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Cited by 125Venous Thromboembolism Diagnosis and ManagementDiagnosis and Treatment of Venous DiseasesVascular anomalies and interventions

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The post-thrombotic syndrome: incidence and prognostic value of non-invasive venous examinations in a six-year follow-up study

Heijer, Martin den, Janssen, Mirian C. H., Vleuten, Carine van der, Thien, Theo, Wollersheim, Hub, Roumen-Klappe, Edith M.·2005·Thrombosis and Haemostasis
DOI 10.1160/th05-03-0146
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Abstract

The ability to predict severity of the post-thrombotic syndrome (PTS) early after acute deep-vein thrombosis (DVT) is limited. The aim of our study was to examine the incidence of PTS prospectively and to evaluate the predictive value of non-invasive venous examinations shortly after DVT for the development of PTS. In 93 patients with DVT thrombosis score (TS), reflux, venous outflow resistance (VOR) and calf muscle pump dysfunction (CMP) were examined prospectively. After one, two and six years patients were evaluated for PTS using the clinical scale of the CEAP-classification (PTS present > or = 3 on a scale from 0 to 6). Area under the curves (AUC) were used to evaluate the predictive value of the non-invasive examinations at one and three months after diagnosis of DVT for future PTS. The cumulative incidence of PTS increased from 49% (32/65) after one year to 55% (36/65) and 56% (27/48) after two and six years, whereas the incidence of patients with PTS class 4 progressed from 20% after two years to 33% after six years. The prognostic value to predict PTS was highest for the combination of TS, VOR and reflux measured three months after diagnosis and showed an AUC of 0.77 (0.65-0.90) for PTS after one year. In conclusion, the incidence of PTS after DVT did not increase significantly after one year, whereas during longer follow-up the severity of PTS rose in patients with PTS. Moreover, measurement of TS, VOR and reflux three months after DVT could predict, with reasonable…

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Research works printed but not linked: 26

  1. MC Janssen, 1996, The post-thrombotic syndrome, a review, Phlebology, 11, 86, 10.1177/026835559601100302 · DOI
  2. SR Kahn, 2000, Longterm outcomes after deep vein thrombosis: postphlebitic syndrome and quality of life, J Gen Intern Med, 15, 425, 10.1046/j.1525-1497.2000.06419.x · DOI
  3. M Nordstrom, 1992, A prospective study of the incidence of deep-vein thrombosis within a defined urban population, J Intern Med, 232, 155, 10.1111/j.1365-2796.1992.tb00565.x · DOI
  4. R Van den Oever, 1998, Socioeconomic impact of chronic venous insufficiency. An underestimated public health problem, Int Angiol, 17, 161
  5. D Bergqvist, 1997, Cost of long-term complications of deep venous thrombosis of the lower extremities: an analysis of a defined patient population in Sweden, Ann Intern Med, 126, 454, 10.7326/0003-4819-126-6-199703150-00006 · DOI
  6. DP Brandjes, 1997, Randomised trial of effect of compression stockings in patients with symptomatic proximal-vein thrombosis, Lancet, 349, 759, 10.1016/S0140-6736(96)12215-7 · DOI
  7. MH Meissner, 1998, Determinants of chronic venous disease after acute deep venous thrombosis, J Vasc Surg, 28, 826, 10.1016/S0741-5214(98)70057-6 · DOI
  8. BJF Klein Rouweler, 1990, Plethysmographic measurement of venous flow resistance and venous capacity in humans with deep venous thrombosis, Phlebology, 5, 21, 10.1177/026835559000500106 · DOI
  9. MC Janssen, 1997, Clinical and haemodynamic sequelae of deep venous thrombosis: retrospective evaluation after 7–13 years, Clin Sci, 93, 7, 10.1042/cs0930007 · DOI
  10. JI Arcelus, 1996, Laboratory assays and duplex scanning outcomes after symptomatic deep vein thrombosis: preliminary results, J Vasc Surg, 23, 616, 10.1016/S0741-5214(96)80041-3 · DOI
  11. LA Killewich, 1997, Regression of proximal deep venous thrombosis is associated with fibrinolytic enhancement, J Vasc Surg, 26, 861, 10.1016/S0741-5214(97)70101-0 · DOI
  12. JM Porter, 1995, Reporting standards in venous disease: an update. International Consensus Committee on Chronic Venous Disease, J Vasc Surg, 21, 635, 10.1016/S0741-5214(95)70195-8 · DOI
  13. BJF Klein Rouweler, 1989, Plethysmographic measurement of venous flow resistance and venous capacity in the human leg. Part One: method, Phlebology, 4, 241, 10.1177/026835558900400405 · DOI
  14. BJF Klein Rouweler, 1989, Plethysmographic measurement of venous flow resistance and venous capacity in human legs. Part two: Normal values related to age, sex and site of measurement, Phlebology, 4, 251, 10.1177/026835558900400406 · DOI
  15. MC Janssen, 1996, Validation of the supine venous pump function test: a new non-invasive tool in the assessment of deep venous insufficiency, Clin Sci, 91, 483, 10.1042/cs0910483 · DOI
  16. JH Haenen, 1999, Venous duplex scanning of the leg: range, variability and reproducibility, Clin Sci, 96, 271, 10.1042/cs0960271 · DOI
  17. P Prandoni, 2004, Belowknee elastic compression stockings to prevent the postthrombotic syndrome: a randomized, controlled trial, Ann Intern Med, 141, 249, 10.7326/0003-4819-141-4-200408170-00004 · DOI
  18. P Prandoni, 1997, The clinical course of deep-vein thrombosis. Prospective long-term follow-up of 528 symptomatic patients, Haematologica, 82, 423
  19. UK Franzeck, 1996, Prospective 12-year follow-up study of clinical and hemodynamic sequelae after deep vein thrombosis in low-risk patients (Zurich study), Circulation, 93, 74, 10.1161/01.CIR.93.1.74 · DOI
  20. AN Nicolaides, 2000, Investigation of chronic venous insufficiency: A consensus statement, Circulation, 102, E126, 10.1161/01.CIR.102.20.e126 · DOI · Paper page
  21. C Lagerstedt, 1993, Recurrence and late sequelae after first-time deep vein thrombosis: relationship to initial signs, Phlebology, 8, 62, 10.1177/026835559300800205 · DOI
  22. M Monreal, 1993, Venographic assessment of deep vein thrombosis and risk of developing post-thrombotic syndrome: a prospective study, J Intern Med, 233, 233, 10.1111/j.1365-2796.1993.tb00981.x · DOI
  23. P Prandoni, 2005, Vein abnormalities and the post-thrombotic syndrome, J Thromb Haemost, 3, 401, 10.1111/j.1538-7836.2004.01106.x · DOI
  24. CT Araki, 1994, The significance of calf muscle pump function in venous ulceration, J Vasc Surg, 20, 872, 10.1016/0741-5214(94)90223-2 · DOI
  25. BF Johnson, 1996, The site of residual abnormalities in the leg veins in long-term follow-up after deep vein thrombosis and their relationship to the development of the post-thrombotic syndrome, Int Angiol, 15, 14
  26. JA Caprini, 1999, Deep vein thrombosis outcome and the level of oral anticoagulation therapy, J Vasc Surg, 30, 805, 10.1016/S0741-5214(99)70004-2 · DOI

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Metadata

Authors
Heijer, M. D., Janssen, M. C. H., Vleuten, C. V. D., Thien, T., Wollersheim, H., & Roumen-Klappe, E. M.
ORCID
Janssen, Mirian C. H.
Venue
Thrombosis and Haemostasis
Publisher
Georg Thieme Verlag KG
Published
2005
Volume
94
Issue
10
Pages
825-830
ISSN
  • 0340-6245 (ISSN-L)
  • 2567-689X
DOI
10.1160/th05-03-0146
OpenAlex
W2051396185
Cited by
125
References
0
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 7 · 2019: 8 · 2018: 10 · 2017: 12 · 2016: 8 · 2015: 6 · 2014: 10 · 2013: 10 · 2012: 8
FWCI
2.25
Type
journal article
Language
en
Open access
closed
Locations
  • Thrombosis and Haemostasis (publishedVersion)
  • PubMed (publishedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
  • Pure Amsterdam UMC (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
  • Health Sciences › Medicine › Surgery › Diagnosis and Treatment of Venous Diseases
  • Health Sciences › Medicine › Surgery › Vascular anomalies and interventions
Keywords
post-thrombotic syndrome, deep vein thrombosis, incidence, prognostic value, venous outflow resistance, venous reflux, CEAP classification, long-term follow-up
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Diagnostic Techniques, Cardiovascular, Female, Follow-Up Studies, Humans, Male, Middle Aged, Postphlebitic Syndrome, Predictive Value of Tests, Prognosis, Risk Factors, Saphenous Vein, Severity of Illness Index, Vascular Resistance, Incidence, Muscle, Skeletal, Venous Thrombosis

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