A Phase II Study of Combined Chemotherapy with 5-Week Cycles of S-1 and CPT-11 plus Bevacizumab in Patients with Metastatic Colon Cancer

Mizushima, Tsunekazu; Ide, Yoshito; Murata, Kohei; Ohashi, Ichiro; Yasumasa, Keigo; Fukunaga, Mutsumi; Takemoto, Hiroyoshi; Tamagawa, Hiroshi; Hasegawa, Junichi; Hata, Taishi; Takemasa, Ichiro; Ikeda, Masataka; Yamamoto, Hirofumi; Sekimoto, Mitsugu; Nezu, Riichiro; Doki, Yuichiro; Mori, Masaki; on behalf of the Clinical Study Group of Osaka University (CSGO), Colorectal Group

doi:10.1159/000356018

A Phase II Study of Combined Chemotherapy with 5-Week Cycles of S-1 and CPT-11 plus Bevacizumab in Patients with Metastatic Colon Cancer

Objective: Combined chemotherapy with S-1 and irinotecan (IRIS) for metastatic colorectal cancer has been reported to be effective and safe. However, there are only a few studies on the effects of adding bevacizumab to IRIS. We conducted a clinical study to evaluate the efficacy and safety of IRI…