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Pregnancy in Women with Congenital Antithrombin III Deficiency: Experience of Treatment with Heparin and Antithrombin

Hellgren, Margareta, Tengbom, Lilian, Abildgaard, Urlich·1982·Gynecologic and Obstetric Investigation

Abstract

The incidence of thromboembolic complications (TE) during pregnancy in women with congenital antithrombin III (AT) deficiency has retrospectively been estimated to be about 70%. 8 women with congenital AT deficiency were studied during 9 pregnancies. Subcutaneous or intravenous heparin in doses to prolong the activated partial thromboplastin time (APTT) was given during pregnancy as prophylaxis or therapeutic treatment. During delivery and abortion the AT level was brought to normal by infusion of AT concentrate and the heparin was reduced or withdrawn. Four pregnancies were uncomplicated with regard to TE and resulted in 4 healthy children. Five pregnancies were terminated by induced or spontaneous abortion. 1 woman had TE during heparin prophylaxis and 2 women had TE before the prophylaxis was started. 1 of the latter suffered from a new TE during continued heparing treatment. Insufficient prolongation of APTT was registered at the time of TE in both women with TE during heparin treatment.

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Metadata

Authors
Hellgren, M., Tengbom, L., & Abildgaard, U.
Venue
Gynecologic and Obstetric Investigation
Publisher
S. Karger AG
Published
1982
Volume
14
Issue
2
Pages
127-141
ISSN
  • 0378-7346 (ISSN-L)
  • 1423-002X
OpenAlex
W2009932827
Cited by
158
References
0
FWCI
2.33
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Pregnancy in Women with Congenital Antithrombin III Deficiency: Experience of Treatment with Heparin and Antithrombin. https://app.cochat.ai/papers/10.1159/000299460
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Hellgren, M., Tengbom, L., & Abildgaard, U. (1982). Pregnancy in Women with Congenital Antithrombin III Deficiency: Experience of Treatment with Heparin and Antithrombin. Gynecologic and Obstetric Investigation. https://doi.org/10.1159/000299460

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.