The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
HDL Apolipoproteins and ABCA1: Partners in the Removal of Excess Cellular Cholesterol
Open accessAbstract
It is widely believed that HDL protects against atherosclerosis by removing excess cholesterol from arterial cells. Lipid-poor HDL apolipoproteins promote efflux of cholesterol, phospholipids, and other lipophilic molecules from cells by an active process mediated by a cell-membrane transporter called the ATP binding cassette transporter A-1 (ABCA1). ABCA1 either directly or indirectly translocates phospholipids and cholesterol to the cell surface, where they appear to form lipid domains that interact with amphipathic α-helixes in apolipoproteins. This interaction solubilizes these lipids and generates nascent HDL particles that dissociate from the cell. Binding of apolipoproteins to ABCA1 may also enhance the activity of this lipid-transport pathway. Thus, the apolipoprotein/ABCA1 pathway efficiently clears cells of excess cholesterol that would otherwise accumulate as intracellular lipid droplets. ABCA1 expression is highly induced by cholesterol loading of cells and is also modulated by sterol-independent mechanisms at both the transcriptional and posttranslational level. Studies of human disease and animal models have shown that both an increased availability of apolipoproteins and an enhanced macrophage ABCA1 activity are atheroprotective. These findings implicate the apolipoprotein/ABCA1 pathway as an important therapeutic target for treating cardiovascular disease.
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Cites
Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
Brooks-Wilson, A., Marcil, M., Clee, S. M., Zhang, L.-H., Roomp, K., van Dam, M., Yu, L., Brewer, C., Collins, J. A., Molhuizen, H. O. F., et al. (1999) · Nature Genetics · doi:10.1038/11905 · Cited by 1,687
Chinetti, G., Lestavel, S., Bocher, V., Remaley, A. T., Neve, B., Torra, I. P., Teissier, E., Minnich, A., Jaye, M., Duverger, N., et al. (2001) · Nature Medicine · doi:10.1038/83348 · Cited by 1,170
Bungert, S., Molday, L. L., & Molday, R. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101902200 · Cited by 173
Liver X Receptor (LXR) Regulation of the LXRα Gene in Human Macrophages
Whitney, K. D., Watson, M. A., Goodwin, B., Galardi, C. M., Maglich, J. M., Wilson, J. G., Willson, T. M., Collins, J. L., & Kliewer, S. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106155200 · Cited by 154
Cited by
Oram, J. F., & Heinecke, J. W. (2005) · Physiological Reviews · doi:10.1152/physrev.00005.2005 · Cited by 521
Self-citationImportance of Different Pathways of Cellular Cholesterol Efflux
Yancey, P. G., Bortnick, A. E., Kellner-Weibel, G., de la Llera-Moya, M., Phillips, M. C., & Rothblat, G. H. (2003) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000057572.97137.dd · Cited by 507
Bergt, C., Pennathur, S., Fu, X., Byun, J., O'Brien, K., McDonald, T. O., Singh, P., Anantharamaiah, G. M., Chait, A., Brunzell, J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405292101 · Cited by 454
Self-citationAviram, M., & Rosenblat, M. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.06.030 · Cited by 434
Vedhachalam, C., Duong, P. T., Nickel, M., Nguyen, D., Dhanasekaran, P., Saito, H., Rothblat, G. H., Lund-Katz, S., & Phillips, M. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704590200 · Cited by 337
Metadata
- Authors
- Oram, J. F.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2003-05
- Volume
- 23
- Issue
- 5
- Pages
- 720-727
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2129077731
- Cited by
- 253
- References
- 4
- FWCI
- 24.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Oram, J. F. (2003). HDL Apolipoproteins and ABCA1: Partners in the Removal of Excess Cellular Cholesterol. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/01.atv.0000054662.44688.9a
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
