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Inflammation in Diabetic Kidney Disease
Abstract
Background: Diabetes is a growing public health problem. Diabetic kidney disease (DKD) is the most prevalent chronic renal disease and the major cause of end-stage renal failure worldwide, predominantly due to the increase of Type 2 diabetes associated with obesity. The intimate mechanisms leading to the development and progression of renal injury in DKD are not well understood, but current knowledge indicates that its pathogenesis is multifactorial, where the immune response and inflammation appear to be relevant factors. Summary: This review summarizes the role of relevant inflammatory molecules and pathways that participate in the development of DKD. Likewise, we focused on the new therapeutic approaches based on anti-inflammatory effects of different drugs. Key Messages: This new pathogenic perspective of DKD as an inflammatory condition leads to novel horizons, such as the potential role of inflammatory signaling pathways and their downstream products as emerging biomarkers and promising therapeutic targets.
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Citations
Cited by
Diabetic Nephropathy: Challenges in Pathogenesis, Diagnosis, and Treatment
Samsu, N. (2021) · BioMed Research International · doi:10.1155/2021/1497449 · Cited by 1,001
Zhao, L., Zhang, H., Li, N., Chen, J., Xu, H., Wang, Y., & Liang, Q. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116306 · Cited by 963
Molecular mechanisms and therapeutic targets for diabetic kidney disease
Tuttle, K. R., Agarwal, R., Alpers, C. E., Bakris, G. L., Brosius, F. C., Kolkhof, P., & Uribarri, J. (2022) · Kidney International · doi:10.1016/j.kint.2022.05.012 · Cited by 668
ICAM-1 and VCAM-1: Gatekeepers in various inflammatory and cardiovascular disorders
Singh, V., Kaur, R., Kumari, P., Pasricha, C., & Singh, R. (2023) · Clinica Chimica Acta · doi:10.1016/j.cca.2023.117487 · Cited by 432
Unraveling the Role of Inflammation in the Pathogenesis of Diabetic Kidney Disease
Matoba, K., Takeda, Y., Nagai, Y., Kawanami, D., Utsunomiya, K., & Nishimura, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143393 · Cited by 223
Metadata
- Authors
- Pérez-Morales, R. E., del Pino, M. D., Valdivielso, J. M., Ortiz, A., Mora-Fernández, C., & Navarro-González, J. F.
- Venue
- Nephron
- Publisher
- S. Karger AG
- Published
- 2018-10-01
- Volume
- 143
- Issue
- 1
- Pages
- 12-16
- ISSN
- 1660-8151 (ISSN-L)
- 2235-3186
- OpenAlex
- W2893204356
- Cited by
- 304
- References
- 0
- FWCI
- 9.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pérez-Morales, R. E., del Pino, M. D., Valdivielso, J. M., Ortiz, A., Mora-Fernández, C., & Navarro-González, J. F. (2019). Inflammation in Diabetic Kidney Disease. Nephron. https://doi.org/10.1159/000493278
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