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Enhancement of the Fibrinolytic Activity in Plasma by Oral Administration of Nattokinases
Abstract
The existence of a potent fibrinolytic enzyme (nattokinase, NK) in the traditional fermented food called 'natto', was reported by us previously. It was confirmed that oral administration of NK (or natto) produced a mild and frequent enhancement of the fibrinolytic activity in the plasma, as indicated by the fibrinolytic parameters, and the production of tissue plasminogen activator. NK capsules were also administered orally to dogs with experimentally induced thrombosis, and lysis of the thrombi was observed by angiography. The results obtained suggest that NK represents a possible drug for use not only in the treatment of embolism but also in the prevention of the disease, since NK has a proven safety and can be massproduced.
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Citations
Cited by
Bioactivity of soy-based fermented foods: A review
Cao, Z.-H., Green-Johnson, J. M., Buckley, N. D., & Lin, Q.-Y. (2019) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.12.001 · Cited by 231
A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles
Kurosawa, Y., Nirengi, S., Homma, T., Esaki, K., Ohta, M., Clark, J. F., & Hamaoka, T. (2015) · Scientific Reports · doi:10.1038/srep11601 · Cited by 115
Uesugi, Y., Kawata, H., Jo, J.-I., Saito, Y., & Tabata, Y. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.07.127 · Cited by 103
Nattokinase improves blood flow by inhibiting platelet aggregation and thrombus formation
Jang, J.-Y., Kim, T.-S., Cai, J., Kim, J., Kim, Y., Shin, K., Kim, K. S., Park, S. K., Lee, S.-P., Choi, E.-K., et al. (2013) · Laboratory Animal Research · doi:10.5625/lar.2013.29.4.221 · Cited by 77
Jensen, G., Lenninger, M., Ero, M. P., & Benson, K. (2016) · Integrated Blood Pressure Control · doi:10.2147/ibpc.s99553 · Cited by 71
Metadata
- Authors
- Sumi, H., Hamada, H., Nakanishi, K., & Hiratani, H.
- Venue
- Acta Haematologica
- Publisher
- S. Karger AG
- Published
- 1990
- Volume
- 84
- Issue
- 3
- Pages
- 139-143
- ISSN
- 0001-5792 (ISSN-L)
- 1421-9662
- OpenAlex
- W2074415411
- Cited by
- 304
- References
- 0
- FWCI
- 12.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sumi, H., Hamada, H., Nakanishi, K., & Hiratani, H. (1990). Enhancement of the Fibrinolytic Activity in Plasma by Oral Administration of Nattokinases. Acta Haematologica. https://doi.org/10.1159/000205051
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