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Cited by 54Lipid metabolism and biosynthesisAlzheimer's disease research and treatmentsFatty Acid Research and Health

Brain Lipids and Lipid Droplet Dysregulation in Alzheimer’s Disease and Neuropsychiatric Disorders

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Zhao, Xiaojie, Zhang, Siwei, Sanders, Alan R., Duan, Jubao·2023·Complex Psychiatry
DOI 10.1159/000535131PMC PMC10697751
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Abstract

Background: Lipids are essential components of the structure and for the function of brain cells. The intricate balance of lipids, including phospholipids, glycolipids, cholesterol, cholesterol ester, and triglycerides, is crucial for maintaining normal brain function. The roles of lipids and lipid droplets and their relevance to neurodegenerative and neuropsychiatric disorders (NPDs) remain largely unknown. Summary: Here, we reviewed the basic role of lipid components as well as a specific lipid organelle, lipid droplets, in brain function, highlighting the potential impact of altered lipid metabolism in the pathogenesis of Alzheimer’s disease (AD) and NDPs. Key Messages: Brain lipid dysregulation plays a pivotal role in the pathogenesis and progression of neurodegenerative and NPDs including AD and schizophrenia. Understanding the cell type-specific mechanisms of lipid dysregulation in these diseases is crucial for identifying better diagnostic biomarkers and for developing therapeutic strategies aiming at restoring lipid homeostasis.

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  • Lipid droplets (LDs) have important roles in ageing and Alzheimer's disease (AD).

    “Moreover, LDs—cellular organelles containing lipids such as glycerolipids and cholesterol—were recently found to have important roles in ageing and Alzheimer's disease (AD)10–15.”

    From PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia (2025) · cites this paper as [15]

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Authors
Zhao, X., Zhang, S., Sanders, A. R., & Duan, J.
Affiliations
Endeavor Health (US)
Corresponding author
Duan, Jubao
ORCID
Venue
Complex Psychiatry
Publisher
S. Karger AG
Published
2023
Volume
9
Issue
1-4
Pages
154-171
ISSN
  • 2673-298X (ISSN-L)
  • 2673-3005
DOI
10.1159/000535131
PMC
PMC10697751
OpenAlex
W4388517796
Cited by
54
References
226
Citations by year
2026: 19 · 2025: 22 · 2024: 13
FWCI
5.43
Type
journal article
Language
en
Open access
Licence
Locations
  • Complex Psychiatry (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute on Aging (R01AG063175, R01AG081374)
  • National Institute of Mental Health (R01MH116281, R01MH106575)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords
brain lipids, lipid droplets, Alzheimer's disease, neuropsychiatric disorders, lipid metabolism, neurodegenerative diseases, schizophrenia, lipid homeostasis, phospholipids, cholesterol, triglycerides, diagnostic biomarkers

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