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Cited by 30Pancreatic and Hepatic Oncology ResearchPancreatitis Pathology and TreatmentNeuroendocrine Tumor Research Advances

The Clinical Outcomes after Total Pancreatectomy

Suzuki, Shuji, Kajiyama, Hideki, Takemura, Akira, Shimazaki, Jiro, Nishida, Kiyotaka, Shimoda, Mitsugi·2017·Digestive Surgery
DOI 10.1159/000449234
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Abstract

Background: Total pancreatectomy (TP) is not more beneficial than less aggressive resection techniques for the treatment of pancreatic neoplasms and is associated with high morbidity and mortality. However, with advances in surgical techniques and glycemic monitoring, and the development of synthetic insulin and pancreatic enzymes for postoperative treatment, TP has been increasingly indicated. This is a review of the recent literature reporting the clinical outcomes after TP. Methods: We reviewed the publications reporting the use of TP starting 2007. The clinicophysiological and survival data were analyzed. Results: Few studies evaluated the differences in clinical outcomes between TP and pancreaticoduodenectomy (PD) with inconsistent results. It was reported that while the perioperative morbidity did not decrease, the mortality decreased compared to previous literature. All patients who underwent TP required insulin and high dose of pancreatic enzyme supplements. The 5-year survival rates after TP and PD for pancreatic cancer were similar. Conclusion: The perioperative mortality decreased in patients who underwent TP with advances in the operative procedures and perioperative care. The long-term survival rates were similar for TP and PD. Therefore, treating pancreatic neoplasms using TP is feasible. Patients undergoing TP should receive adequate treatment with synthetic insulin and pancreatic enzyme supplements.

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Cited by

Sorted by citations

Authors
Suzuki, S., Kajiyama, H., Takemura, A., Shimazaki, J., Nishida, K., & Shimoda, M.
Affiliations
Tokyo Medical University (JP)
Corresponding author
Suzuki, Shuji
ORCID
Venue
Digestive Surgery
Publisher
S. Karger AG
Published
2016-10-05
Volume
34
Issue
2
Pages
142-150
ISSN
  • 0253-4886 (ISSN-L)
  • 1421-9883
DOI
10.1159/000449234
OpenAlex
W2528573053
Cited by
30
References
0
Citations by year
2026: 1 · 2023: 6 · 2022: 4 · 2021: 2 · 2020: 6 · 2019: 7 · 2018: 1 · 2017: 2 · 2016: 1
FWCI
0.37
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Digestive Surgery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
  • Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
  • Health Sciences › Medicine › Epidemiology › Neuroendocrine Tumor Research Advances
Keywords
total pancreatectomy, pancreatic cancer, pancreaticoduodenectomy, perioperative mortality, postoperative morbidity, insulin therapy, pancreatic enzyme replacement therapy, long-term survival, pancreatic neoplasms
MeSH terms
Humans, Insulin, Pancreatectomy, Pancreatic Neoplasms, Survival Rate, Pancreaticoduodenectomy, Treatment Outcome, Patient Selection, Dietary Supplements, Enzyme Therapy

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