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Effect of a Low Protein Diet during Pregnancy on the Fetal Rat Endocrine Pancreas
Abstract
The administration of a low protein (LP, 8% protein/dry matter) but isocaloric diet to gestating rats did not affect their fertility, but slightly reduced the quantity of food intake as well as body weight gain. The LP diet also did not affect the placental weight, but the weight of the offspring was decreased. Accordingly the fetal endocrine pancreas was altered by the LP diet. Two different morphometric analyses showed that in the LP neonate B-cell proliferation and islet size were reduced in the head of the pancreas. In the pancreatic tail, these parameters were also decreased but to a lesser extend. Islet vascularization in the neonates was dramatically reduced in both parts of the pancreas when the mothers were fed with the LP diet.
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Citations
Cited by
Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis
Hales, C. N., & Barker, D. J. P. (1992) · Diabetologia · doi:10.1007/bf00400248 · Cited by 3,309
Fetal nutrition and cardiovascular disease in adult life
Barker, D. J. P., Godfrey, K. M., Gluckman, P. D., Harding, J. E., Owens, J. A., & Robinson, J. S. (1993) · The Lancet · doi:10.1016/0140-6736(93)91224-a · Cited by 2,753
Developmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming
Mcmillen, I. C., & Robinson, J. S. (2005) · Physiological Reviews · doi:10.1152/physrev.00053.2003 · Cited by 1,910
Glucose tolerance in adults after prenatal exposure to famine
Ravelli, A., van der Meulen, J., Michels, R., Osmond, C., Barker, D., Hales, C., & Bleker, O. (1998) · The Lancet · doi:10.1016/s0140-6736(97)07244-9 · Cited by 1,606
Early Developmental Conditioning of Later Health and Disease: Physiology or Pathophysiology?
Hanson, M. A., & Gluckman, P. D. (2014) · Physiological Reviews · doi:10.1152/physrev.00029.2013 · Cited by 1,188
Metadata
- Authors
- Snoeck, A., Remacle, C., Reusens, B., & Hoet, J. J.
- Venue
- Neonatology
- Publisher
- S. Karger AG
- Published
- 1990
- Volume
- 57
- Issue
- 2
- Pages
- 107-118
- ISSN
- 0006-3126 (ISSN-L)
- 1661-7800
- 1661-7819
- OpenAlex
- W2024672438
- Cited by
- 652
- References
- 0
- FWCI
- 32.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Effect of a Low Protein Diet during Pregnancy on the Fetal Rat Endocrine Pancreas. https://app.cochat.ai/papers/10.1159/000243170
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- Snoeck, A., Remacle, C., Reusens, B., & Hoet, J. J. (1990). Effect of a Low Protein Diet during Pregnancy on the Fetal Rat Endocrine Pancreas. Neonatology. https://doi.org/10.1159/000243170
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.