Stored Iron and Vascular Reactivity
Abstract
heng et al 1 report that volunteer blood donors with a high donation frequency have significantly greater flow-mediated dilation than low frequency donors.Iron status among the frequent donors approximated a state of iron depletion by assessment of conventional iron markers.The study provides important support for the "iron hypothesis," which suggests a protective effect of iron depletion, ie, the absence of storage iron without anemia, against ischemic heart disease.[2][3][4] The blood donor findings suggest a new direction for the study of endothelial iron status in vivo to complement a growing body of work on iron in cultured endothelial cells.In addition, the finding of lower serum nitrotyrosine in frequent donors is consistent with the hypothesis that myeloperoxidase, a powerful emerging cardiovascular risk factor, 5-8 is modifiable by manipulation of iron status.
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Elevated iron stores can predispose to coronary artery disease and thence myocardial infarction.
“It is well known that elevated iron stores can predispose to coronary artery disease and thence myocardial infarction.”
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References 64 · Cited by 41
- Authors
- Sullivan, J. L.
- Affiliations
- University of Florida Health (US)
- Corresponding author
- Sullivan, Jerome L.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2005-08
- Volume
- 25
- Issue
- 8
- Pages
- 1532-1535
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2144174958
- Cited by
- 41
- References
- 64
- Citations by year
- 2025: 1 · 2021: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 2
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- stored iron, iron depletion, iron hypothesis, flow-mediated dilation, vascular reactivity, endothelial function, blood donors, donation frequency, myeloperoxidase, ischemic heart disease, cardiovascular risk factors
- MeSH terms
- Animals, Endothelium, Vascular, Humans, Iron, Risk Factors, Vasodilation, Myocardial Ischemia
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