding period. The glycogen content of liver and diaphragm in the lesioned groups is increased as compared to the controls during the same period. The VMH-lesioned animals showed hypertriglyceridemia both in the fed and fasted state, whereas the postabsorptive plasma levels of free fatty acids and glycerol were decreased. An increased level of urea was observed in all lesioned groups. This is in accordance with the demonstrated protein catabolism which follows VMH lesions.
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Spontaneous physical activity is reduced during development of ventromedial hypothalamic obesity and increased fat deposition occurs even with restriction of food intake to that of controls.
“Importantly, spontaneous physical activity is reduced during development of ventromedial hypothalamic obesity and increased fat deposition occurs even with restriction of food intake to that of controls.”
From The carbohydrate-insulin model: A physiological perspective on the obesity pandemic (2021) · cites this paper as [116]
Immediately after injury to the ventromedial hypothalamus, hyperinsulinemia develops without systemic insulin resistance, and sympathetic nervous system tone is decreased.
“Immediately after injury to the ventromedial hypothalamus, hyperinsulinemia develops without systemic insulin resistance, and sympathetic nervous system tone is decreased.”
From The carbohydrate-insulin model: A physiological perspective on the obesity pandemic (2021) · cites this paper as [116]
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Cited by 17
- Authors
- Hustvedt, B.-E., Løvø, A., & Reichl, D.
- Affiliations
- University of Oslo (NO)
- Venue
- Annals of Nutrition and Metabolism
- Publisher
- S. Karger AG
- Published
- 1976
- Volume
- 20
- Issue
- 4
- Pages
- 264-271
- ISSN
- 0250-6807 (ISSN-L)
- 1421-9697
- OpenAlex
- W2042683860
- Cited by
- 17
- References
- 0
- Citations by year
- 2024: 1 · 2021: 1
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Nutrition and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- ventromedial hypothalamus, hypothalamic lesions, insulin secretion, hyperphagia, obesity, hypoglycemia, glycogen, hypertriglyceridemia, free fatty acids, glycerol, urea, protein degradation, energy metabolism, rats
- MeSH terms
- Insulin Secretion, Animals, Blood Glucose, Darkness, Fasting, Fatty Acids, Nonesterified, Female, Glucose, Glycerol, Hypothalamus, Insulin, Light, Liver Glycogen, Triglycerides, Urea, Lipid Metabolism, Rats
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