The DOI matches its Crossref record.
Penicillin concentrations in serum following weekly injections of benzathine penicillin G.
Abstract
Twelve patients with syphilis were treated weekly with injections of 1.44 g (2.4 X 10(6) IU) of benzathine penicillin G for up to 3 weeks. Almost daily, serum penicillin concentrations were measured by a sensitive microbiological agar cup method. An individual and interindividual variation was found. Concentrations below the recommended 0.018 micrograms/ml were found 7 days after the first or second injection in 5 samples. Shorter intervals between injections are recommended.
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“Pharmacologic considerations indicate that an interval of 7–9 days between doses, if feasible, might be preferred (610–612).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [611]
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Cited by
Sexually Transmitted Infections Treatment Guidelines, 2021
Workowski, K. A., Bachmann, L. H., Chan, P. A., Johnston, C. M., Muzny, C. A., Park, I., Reno, H., Zenilman, J. M., & Bolan, G. A. (2021) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr7004a1 · Cited by 3,018
Sexually Transmitted Diseases Treatment Guidelines, 2010
Workowski, K., & BOLAN, G. A. (2011) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2011.04.006 · Cited by 2,074
Syphilis during pregnancy: a preventable threat to maternal-fetal health
Rac, M. W. F., Revell, P. A., & Eppes, C. S. (2016) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2016.11.1052 · Cited by 146
Ramchandani, M. S., Cannon, C. A., & Marra, C. M. (2023) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2023.02.006 · Cited by 66
Ghanem, K. G. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ714 · Cited by 55
Li, Y., Okayama, A., Hagi, T., Muto, C., Raber, S., & Nagashima, M. (2024) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.2454 · Cited by 5
“26,27,29,30 In our study, participants were confined to the research unit for 2 days after injection of BPG with almost normal activity levels but without strenuous exercise.”
Johnson, K. A., Burghardt, N., Snyder, R. E., Plotzker, R. E., Imp, B. M., Murphy, R., Jacobson, K. R., & Tang, E. C. (2023) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofad300 · Cited by 3
Zhao, X., & Ishizaki, T. (1999) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357991776705 · Cited by 2
Birru, E. M., Salman, S., Page‐Sharp, M., Baye, C., Manning, L., Moore, B. R., & Batty, K. T. (2026) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkag145
Metadata
- Authors
- Hagdrup, H. K., Wantzin, L., Secher, L., & Rosdahl, T.
- Affiliations
- Rigshospitalet (DK)
- University of Copenhagen (DK)
- Venue
- Chemotherapy
- Publisher
- S. Karger AG
- Published
- 2009-09-09
- Volume
- 32
- Issue
- 2
- Pages
- 99-101
- ISSN
- 0009-3157 (ISSN-L)
- 1421-9794
- OpenAlex
- W2040388813
- Cited by
- 9
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2021: 1 · 2016: 1 · 2015: 1
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemotherapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Antibiotics Pharmacokinetics and Efficacy
- Health Sciences › Medicine › Infectious Diseases › Syphilis Diagnosis and Treatment
- Health Sciences › Medicine › Pharmacology (medical) › Historical Medical Research and Treatments
- Keywords
- benzathine penicillin G, syphilis, pharmacokinetics, interindividual variability, dosing interval
- MeSH terms
- Absorption, Adult, Drug Administration Schedule, Female, Humans, Injections, Intramuscular, Male, Middle Aged, Penicillin G, Penicillin G Benzathine, Syphilis
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