A prospective study on how symptoms in a network predict the onset of depression
Open accessAbstract
To explain the overt heterogeneous nature of major depressive disorder (MDD), it could be valuable to focus on individual symptoms [1]. Recent research, for example, showed that MDD symptoms differ in their underlying biology, risk factors and psychosocial impairments [for a review, see [2]]. In addition, the presence of specific symptoms (e.g. psychomotor agitation) may have important clinical implications, such as expectations regarding the response to antidepressants [3].
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Depression and anxiety are associated with both a lack of motivation and impaired concentration, making such users a particular challenge to engage.
“This is especially important for DMHIs designed to address depression and anxiety since these conditions are associated with both a lack of motivation (84) and impaired concentration (85), making such users a particular challenge to engage.”
From What Works and What Doesn’t Work? A Systematic Review of Digital Mental Health Interventions for Depression and Anxiety in Young People (2019) · cites this paper as [85]
The study reports concentration problems as a central MDD symptom and a strong predictor of depression onset (results, p. 184), supporting the depression-related part of the claim attached to citation 85. It does not establish impaired concentration in anxiety. The separate citation for lack of motivation and the citing authors’ inference about engagement are not judged here. (LLM, conf=0.85)
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References 10 · Cited by 213
Research works printed but not linked: 1
- Fried EI, Boschloo L, van Borkulo CD, Schoevers RA, Romeijn JW, Wichers M, De Jonge P, Nesse RM, Tuerlinckx F, Borsboom D: Com- mentary: 'consistent superiority of selective serotonin reuptake inhibi- tors over placebo in reducing depressed mood in patients with depres- sion'. Front Psychiatry 2015; 6: 117.
- Authors
- Boschloo, L., van Borkulo, C. D., Borsboom, D., & Schoevers, R. A.
- Affiliations
- University Medical Center Groningen (NL)
- Venue
- Psychotherapy and Psychosomatics
- Publisher
- S. Karger AG
- Published
- 2016
- Volume
- 85
- Issue
- 3
- Pages
- 183-184
- ISSN
- 0033-3190 (ISSN-L)
- 1423-0348
- OpenAlex
- W2323994370
- Cited by
- 213
- References
- 10
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 24 · 2023: 19 · 2022: 20 · 2021: 32 · 2020: 22 · 2019: 24 · 2018: 25 · 2017: 21 · 2016: 10
- FWCI
- 37.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Psychotherapy and Psychosomatics (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion, cc-by-nc-nd)
- VU Research Portal (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- major depressive disorder, depression onset, symptom networks, symptom heterogeneity, psychomotor agitation, antidepressant response, risk factors
- MeSH terms
- Depression, Major Depressive Disorder, Follow-Up Studies, Humans, Prospective Studies, Psychiatric Status Rating Scales, Risk Factors, Logistic Models, Case-Control Studies
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