Enteroendocrine Cells: Metabolic Relays between Microbes and Their Host
Abstract
Gut bacteria exert a variety of metabolic functions unavailable to the host and are increasingly seen as a virtual organ located inside our gastrointestinal tract. Scattered in our intestinal epithelium, enteroendocrine cells (EECs) regulate several aspects of the host's physiology and translate signals coming from the gut microbiota through their hormonal secretions. In this chapter, we will assess the interplay between the gut microbiota and EEC and its consequences for the physiology of the host. We will first describe alterations of different populations of EEC in germ-free animals. The role of mediators of this interaction, such as microbial metabolites and their receptors will also be discussed. Finally, different strategies harnessing host-microbe crosstalk for therapeutic purposes will be presented with an emphasis on obesity and related disorders.
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Changing the fermentation capacity of the gut microbiota through chronic dietary supplementation of prebiotics or probiotics was successful in decreasing food intake, body weight and improving glucose tolerance in preclinical models of obesity and diabetes.
“Changing the fermentation capacity of the gut microbiota through chronic dietary supplementation of prebiotics or probiotics was quite successful in decreasing food intake, body weight and improving glucose tolerance in preclinical models of obesity and diabetes (see Tables 4, 5; for further details, see review (Plovier and Cani, 2017)).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Plovier and Cani, 2017
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References 185 · Cited by 36
- Authors
- Plovier, H., & Cani, P. D.
- Affiliations
- Walloon Excellence in Lifesciences and Biotechnology (BE)
- Venue
- Endocrine Development
- Publisher
- S. Karger AG
- Published
- 2017
- Volume
- 32
- Pages
- 139-164
- ISSN
- 1421-7082 (ISSN-L)
- 1662-2979
- OpenAlex
- W2750425508
- Cited by
- 36
- References
- 185
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 6 · 2021: 4 · 2020: 9 · 2019: 9 · 2018: 2
- FWCI
- 6.80
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Endocrine development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- enteroendocrine cells, gut microbiota, host-microbe crosstalk, microbial metabolites, germ-free animals, intestinal epithelium, gastrointestinal hormones, obesity, obesity-related disorders, treatment options
- MeSH terms
- Gastrointestinal Microbiome, Animals, Humans, Obesity, Enteroendocrine Cells, Gastrointestinal Tract, Metabolic Networks and Pathways, Host-Pathogen Interactions
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