Neutrophil function in the healing wound: adding insult to injury?
Abstract
Summary: Cells of the innate immune system, including neutrophils and macrophages, are a highly visible component of normal wound healing in adult mammals. The role of inflammatory cells in the healing wound has been widely investigated, and evidence for both positive and negative influences exists. Several recent investigations support the emerging paradigm that robust inflammation is detrimental to wound closure. This developing information suggests that the functional role of inflammatory cells in wound healing must be reevaluated.
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Neutrophils produce free oxygen radicals resulting in oxidative stress, which damages tissue and delays healing.
“For example, neutrophil proteases can degrade ECM as well as the proteins important for repair, e.g., clotting factors, complement, cytokines and immunoglobulin [66, 67]; they produce free oxygen radicals resulting in oxidative stress, which further damage tissue and delay healing [67].”
From Transition from inflammation to proliferation: a critical step during wound healing (2016) · cites this paper as [67]
Neutrophil proteases can degrade ECM and proteins important for repair.
“For example, neutrophil proteases can degrade ECM as well as the proteins important for repair, e.g., clotting factors, complement, cytokines and immunoglobulin [66, 67]; they produce free oxygen radicals resulting in oxidative stress, which further damage tissue and delay healing [67].”
From Transition from inflammation to proliferation: a critical step during wound healing (2016) · cites this paper as [67]
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References 48 · Cited by 217
- Authors
- Dovi, J., Szpaderska, A., & DiPietro, L.
- Affiliations
- Loyola University Medical Center (US)
- Corresponding author
- DiPietro, Luisa
- ORCID
- DiPietro, Luisa
- Venue
- Thrombosis and Haemostasis
- Publisher
- Georg Thieme Verlag KG
- Published
- 2004
- Volume
- 92
- Issue
- 08
- Pages
- 275-280
- ISSN
- 0340-6245 (ISSN-L)
- 2567-689X
- OpenAlex
- W2029759983
- Cited by
- 217
- References
- 48
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 13 · 2023: 8 · 2022: 9 · 2021: 11 · 2020: 12 · 2019: 7 · 2018: 13 · 2017: 13 · 2016: 12 · 2015: 11 · 2014: 15 · 2013: 18 · 2012: 18
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Thrombosis and Haemostasis (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NIH (GM55238)
- Falk Medical Research Trust
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- neutrophils, wound healing, inflammation, macrophages, innate immunity, inflammatory cells, wound closure
- MeSH terms
- Animals, Epithelial Cells, Humans, Immune System, Inflammation, Macrophages, Neutrophils, Wound Healing, Cell Proliferation
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