Effect of a Long-Acting Somatostatin Analogue (SMS 201–995) on Postprandial Gastric Emptying of 99m Tc-Tin Colloid and Mouth-to-Caecum Transit Time in Man
Abstract
The effect on gut motility of a single subcutaneous injection of 50 micrograms of the long-acting somatostatin analogue, SMS 201-995, was investigated in 8 normal volunteers who took a drink containing 99mTc and lactulose with a mixed meal. The rate of gastric emptying was assessed by disappearance of the isotope from the stomach area as measured by a gamma camera, and mouth-to-caecum transit time (MCTT) was measured by the appearance of hydrogen in the breath. Gastric emptying was accelerated, with a significant reduction of the time taken to 50% isotope disappearance (37.2 +/- 3.3 min during control study vs 23.3 +/- 3.4 min after SMS injection; p less than 0.01). In contrast, MCTT was prolonged from 57.3 +/- 9.4 min (control) to 203.6 +/- 14.7 min after SMS (p less than 0.001).
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Somatostatin analogues target various steps in the pathophysiology of dumping syndrome, including delaying gastric emptying, delaying transit through the small intestine, inhibiting the release of GI hormones, inhibiting insulin secretion and inhibiting postprandial vasodilation.
“Somatostatin analogues target various steps in the pathophysiology of dumping syndrome, including delaying gastric emptying, delaying transit through the small intestine, inhibiting the release of GI hormones, inhibiting insulin secretion and inhibiting postprandial vasodilation (15,(67)(68)(69)(70)(71)(72)(73)(74)(75)(76)(77)(78).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [68]
No citation lists for this paper
No citation lists for this paper yet — checked again daily.
Cited by 89
- Authors
- Fuessl, H. S., Carolan, G., Williams, G., & Bloom, S. R.
- ORCID
- Williams, G.
- Venue
- Digestion
- Publisher
- S. Karger AG
- Published
- 2009-01-29
- Volume
- 36
- Issue
- 2
- Pages
- 101-107
- ISSN
- 0012-2823 (ISSN-L)
- 1421-9867
- OpenAlex
- W2057715521
- Cited by
- 89
- References
- 0
- Citations by year
- 2025: 1 · 2023: 4 · 2022: 1 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 3 · 2012: 1
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Digestion (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Core Research for Evolutional Science and Technology
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
- Keywords
- SMS 201-995, octreotide, somatostatin analogues, gastric emptying, intestinal motility, 99mTc-tin colloid, lactulose breath test, postprandial motility, subcutaneous injection
- MeSH terms
- Adult, Blood Glucose, Breath Tests, Gastric Emptying, Gastrointestinal Hormones, Gastrointestinal Motility, Humans, Hydrogen, Insulin, Male, Somatostatin, Technetium, Tin, Octreotide, Technetium Compounds, Tin Compounds
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
