Energy Metabolism and Ageing in the Mouse: A Mini-Review
Abstract
The mouse has rapidly become the mammalian model organism of choice in ageing research due to its relatively short lifespan, the proximity of its genome and physiology to humans, and most importantly due to its genetic pliability and the availability of mutant strains. Mouse models have provided great insights into the ageing process, which in its broadest sense is the progressive decline of body functions over time. In this mini-review, we briefly cover the historical views on the link between ageing and metabolic rate, highlight genetically modified transgenic mouse models of extended lifespan, discuss endocrine pathways linked to senescence and ageing, and then examine pathways by which caloric restriction is postulated to result in longevity.
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These advantages make mice an excellent model for studying the aging process and investigating potential interventions and treatments for age-related conditions.
“These advantages make mice an excellent model for studying the aging process and investigating potential interventions and treatments for age-related conditions.297”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [297]
The mouse has several advantages for aging research, including its relatively short lifespan compared to humans, the close similarity of its genome and physiology to humans, and the ease with which its genetics can be manipulated.
“This is primarily attributed to several factors, including its relatively short lifespan compared to humans, the close similarity of its genome and physiology to humans, and the ease with which its genetics can be manipulated, including the availability of various mutant strains.”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [297]
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References 62 · Cited by 90
- Authors
- Azzu, V., & Valencak, T. G.
- Affiliations
- University of Cambridge (GB)
- University of Veterinary Medicine Vienna (AT)
- Venue
- Gerontology
- Publisher
- S. Karger AG
- Published
- 2017
- Volume
- 63
- Issue
- 4
- Pages
- 327-336
- ISSN
- 0304-324X (ISSN-L)
- 1423-0003
- OpenAlex
- W2582155201
- Cited by
- 90
- References
- 62
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 10 · 2023: 7 · 2022: 18 · 2021: 18 · 2020: 16 · 2019: 6 · 2018: 4 · 2017: 3
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- aging, energy metabolism, metabolic rate, lifespan extension, transgenic mouse model, genetic modification, endocrine pathways, senescence, caloric restriction, longevity
- MeSH terms
- Aging, Animals, Energy Metabolism, Biological Evolution, Fatty Acids, Humans, Longevity, Mice, Mutant Strains, Mice, Transgenic, Models, Animal, Caloric Restriction, Mice, Metabolic Networks and Pathways
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