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Paul Ehrlich (1854-1915) and His Contributions to the Foundation and Birth of Translational Medicine
Open accessAbstract
Translational research and precision medicine are based on a profound knowledge of cellular and molecular mechanisms contributing to various physiologic processes and pathologic reactions in diverse organs. Whereas specific molecular interactions and mechanisms have been identified during the past 5 decades, the underlying principles were defined much earlier and originate from to the seminal observations made by outstanding researchers between 1850 and 1915. One of the most outstanding exponents of these scientists is Paul Ehrlich. His work resulted not only in the foundation and birth of modern hematology and immunology, but also led to the development of chemotherapy and specific targeted treatment concepts. In 2015, the Medical University of Vienna organized a memorial meeting, with the aim of honoring Paul Ehrlich's contributions to science, and to commemorate the 100th anniversary of his death. The authors of the current review served as faculty members and dedicate this paper to Paul Ehrlich and his remarkable contributions to medicine.
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Cites
Beiträge zur Kenntniss der Anilinfärbungen und ihrer Verwendung in der mikroskopischen Technik
Ehrlich, P. (1877) · Archiv für Mikroskopische Anatomie · doi:10.1007/bf02933937 · Cited by 334
Sneader, W. (2005) · Cited by 302
Bosch, F., & Rosich, L. (2008) · Pharmacology · doi:10.1159/000149583 · Cited by 292
Kaufmann, S. H. E. (2008) · Nature Immunology · doi:10.1038/ni0708-705 · Cited by 292
The Composition of Ehrlich's Salvarsan: Resolution of a Century‐Old Debate
Lloyd, N. C., Morgan, H. W., Nicholson, B. K., & Ronimus, R. S. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200461471 · Cited by 256
Schwartz, R. S. (2004) · New England Journal of Medicine · doi:10.1056/nejmp048021 · Cited by 221
Paul Ehrlich — in search of the magic bullet
Winau, F., Westphal, O., & Winau, R. (2004) · Microbes and Infection · doi:10.1016/j.micinf.2004.04.003 · Cited by 164
A History of the Use of Arsenicals in Man
Jolliffe, D. (1993) · Journal of the Royal Society of Medicine · doi:10.1177/014107689308600515 · Cited by 118
Paul Ehrlich's doctoral thesis: a milestone in the study of mast cells
Enrico Crivellato, B., Beltrami, C. A., Mallardi, F., & Ribatti, D. (2003) · British Journal of Haematology · doi:10.1046/j.1365-2141.2003.04573.x · Cited by 110
Paul Ehrlich: founder of chemotherapy
Kaufmann, S. H. E. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2582 · Cited by 104
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Demystifying theory and its use in improvement
Davidoff, F., Dixon-Woods, M., Leviton, L., & Michie, S. (2015) · BMJ Quality & Safety · doi:10.1136/bmjqs-2014-003627 · Cited by 714
Neutralizing monoclonal antibodies for treatment of COVID-19
Taylor, P. C., Adams, A. C., Hufford, M. M., de la Torre, I., Winthrop, K., & Gottlieb, R. L. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00542-x · Cited by 732
Molecular targeted therapy for anticancer treatment
Min, H.-Y., & Lee, H.-Y. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00864-3 · Cited by 569
Origin of microglia: current concepts and past controversies
Ginhoux, F., & Prinz, M. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020537 · Cited by 446
More friend than foe: the emerging role of neutrophils in tissue repair
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Metadata
- Authors
- Valent, P., Groner, B., Schumacher, U., Superti-Furga, G., Busslinger, M., Kralovics, R., Zielinski, C., Penninger, J. M., Kerjaschki, D., Stingl, G., Smolen, J. S., Valenta, R., Lassmann, H., Kovar, H., Jäger, U., Kornek, G., Müller, M., & Sörgel, F.
- Venue
- Journal of Innate Immunity
- Publisher
- S. Karger AG
- Published
- 2016
- Volume
- 8
- Issue
- 2
- Pages
- 111-120
- ISSN
- 1662-811X (ISSN-L)
- 1662-8128
- OpenAlex
- W2256634634
- Cited by
- 409
- References
- 19
- FWCI
- 24.97
- Type
- journal article
- Language
- en
- Open access
- gold
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- Valent, P., Groner, B., Schumacher, U., Superti-Furga, G., Busslinger, M., Kralovics, R., Zielinski, C., Penninger, J. M., Kerjaschki, D., Stingl, G., Smolen, J. S., Valenta, R., Lassmann, H., Kovar, H., Jäger, U., Kornek, G., Müller, M., & Sörgel, F. (2016). Paul Ehrlich (1854-1915) and His Contributions to the Foundation and Birth of Translational Medicine. Journal of Innate Immunity. https://doi.org/10.1159/000443526
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.