Water-based versus alcohol-based benzoyl peroxide preparations in the treatment of acne vulgaris
Abstract
Forty-eight patients with acne vulgaris in the face were treated with a water-based (Basiron®) and an alcohol-based (Panoxyl®) 5% benzoyl peroxide preparation. A randomized double-blind, contralateral study was used. No difference in clinical effect was found. Treatment for 8 weeks resulted in at least 50% reduction in the number of closed comedones, papules and pustules in over 80% of the patients. In more than 70% of the patients, the reduction exceeded 75%. The water-based Basiron caused significantly less skin irritation than the alcohol-based preparation of Panoxyl.
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Benzoyl peroxide at lower concentrations and in water-based or wash-off formulations may be tolerated better.
“Lower BP concentrations and water-based and wash-off formulations may be better tolerated.166,167”
From Guidelines of care for the management of acne vulgaris (2024) · cites this paper as [166]
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Guidelines of care for the management of acne vulgaris
Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., Bowe, W. P., Graber, E. M., Harper, J. C., Kang, S., et al. (2016) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2015.12.037 · Cited by 1,597 · see citing works
Guidelines of care for the management of acne vulgaris
Reynolds, R. V., Yeung, H., Cheng, C. E., Cook-Bolden, F., Desai, S. R., Druby, K. M., Freeman, E. E., Keri, J. E., Stein Gold, L. F., Tan, J. K. L., et al. (2024) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2023.12.017 · Cited by 518 · see citing works
- Authors
- Fyrand, O., & Bang Jakobsen, H.
- Affiliations
- Oslo University Hospital (NO)
- Corresponding author
- Fyrand, Ole
- Venue
- Dermatologica
- Publisher
- S. Karger AG
- Published
- 2009-10-13
- Volume
- 172
- Issue
- 5
- Pages
- 263-267
- ISSN
- 0011-9075 (ISSN-L)
- 2571-7197
- OpenAlex
- W2014792685
- Cited by
- 25
- References
- 0
- Citations by year
- 2024: 1 · 2023: 3 · 2021: 1 · 2020: 2 · 2016: 2 · 2015: 1 · 2014: 3 · 2012: 1
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Dermatologica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Infectious Diseases › Dermatological diseases and infestations
- Keywords
- acne, benzoyl peroxide, water-based formulations, topical treatment, comedones, papules and pustules, skin irritation
- MeSH terms
- Acne Vulgaris, Administration, Topical, Adolescent, Adult, Ethanol, Benzoyl Peroxide, Clinical Trials as Topic, Dermatitis, Contact, Double-Blind Method, Erythema, Female, Gels, Humans, Male, Peroxides, Random Allocation, Water
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