Sleep, Orexin and Cognition
Open accessAbstract
Orexins regulate a wide variety of biological functions, most notably the sleep-wake cycle, reward and stress processing, alertness, vigilance, and cognitive functioning. Alterations of central and peripheral orexin levels are linked to conditions such as narcolepsy, anorexia nervosa, age-related cognitive decline, and neurodegenerative disease. Preliminary studies suggest that orexin mimetics can safely promote the wake signal via orexin agonism during the day and that orexin receptor antagonists can promote the sleep signal during the night. Thus, novel orexin therapies have the potential to either improve memory, cognition, and daytime performance directly or indirectly, through promotion of good sleep. The full scope of the therapeutic potential of orexin therapies remains to be elucidated.
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Orexin is associated with memory processing, motivation, reward, and addiction, which have been described as behaviors that are affected by TBI.
“Orexin is also associated with memory processing,113–116 motivation, reward,117 and addiction,118 which have been described as behaviors that are affected by TBI.9,119–123”
From Effects of Traumatic Brain Injury on the Orexin/Hypocretin System (2025) · cites this paper as [115]
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Zhou, M., Tang, J., Li, S., Li, Y., & Zhao, M. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.1029554 · Cited by 24 · see citing works
Effects of Traumatic Brain Injury on the Orexin/Hypocretin System
Somach, R. T., Lim, M. M., & Cohen, A. S. (2025) · Neurotrauma Reports · doi:10.1089/neur.2024.0111 · Cited by 2 · see citing works
- Authors
- Toor, B., Ray, L. B., Pozzobon, A., & Fogel, S. M.
- Affiliations
- University of Ottawa (CA)
- Venue
- Frontiers of Neurology and Neuroscience
- Publisher
- S. Karger AG
- Published
- 2021
- Volume
- 45
- Pages
- 38-51
- ISSN
- 0300-5186 (ISSN-L)
- 1660-4431
- 1662-2804
- OpenAlex
- W3165630195
- Cited by
- 64
- References
- 0
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 14 · 2023: 19 · 2022: 4
- FWCI
- 32.31
- Type
- book chapter
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Monographs in clinical neuroscience/Frontiers of neurology and neuroscience/Monographs in neural sciences (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- orexin, sleep-wake cycle, cognition, orexin receptor antagonists, narcolepsy, anorexia nervosa, age-related cognitive decline, neurodegenerative diseases, memory, alertness
- MeSH terms
- Orexins, Aging, Alzheimer Disease, Animals, Anorexia Nervosa, Humans, Narcolepsy, Parkinson Disease, Sleep, Cognitive Dysfunction, Orexin Receptors
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