Modulation of Paracetamol and Nefopam Antinociception by Serotonin 5-HT3 Receptor Antagonists in Mice
Abstract
Background/Aims: Post-operative nausea and vomiting are common adverse events that require administration of anti-emetic compounds, such as the serotonin 5-HT 3 receptor antagonists, but these drugs can also reduce the analgesic efficacy of some analgesics (paracetamol, tramadol). Methods: The present study was designed to explore the effect of 3 serotonin 5-HT 3 receptor antagonists on the antinociceptive efficacy of another frequently used post-operative analgesic, nefopam, in the mouse writhing and formalin tests. Results: Pre-treatment with tropisetron, ondansetron or MDL72222 did not significantly modify nefopam antinociception in both tests. However, paracetamol antinociception was blocked by ondansetron in the formalin test. Conclusion: These results provide a rationale for the clinical use of nefopam with anti-emetics during surgery.
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Selective blockade of particular serotonergic receptors abolishes the analgesic actions of paracetamol in acute models of pain.
“Decades of research have provided evidence on the significance of this pathway to mediate the analgesic action of paracetamol as it has been shown that selective blockade of particular serotonergic receptors to abolish the analgesic actions of paracetamol in acute models of pain.”
From Paracetamol (acetaminophen): A familiar drug with an unexplained mechanism of action (2021) · cites this paper as [75]
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References 24 · Cited by 21
- Authors
- Girard, P., Pansart, Y., Coppé, M.-C., Niedergang, B., & Gillardin, J.-M.
- Venue
- Pharmacology
- Publisher
- S. Karger AG
- Published
- 2009
- Volume
- 83
- Issue
- 4
- Pages
- 243-246
- ISSN
- 0031-7012 (ISSN-L)
- 1423-0313
- OpenAlex
- W2085387615
- Cited by
- 21
- References
- 24
- Citations by year
- 2021: 4 · 2020: 2 · 2017: 1 · 2014: 3 · 2013: 1 · 2012: 2
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Surgery › Anesthesia and Pain Management
- Health Sciences › Medicine › Surgery › Nausea and vomiting management
- Keywords
- 5-HT3 receptor antagonists, paracetamol, nefopam, antinociception, postoperative analgesia, ondansetron, tropisetron, postoperative nausea and vomiting, antiemetics, analgesic interaction, formalin test, writhing test
- MeSH terms
- Tropisetron, Acetaminophen, Analgesics, Animals, Drug Interactions, Indoles, Male, Mice, Inbred Strains, Nefopam, Pain Measurement, Serotonin Antagonists, Ondansetron, Acetic Acid, Mice, Serotonin 5-HT3 Receptor Antagonists
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