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Fibroblast Growth Factor 23 and Hypophosphatemia: A Case of Hypophosphatemia along the Rickets-Osteomalacia Spectrum

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Georges, George T., Nájera, O., Sowers, Kurt, Sowers, James R.·2017·Cardiorenal Medicine

Abstract

Phosphorus is a key component of bone, and a deficiency results in poor mineralization along with other systemic symptoms of hypophosphatemia. Various causes of hypophosphatemia with renal wasting of phosphorus have been identified. These include the Fanconi syndrome, various genetic mutations of fibroblast growth factor 23 (FGF23) handling and the sodium/phosphate cotransporter, and those due to FGF23 secretion by mesenchymal tumors. Depending on the cause, vitamin D metabolism may also be impaired, which may amplify the deficiency in phosphorus and render treatment more challenging. Here, we report a case of hypophosphatemia and multiple stress fractures in a 20-year-old male college student living with chronic bone pain and anxiety about suffering further fractures. We further review the literature regarding this spectrum.

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Metadata

Authors
Georges, G. T., Nájera, O., Sowers, K., & Sowers, J. R.
Venue
Cardiorenal Medicine
Publisher
S. Karger AG
Published
2016-09-30
Volume
7
Issue
1
Pages
60-65
ISSN
  • 1664-3828 (ISSN-L)
  • 1664-5502
OpenAlex
W2527550773
Cited by
680
References
0
FWCI
57.56
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Fibroblast Growth Factor 23 and Hypophosphatemia: A Case of Hypophosphatemia along the Rickets-Osteomalacia Spectrum. https://app.cochat.ai/papers/10.1159/000449476
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Georges, G. T., Nájera, O., Sowers, K., & Sowers, J. R. (2017). Fibroblast Growth Factor 23 and Hypophosphatemia: A Case of Hypophosphatemia along the Rickets-Osteomalacia Spectrum. Cardiorenal Medicine. https://doi.org/10.1159/000449476

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.