The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Genotypes and Genetic Variability of Hepatitis B Virus
Open accessAbstract
Sequence heterogeneity is a feature of hepatitis B virus (HBV), the prototype member of the family Hepadnaviridae. Based on an intergroup divergence of greater than 7.5% across the complete genome, HBV has been classified phylogenetically into 9 genotypes, A-I, with a putative 10th genotype ‘J', isolated from a single individual. With between approximately 4 and 8% intergroup nucleotide divergence across the complete genome and good bootstrap support, genotypes A-D, F, H, and I are classified further into subgenotypes. There is a broad and highly statistically significant correlation between serological subtypes and genotypes, and in some cases, serological subtypes can be used to differentiate subgenotypes. The genotypes, and certain subgenotypes, have distinct geographical distributions and are important in both the clinical manifestation of infection and response to antiviral therapy. HBV genotypes/subgenotypes and genetic variability of HBV are useful in epidemiological and transmission studies, tracing human migrations, and in predicting the risk for the development of severe liver disease and response to antiviral therapy. Moreover, knowledge of the genotype/subgenotype is important in implementing preventative strategies. Thus, it is crucial that new strains are correctly assigned to their respective genotype/subgenotype and consistent, unambiguous, and generally accepted nomenclature is utilized.
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Cites
Norder, H., Couroucé, A.-M., Coursaget, P., Echevarria, J. M., Lee, S.-D., Mushahwar, I. K., Robertson, B. H., Locarnini, S., & Magnius, L. O. (2004) · Intervirology · doi:10.1159/000080872 · Cited by 868
Okada, K., Kamiyama, I., Inomata, M., Imai, M., Miyakawa, Y., & Mayumi, M. (1976) · New England Journal of Medicine · doi:10.1056/nejm197604012941402 · Cited by 728
Hepatitis B e antigen-negative chronic hepatitis B
Hadziyannis, S. J., & Vassilopoulos, D. (2001) · Hepatology · doi:10.1053/jhep.2001.27834 · Cited by 554
Chu, C., Hussain, M., & Lok, A. S. F. (2002) · Gastroenterology · doi:10.1053/gast.2002.33588 · Cited by 460
Kramvis, A., Kew, M., & François, G. (2005) · Vaccine · doi:10.1016/j.vaccine.2004.10.045 · Cited by 394
Self-citationExploring the Biological Basis of Hepatitis B E Antigen in Hepatitis B Virus Infection
Milich, D., & Liang, J. T. (2003) · Hepatology · doi:10.1053/jhep.2003.50453 · Cited by 393
Liu, S., Zhang, H., Gu, C., Yin, J., He, Y., Xie, J., & Cao, G. (2009) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djp180 · Cited by 388
Epidemiology of hepatitis B virus in Africa, its genotypes and clinical associations of genotypes
Kramvis, A., & Kew, M. C. (2007) · Hepatology Research · doi:10.1111/j.1872-034x.2007.00098.x · Cited by 347
Self-citationMcMahon, B. J. (2009) · Hepatology International · doi:10.1007/s12072-008-9112-z · Cited by 267
Livingston, S. E., Simonetti, J. P., Bulkow, L. R., Homan, C. E., Snowball, M. M., Cagle, H. H., Negus, S. E., & McMahon, B. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.08.010 · Cited by 256
Cited by
Schillie, S., Vellozzi, C., Reingold, A., Harris, A., Haber, P., Ward, J. W., & Nelson, N. P. (2018) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr6701a1 · Cited by 815
“Infection or immunization with one genotype generally confers immunity to all genotypes (7,44,46,47).”
Background
Metadata
- Authors
- Kramvis, A.
- Venue
- Intervirology
- Publisher
- S. Karger AG
- Published
- 2014
- Volume
- 57
- Issue
- 3-4
- Pages
- 141-150
- ISSN
- 0300-5526 (ISSN-L)
- 1423-0100
- OpenAlex
- W1991040699
- Cited by
- 462
- References
- 30
- FWCI
- 21.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
