Effect of Levothyroxine Suppression Therapy on Plasma Thrombin Activatable Fibrinolysis Inhibitor Antigen Levels in Benign Thyroid Nodules
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Objective: The aim of this prospective study was to investigate the effect of LT4 suppression therapy on plasma thrombin activatable fibrinolysis inhibitor (TAFI) antigen and plasminogen activator inhibitor-1 (PAI-1) levels in benign thyroid nodules. We also compared hyperthyroid patients and healthy controls. Subjects and Methods: Twenty premenopausal women with benign thyroid nodules were given LT4 suppression therapy for 1 year. Plasma TAFI and PAI-1 antigen levels were measured at baseline and after LT4 suppression treatment. The endogenous hyperthyroid group was composed of 19 premenopausal females with newly diagnosed endogenous hyperthyroidism. Eighteen age-matched euthyroid healthy premenopausal women were enrolled as the control group. Results: TAFI antigen levels decreased after LT4 suppression treatment; however, the difference was not statistically significant (p = 0.057). LT4 treatment resulted in a nonsignificant increase in PAI-1 levels. Patients with endogenous hyperthyroidism had decreased levels of TAFI antigen and increased levels of PAI-1 antigen (p < 0.05). There was a negative correlation between the FT 4 and TAFI antigen levels. Serum TSH was positively correlated with the plasma levels of TAFI antigen. Conclusion: LT4 suppression therapy for benign thyroid nodules did not result in a significant decrease in TAFI antigen levels in premenopausal women, but endogenous hyperthyroidism was associated with significantly decreased levels of TAFI antigen.
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Thyrotoxicosis induced by administration of LT4 to healthy volunteers and those with thyroid nodules induces a procoagulant state, associated with increased levels of FVIII, FIX, FX, VWF, fibrinogen D-dimer, and PAI-1 with delayed fibrin clot lysis and a shortening of the APTT, but with an inconsistent impact on clot structure parameters.
“Thyrotoxicosis induced by administration of LT4 to healthy volunteers and those with thyroid nodules also induces a procoagulant state, associated with increased levels of FVIII, FIX, FX, VWF, fibrinogen D-dimer, and PAI-1 with delayed fibrin clot lysis and a shortening of the APTT, but with an inconsistent impact on clot structure parameters”
From Pharmacodynamic and Therapeutic Actions of Levothyroxine (2021) · cites this paper as [118]
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References 27 · Cited by 7
- Authors
- Akinci, B., Demir, T., Comlekci, A., Yener, S., Ozcan, M. A., Karaoglu, O., Yuksel, F., Secil, M., & Yesil, S.
- Venue
- Medical Principles and Practice
- Publisher
- S. Karger AG
- Published
- 2010-12-13
- Volume
- 20
- Issue
- 1
- Pages
- 23-28
- ISSN
- 1011-7571 (ISSN-L)
- 1423-0151
- OpenAlex
- W1965298622
- Cited by
- 7
- References
- 27
- Citations by year
- 2022: 1 · 2021: 1 · 2018: 2 · 2017: 1 · 2012: 2
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Medical Principles and Practice (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- levothyroxine suppression therapy, thrombin-activatable fibrinolysis inhibitor, plasminogen activator inhibitor-1, benign thyroid nodules, thyroid-stimulating hormone, free thyroxine, premenopausal women, coagulation and fibrinolysis
- MeSH terms
- Adult, Analysis of Variance, Antigens, Enzyme-Linked Immunosorbent Assay, Female, Goiter, Nodular, Humans, Hyperthyroidism, Middle Aged, Prospective Studies, Thyroxine, Triiodothyronine, Ultrasonography, Case-Control Studies, Thyroid Nodule, Plasminogen Activator Inhibitor 1, Premenopause, Carboxypeptidase B2
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