The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Episodes of Overtreatment during the First Six Months in Children with Congenital Hypothyroidism and Their Relationships with Sustained Attention and Inhibitory Control at School Age
Abstract
BACKGROUND/AIMS: Contradictory results regarding the optimal initial dose of levothyroxine in children with congenital hypothyroidism (CH) hamper the clinical management of these children during their early infancy. We explore the relationships between the initial dose of levothyroxine and endocrine control during the first 6 months and cognition at school age. SUBJECTS AND METHODS: Fifty children with CH, 14 boys (10+/-3.1 years) and 36 girls (9.7+/-2.6 years), at the Pediatric Endocrine Unit of the Hospital Gregorio Marañón in Madrid were studied. Neurocognitive evaluation was carried out exploring alertness and inhibitory control. The number of episodes of overtreatment during the first 6 months, the initial dose of levothyroxine, etiology and sex were the predictor variables. RESULTS: Inhibitory control was significantly lower in children with CH than in controls. An interaction with gender and etiology was obtained. Alertness had an inverse relationship with the number of episodes of overtreatment with no interaction with gender or etiology. CONCLUSION: Episodes of overtreatment and not the initial dose of levothyroxine are a risk factor for deficit in alertness whereas subtle inhibitory control deficit seems to be a permanent problem with the current therapeutic approach.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Overtreatment during the first months of life (with the exception of fT4 above the normal range with not supressed TSH and/or without signs or symptoms of hyperthyroidism), a critical period for brain development, may be associated with attention deficit at the school age (109,171,172), and lower IQ scores (108,173,174).”
Citations
Cites
Brain development in children and adolescents: Insights from anatomical magnetic resonance imaging
Lenroot, R. K., & Giedd, J. N. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.06.001 · Cited by 1,863
Development of attentional networks in childhood
Rueda, M. R., Fan, J., McCandliss, B. D., Halparin, J. D., Gruber, D. B., Lercari, L. P., & Posner, M. I. (2004) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2003.12.012 · Cited by 1,339
Toga, A. W., Thompson, P. M., & Sowell, E. R. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.01.007 · Cited by 872
Update of Newborn Screening and Therapy for Congenital Hypothyroidism
Rose, S. R., Brown, R. S., & Lawson Wilkins Pediatric Endocrine Society (2006) · PEDIATRICS · doi:10.1542/peds.2006-0915 · Cited by 801
Thyroid hormone receptors in brain development and function
Bernal, J. (2007) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0424 · Cited by 718
BURGESS, P. W., ALDERMAN, N., FORBES, C., COSTELLO, A., M-A.COATES, L., DAWSON, D. R., ANDERSON, N. D., GILBERT, S. J., DUMONTHEIL, I., & CHANNON, S. (2006) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617706060310 · Cited by 663
Zoeller, R. T., & Rovet, J. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2004.01243.x · Cited by 605
Thyroid hormones states and brain development interactions
Ahmed, O. M., El‐Gareib, A. W., El-Bakry, A. M., El-Twab, S. M. A., & Ahmed, R. G. (2007) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2007.09.011 · Cited by 345
Selva, K. A., Harper, A., Downs, A., Blasco, P. A., & LaFranchi, S. H. (2005) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2005.07.024 · Cited by 190
Anatomy of attentional networks
Raz, A. (2004) · The Anatomical Record Part B The New Anatomist · doi:10.1002/ar.b.20035 · Cited by 186
Tillotson, S. L., Fuggle, P. W., Smith, I., Ades, A. E., & Grant, D. B. (1994) · BMJ · doi:10.1136/bmj.309.6952.440 · Cited by 177
Oerbeck, B., Sundet, K., Kase, B. F., & Heyerdahl, S. (2003) · Pediatrics · doi:10.1542/peds.112.4.923 · Cited by 176
Salerno, M., Militerni, R., Bravaccio, C., Micillo, M., Capalbo, D., Di Maio, S., & Tenore, A. (2002) · Thyroid · doi:10.1089/105072502753451968 · Cited by 165
The Functional Integration of the Anterior Cingulate Cortex during Conflict Processing
Fan, J., Hof, P. R., Guise, K. G., Fossella, J., & Posner, M. I. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm125 · Cited by 160
Executive attention and self-regulation in infancy
Sheese, B. E., Rothbart, M. K., Posner, M. I., White, L. K., & Fraundorf, S. H. (2008) · Infant Behavior and Development · doi:10.1016/j.infbeh.2008.02.001 · Cited by 156
Bongers-Schokking, J. J., & de Muinck Keizer-Schrama, S. M. P. F. (2005) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2005.09.031 · Cited by 131
Simoneau-Roy, J., Marti, S., Deal, C., Huot, C., Robaey, P., & Van Vliet, G. (2004) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2004.02.021 · Cited by 123
Dimitropoulos, A., Molinari, L., Etter, K., Torresani, T., Lang-Muritano, M., Jenni, O. G., Largo, R. H., & Latal, B. (2009) · Pediatric Research · doi:10.1203/pdr.0b013e31818d2030 · Cited by 114
Children With Congenital Hypothyroidism and Their Siblings: Do They Really Differ?
Rovet, J. F. (2005) · Pediatrics · doi:10.1542/peds.2004-1492 · Cited by 98
Thyroid Development and Effect on the Nervous System
Santisteban, P., & Bernal, J. (2005) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-005-3053-9 · Cited by 85
Kempers, M. J. E., van der Sluijs Veer, L., Nijhuis-van der Sanden, R. W. G., Lanting, C. I., Kooistra, L., Wiedijk, B. M., Last, B. F., de Vijlder, J. J. M., Grootenhuis, M. A., & Vulsma, T. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1538 · Cited by 85
Building a Clinically Relevant Cognitive Task: Case Study of the AX Paradigm
MacDonald, A. W. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn038 · Cited by 78
Congenital Hypothyroidism: Developmental Outcome in Relation to Levothyroxine Treatment Variables
Heyerdahl, S., & Oerbeck, B. (2003) · Thyroid · doi:10.1089/105072503770867200 · Cited by 73
Molecular insight into the effects of hypothyroidism on the developing cerebellum
Dong, H., Wade, M., Williams, A., Lee, A., Douglas, G. R., & Yauk, C. L. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.099 · Cited by 72
Neuronal representation of occluded objects in the human brain
Olson, I. R., Gatenby, J. C., Leung, H., Skudlarski, P., & Gore, J. C. (2003) · Neuropsychologia · doi:10.1016/s0028-3932(03)00151-9 · Cited by 64
Molecular genetic defects in congenital hypothyroidism
Grüters, A., Krude, H., & Biebermann, H. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.151u039 · Cited by 62
Thyroid Hormone and Attention in Congenital Hypothyroidism
Rovet, J., & Alvarez, M. (1996) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.1996.9.1.63 · Cited by 50
Thyroid Hormone and Attention in School‐Age Children with Congenital Hypothyroidism
ROVET, J. F., & Alvarez, M. (1996) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1996.tb01444.x · Cited by 48
Boileau, P., Bain, P., Rives, S., & Toublanc, J. (2004) · Hormone Research in Paediatrics · doi:10.1159/000076597 · Cited by 47
Perceived Shifts of Flashed Stimuli by Visible and Invisible Object Motion
Watanabe, K., Sato, T., & Shimojo, S. (2003) · Perception · doi:10.1068/p5047 · Cited by 34
Oerbeck, B., Reinvang, I., Sundet, K. S., & Heyerdahl, S. (2007) · Scandinavian Journal of Psychology · doi:10.1111/j.1467-9450.2006.00545.x · Cited by 31
High versus low dose of initial thyroid hormone replacement for congenital hypothyroidism
Ng, S. M., Anand, D., & Weindling, A. M. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006972.pub2 · Cited by 30
A new response-time measure of object persistence in the tunnel effect
Kawachi, Y., & Gyoba, J. (2006) · Acta Psychologica · doi:10.1016/j.actpsy.2006.04.003 · Cited by 25
Delvecchio, M., Faienza, M. F., Acquafredda, A., Zecchino, C., Peruzzi, S., & Cavallo, L. (2007) · Hormone Research in Paediatrics · doi:10.1159/000100373 · Cited by 21
Alvarez, M., Carvajal, F., Renon, A., Pérez, C. D. R. P., Olivares, A., Rodríguez, G., & Álvarez, V. A. (2003) · Hormone Research in Paediatrics · doi:10.1159/000075192 · Cited by 20
An Investigation of Impulsivity in Children With Early-Treated Congenital Hypothyroidism
Kooistra, L., Vulsma, T., & van der Meere, J. (2004) · Developmental Neuropsychology · doi:10.1207/s15326942dn2602_4 · Cited by 14
Marti, S., Alvarez, M., Simoneau‐Roy, J., Leroux, S., Vliet, G. V., & Robaey, P. (2006) · Hormone Research in Paediatrics · doi:10.1159/000095069 · Cited by 14
Estado neurocognitivo en niños de 8 años con hipotiroidismo congénito tratado precozmente
González, M. Á. Á., Güell, R., Daniel, L., et al. (1999) · Revista de Neurología · doi:10.33588/rn.2807.98227 · Cited by 12
González, M. Á. Á., Martínez, F. C., Gesen, C. P., et al. (2004) · Revista de Neurología · doi:10.33588/rn.3806.2003396 · Cited by 9
Alvarez, M. A., Guell, R., Gonzalez, J., Seuc, A. H., Perez, H. C., Robaina, R., & Fernández-Yero, J. L. (1992) · Screening · doi:10.1016/0925-6164(92)90012-t · Cited by 9
[Early development and learning conditions: the role of the executive functions].
Sastre-Riba, S. (2006) · PubMed · Cited by 9
Ahmed, O. M., El‐Gareib, A. W., El-Bakry, A. M., et al. (2008) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2008.09.003 · Cited by 8
LAFRANCHI, S. H. (2008) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0970 · Cited by 7
Tratamiento del hipotiroidismo
Arnao, M. D. R., Sánchez, A. R., Cabarcos, A. P., & Arnao, J. R. (2002) · Anales de Pediatría · Cited by 6
Torres, A. O., Gesen, C. P., ́nez, F. C. M., et al. (2008) · Clinical Neurophysiology · doi:10.1016/j.clinph.2008.04.241 · Cited by 1
Cited by
Sorted by citations
Léger, J., Olivieri, A., Donaldson, M., Torresani, T., Krude, H., van Vliet, G., Polak, M., Butler, G., & on behalf of ESPE-PES-SLEP-JSPE-APEG-APPES-ISPAE, A. T. C. H. C. C. G. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1891 · Cited by 569
van Trotsenburg, P., Stoupa, A., Léger, J., Rohrer, T., Peters, C., Fugazzola, L., Cassio, A., Heinrichs, C., Beauloye, V., Pohlenz, J., et al. (2021) · Thyroid® · doi:10.1089/thy.2020.0333 · Cited by 469
Bongers-Schokking, J. J., Resing, W. C. M., de Rijke, Y. B., de Ridder, M. A. J., & de Muinck Keizer-Schrama, S. M. P. F. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2175 · Cited by 94
Léger, J. (2015) · European Journal of Endocrinology · doi:10.1530/eje-14-0777 · Cited by 72
Cassio, A., Monti, S., Rizzello, A., Bettocchi, I., Baronio, F., D'Addabbo, G., Bal, M. O., & Balsamo, A. (2013) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2012.11.070 · Cited by 68
Metadata
- Authors
- Álvarez, M., Iglesias Fernández, C., Rodríguez Sánchez, A., Dulín ĺñiguez, E., & Rodríguez Arnao, M. D.
- Affiliations
- University of Havana (CU)
- Venue
- Hormone Research in Paediatrics
- Publisher
- S. Karger AG
- Published
- 2010
- Volume
- 74
- Issue
- 2
- Pages
- 114-120
- ISSN
- 1663-2818 (ISSN-L)
- 1663-2826
- OpenAlex
- W1991787302
- Cited by
- 57
- References
- 45
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 7 · 2018: 6 · 2017: 6 · 2016: 4 · 2015: 6 · 2014: 5 · 2013: 3 · 2012: 1
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormone Research in Paediatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Keywords
- congenital hypothyroidism, overtreatment, levothyroxine, initial dose, hormonal regulation, sustained attention, alertness, inhibitory control, neuropsychological outcomes, elementary school students, thyroid hormone replacement
- MeSH terms
- Child, Congenital Hypothyroidism, Dose-Response Relationship, Drug, Female, Humans, Infant, Male, Thyrotropin, Thyroxine, Linear Models, Hormone Replacement Therapy, Executive Function
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review