Diet-Induced Weight Loss Reduces DNA Damage and Cardiometabolic Risk Factors in Overweight/Obese Women with Polycystic Ovary Syndrome
Open accessAbstract
Aims: We aimed to investigate the impact of following a diet to induce weight loss (500 kcal deficit per day) over DNA damage and cardiometabolic risk factors in women with overweight/obesity diagnosed with polycystic ovary syndrome (PCOS). Methods: A study was conducted in Natal, RN, Brazil selecting overweight/obese (body mass index ≥25 and <39 kg/m 2) women (18-35 years). The levels of DNA damage were assessed by a single cell gel electrophoresis. Repeated 24 h dietary recall questionnaires, anthropometry, biochemical profile and sex hormones were collected at baseline and after 12 weeks of intervention. Results: Women exhibiting a decrease in the markers of DNA damage: tail intensity (24.35 ± 5.86 - pre diet vs. 17.15 ± 5.04 - post-diet; p < 0.001) and tail moment (20.47 ± 7.85 - pre diet vs. 14.13 ± 6.29 - post-diet; p < 0.002). Reduction of calorie intake, weight loss, decreased sexual hormone and cardiometabolic markers such as insulin, homeostasis model assessment of insulin resistance and low-density lipoprotein cholesterol were verified In the multivariate regression analysis, quantitative insulin sensitivity check index and progesterone were responsible for the variation markers in DNA damage before the diet, losing its influence upon diet. Conclusion: DNA damage and the impact of cardiometabolic risk factors decreased after the intervention in women with PCOS, indicating the relevance of a nutritional approach in this group of patients.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A 500 kcal/d deficit was sufficient for an average weight loss of 3.5% that was significantly associated with a reduction in fasting blood glucose, plasma insulin, and LDL-C concentrations, as well as HOMA-IR.
“a 500 kcal/d deficit was also sufficient for an average weight loss of 3.5% that was significantly associated with a reduction in fasting blood glucose, plasma insulin, and LDL-C concentrations, as well as HOMA-IR [71].”
From Moving beyond Weight: A Narrative Review of the Dietary and Lifestyle Management for Reducing Cardiometabolic Risk in Polycystic Ovary Syndrome (PCOS) (2023) · cites this paper as [71]
The citation lists haven’t been fetched yet
References 61 · Cited by 31
- Authors
- Soares, N. P., Santos, A. C. S. D., Costa, E. C., Azevedo, G. D., Damasceno, D. C., Fayh, A. P. T., & Lemos, T. M. A. M.
- Affiliations
- Universidade Federal do Rio Grande do Norte (BR)
- Universidade Estadual Paulista (Unesp) (BR)
- ORCID
- Venue
- Annals of Nutrition and Metabolism
- Publisher
- S. Karger AG
- Published
- 2016
- Volume
- 68
- Issue
- 3
- Pages
- 220-227
- ISSN
- 0250-6807 (ISSN-L)
- 1421-9697
- OpenAlex
- W2338795385
- Cited by
- 31
- References
- 61
- Citations by year
- 2026: 4 · 2024: 1 · 2023: 6 · 2022: 1 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 1 · 2017: 5 · 2016: 1
- FWCI
- 4.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Nutrition and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, cc-by-nd)
- Americanae (AECID Library) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nd)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Apoio à Pesquisa do Rio Grande do Norte
- Ministério da Saúde
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- polycystic ovary syndrome, weight loss diet, caloric restriction, DNA damage, cardiometabolic risk factors, insulin resistance, insulin sensitivity, sex hormones, progesterone, LDL cholesterol, overweight women, obesity
- MeSH terms
- Adolescent, Adult, Brazil, Cardiovascular Diseases, Diet, Reducing, DNA Damage, Female, Humans, Hyperlipidemias, Insulin Resistance, Obesity, Patient Dropouts, Polycystic Ovary Syndrome, Risk Factors, Biomarkers, Weight Loss, Body Mass Index, Comet Assay, Metabolic Syndrome, Overweight, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
