Weight Reduction With Very-Low-Caloric Diet and Endothelial Function in Overweight Adults: Role of Plasma Glucose
Abstract
Objective— Obesity is associated with endothelial dysfunction that may contribute to the development of atherosclerosis. We studied whether weight reduction improves endothelial function in overweight individuals. Methods and Results— Flow-mediated endothelium-dependent vasodilation of the brachial artery was measured in 67 adults (age: 46±7 years, body mass index: 35.2±5.4 kg/m 2 ) before and after a 6-week weight reduction program induced by very-low-calorie diet (daily energy: 580 kcal/2.3 MJ). Caloric restriction reduced body weight from 101±18 to 90±17 kg. Flow-mediated vasodilation increased from 5.5%±3.7 to 8.8%±3.7% ( P <0.0001). Nitrate-mediated vasodilation was not significantly affected. The improvement in flow-mediated dilation was associated with the reduction in plasma glucose concentration ( P =0.0003). This relationship was independent of changes in weight, serum lipids, oxidized LDL, C-reactive protein, adiponectin, blood pressure, and insulin. Conclusions— Weight reduction with very-low-calorie diet improves flow-mediated vasodilation in obese individuals. This improvement is related to the reduction in plasma glucose concentration. These observations suggest that changes in glucose metabolism may determine endothelial vasodilatory function in obesity.
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Obesity and prediabetes cause endothelial dysfunction, which is reversible with weight loss if severe vascular injury has not occurred.
“Obesity and prediabetes also cause endothelial dysfunction, which is reversible with weight loss if severe vascular injury has not occurred38,39.”
From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [38]
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References 52 · Cited by 198
- Authors
- Raitakari, M., Ilvonen, T., Ahotupa, M., Lehtimäki, T., Harmoinen, A., Suominen, P., Elo, J., Hartiala, J., & Raitakari, O. T.
- Affiliations
- University of Turku (FI)
- From the Departments of Clinical Physiology (J.H., O.T.R.), Clinical Chemistry (M.R., P.S.), PET-Centre (O.T.R.), Physiology (M.A.) (MCA Research Laboratory), University of Turku, Finland; Medical Centre Mehiläinen (T.I., P.S., J.H. O.T.R.), Turku, Finland; Leiras Finland, Inc. (J.E.), Turku, Finland; and Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Centre for Laboratory Medicine (T.L., A.H.), Tampere University Hospital and University of Tampere, Finland.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2004-01
- Volume
- 24
- Issue
- 1
- Pages
- 124-128
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W1971066944
- Cited by
- 198
- References
- 52
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 5 · 2018: 8 · 2017: 4 · 2016: 9 · 2015: 12 · 2014: 9 · 2013: 11 · 2012: 10
- FWCI
- 8.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Academy of Finland (201888)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- very low calorie diet, weight loss, endothelial function, endothelial dysfunction, flow-mediated dilation, plasma glucose, obesity, overweight adults, caloric restriction, glucose metabolism
- MeSH terms
- Blood Glucose, C-Reactive Protein, Diet, Reducing, Endothelium, Vascular, Fasting, Female, Food, Formulated, Humans, Insulin, Lipids, Male, Obesity, Proteins, Smoking, Vasodilation, Weight Loss, Treatment Outcome, Postmenopause, Hemorheology, Hormone Replacement Therapy, Intercellular Signaling Peptides and Proteins, Adiponectin
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