Sexual difference in bone geometry of adult patients with classical congenital adrenal hyperplasia: data using peripheral quantitative computed tomography
Abstract
BACKGROUND/AIMS: Glucocorticoid treatment may influence bone and muscle development in patients with congenital adrenal hyperplasia (CAH). This study evaluated bone mineral density (BMD), bone geometry and muscle mass. METHODS: 73 adult patients with classical CAH were followed. BMD, bone geometry and muscle mass were measured using peripheral quantitative computed tomography (pQCT). Glucocorticoid-equivalent doses throughout life were calculated and at the time pQCT androgen levels were measured. RESULTS: In males the mean standard deviation (SD) score for trabecular BMD (-0.33 ± 0.71) was reduced, whereas mean cortical BMD (1.05 ± 1.11) was elevated. Mean total (0.86 ± 1.12) and medullary cross-sectional area (CSA; 1.12 ± 1.17) were significantly increased (p < 0.001). In all patients SD scores for cortical thickness (-0.65 ± 0.91) and muscle CSA (-0.83 ± 0.91) were reduced. Treatment duration was associated with lower trabecular BMD in males (r = -0.63, p < 0.001). Suppressed androgens and simple virilizing CAH had an adverse effect on the muscle CSA SD score (OR 0.58 and 0.46, respectively, p < 0.05). CONCLUSION: There was a sexual difference with enlarged total and medullary CSA in females, whereas in males trabecular BMD was reduced and cortical BMD elevated. Cortical thickness and muscle CSA were reduced in all CAH patients with a possible long-term impact on bone development and stability. Monitoring of bone and muscle development might be warranted.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Bone density is increased in women with CAH with variably elevated serum testosterone when it is only partially suppressed by glucocorticoid treatment, although more effective glucocorticoid suppression lowers bone density.
“Bone density (total and medullary cross-sectional area) is increased in women with CAH with variably elevated serum testosterone (including into the male range) when it is only partially suppressed by glucocorticoid treatment (143), although more effective glucocorticoid suppression lowers bone density (144).”
From Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance (2018) · cites this paper as [143]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 34 · Cited by 7
Research works printed but not linked: 3
- Brandt I, Reinken L: The growth rate of healthy children in the first 16 years: Bonn- Dortmund Longitudinal Developmental Study (in German). Klin Padiatr 1988; 200: 451-456.
- Greulich WW, Pyle SI: Radiographic Atlas of Skeletal Development of the Hand and Wrist, ed 2. Palo Alto, Stanford University Press, 1958.
- Akaike H: Information measures and model selection. Bull Int Stat Inform 1983; 70: 14.
- Authors
- Bechtold, S., Beyerlein, A., Bonfig, W., Dalla Pozza, R., Putzker, S., Otto, R., Schmidt, H., & Schwarz, H. P.
- Affiliations
- Ludwig-Maximilians-Universität München (DE)
- Helmholtz Munich (DE)
- Corresponding author
- Bechtold, Susanne
- Venue
- Hormone Research in Paediatrics
- Publisher
- S. Karger AG
- Published
- 2014
- Volume
- 82
- Issue
- 3
- Pages
- 171-178
- ISSN
- 1663-2818 (ISSN-L)
- 1663-2826
- OpenAlex
- W2039471983
- Cited by
- 7
- References
- 34
- Citations by year
- 2025: 1 · 2023: 1 · 2018: 3 · 2017: 1 · 2016: 1
- FWCI
- 0.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormone Research in Paediatrics (publishedVersion)
- PubMed (publishedVersion)
- Open access LMU (Ludwid Maxmilian's Universitat Munchen) (submittedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- classical congenital adrenal hyperplasia, bone geometry, bone mineral density, muscle mass, sex differences, glucocorticoid therapy, treatment duration, trabecular bone, cortical bone, cross-sectional area, androgen deprivation therapy, skeletal development
- MeSH terms
- Adolescent, Adrenal Hyperplasia, Congenital, Adult, Anthropometry, Bone and Bones, Female, Hormones, Humans, Male, Organ Size, Sex Characteristics, Steroid 21-Hydroxylase, Tomography, X-Ray Computed, Cohort Studies, Bone Density, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
