The DOI matches its Crossref record.
An Experimental Model of Alcohol Feeding and Liver Injury in the Baboon
Abstract
A model has been developed for the administration to the baboon of ethanol as part of a nutritionally adequate liquid diet. With this regimen, all animals maintained their weight, and liver morphology was normal in the controls. Isocaloric substitution of carbohydrate (50% of total calories) by ethanol resulted in the production of fatty liver in all animals, while some also developed alcoholic hepatitis and cirrhosis with increased activities of serum glutamic oxaloacetic transaminase. Inebriation and manifestation of dependence upon withdrawal of the diet were observed. Chemical alterations produced by ethanol at the fatty liver stage were characterized by striking triglyceride accumulation and enhanced activities of microsomal enzymes, including the microsomal ethanol oxidizing system (MEOS).
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Citations
Cited by
Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis
Lieber, C. S. (2004) · Alcohol · doi:10.1016/j.alcohol.2004.07.008 · Cited by 699
Self-citationS –Adenosyl–L–Methionine Attenuates Alcohol–Induced Liver Injury in the Baboon
Lieber, C. S., Casini, A., Decarli, L. M., Kim, C.-I., Lowe, N., Sasaki, R., & Leo, M. A. (1990) · Hepatology · doi:10.1002/hep.1840110203 · Cited by 326
Self-citationAlcoholic liver disease: pathogenesis and new targets for therapy
Altamirano, J., & Bataller, R. (2011) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2011.134 · Cited by 284
Alcoholic liver disease: New insights in pathogenesis lead to new treatments
Lieber, C. S. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80420-1 · Cited by 260
Self-citationMechanism of ethanol induced hepatic injury
Lieber, C. S. (1990) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(90)90032-w · Cited by 168
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Metadata
- Authors
- Lieber, C. S., & DeCarli, L. M.
- Venue
- Journal of Medical Primatology
- Publisher
- S. Karger AG
- Published
- 1974
- Volume
- 3
- Issue
- 3
- Pages
- 153-163
- ISSN
- 0047-2565 (ISSN-L)
- 1600-0684
- OpenAlex
- W2410885163
- Cited by
- 231
- References
- 0
- FWCI
- 6.10
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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