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Cited by 28Inflammatory Biomarkers in Disease PrognosisTesticular diseases and treatmentsCancer, Stress, Anesthesia, and Immune Response

The DOI matches its Crossref record.

May High Levels of Systemic Immune-Inflammation Index and Hematologic Inflammation Markers Suggest a Further Stage in Testicular Tumours?

Imamoglu, Goksen Inanc, Eren, Tulay, Baylan, Burhan, Karacın, Cengız·2019·Urologia Internationalis
DOI 10.1159/000502658
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Abstract

Introduction: Due to variety of treatment alternatives for testicular tumours, parameters other than existing staging criteria are also needed. Most studies have revealed the correlation between cancer and inflammation. In this study, we aimed to investigate the value of preoperative inflammatory markers between early-stage testicular tumours and patients with advanced-stage, their relationship with tumour pathology and their importance in predicting stage. To calculate the differences between inflammatory markers, stage 1 tumours localized to the testis and advanced-stage tumours spread beyond the testis were classified into 2 groups according to tumour pathology. Materials and Methods: The data of 112 patients undergoing inguinal orchiectomy in between 2008 and 2018 were recorded retrospectively. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR) and systemic immune-inflammation index (SII) were calculated by using the numbers of blood cell counts based systemic markers of inflammation. The differences between markers of inflammation were calculated by dividing tumours into 2 groups including early-stage and advanced- stage testicle tumours. Results: According to the results of preoperative inflammatory markers in predicting the stage; in the seminoma group, the difference between the median NLR (2.37 vs. 4.39, p = 0.012), LMR (3.80 vs. 2.40, p = 0.018) and SII (612 vs. 1,127, p = 0.009) of stage 1 and advanced stage were statistically significant, while in the non-seminoma group, only the difference between median PLR (99 vs. 154, p = 0.002) of stage 1 and advanced stage was statistically significant. Sensitivity and specificity of predicting advanced stage according to cut-off values of markers were 69 and 75% in NLR (3.21), 83 and 75% in LMR, and 59 and 75% in SII in the seminoma group; on the other hand, in the non-seminoma group, the sensitivity, and specificity of predicting the advanced stage of PLR cut-off (104) were 71 and 88% respectively. Conclusions: The clinical use of inflammatory biomarkers in testicular tumours may represent an important step in understanding germ cell tumours biology and in supporting staging criteria and prognostic criteria.

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Metadata

Authors
Imamoglu, G. I., Eren, T., Baylan, B., & Karacın, C.
Affiliations
Ministry of Health (TR)
ORCID
Venue
Urologia Internationalis
Publisher
S. Karger AG
Published
2019
Volume
103
Issue
3
Pages
303-310
ISSN
  • 0042-1138 (ISSN-L)
  • 1423-0399
DOI
10.1159/000502658
OpenAlex
W2975836509
Cited by
28
References
0
Citations by year
2026: 1 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 4 · 2020: 6
FWCI
1.79
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Urologia Internationalis (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
  • Health Sciences › Medicine › Surgery › Testicular diseases and treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
Keywords
testicular tumours, systemic immune-inflammation index, inflammatory markers, tumor staging, seminoma, non-seminoma, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, preoperative inflammation, tumor inflammation, orchiectomy, prognostic factors
MeSH terms
Adult, Humans, Inflammation, Male, Middle Aged, Neoplasm Staging, Retrospective Studies, Testicular Neoplasms, Biomarkers, Tumor, Young Adult

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