Iron Chelation and Vascular Function: In Search of the Mechanisms
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I n 1981, Sullivan suggested that a state of iron depletion (ie, reduced iron stores without anemia) was potentially protective against coronary heart disease (CHD). 1 This original "iron hypothesis" was an attempt to explain the known sex difference in cardiovascular (CV) risk and the subsequent loss of the protective effect of female gender with menopause.This initial hypothesis was based in part on the observation that men exhibited an age-dependent increase in the accumulation of iron that was not seen in women until after menopause.This, coupled with the observation that hysterectomy without oophorectomy was associated with an increased CHD risk, supported the concept that a diminution in iron stores was protective against CHD.Basic and clinical data have recently begun to provide plausible explanations for a link between iron and atherosclerosis.2,
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Iron chelation by deferoxamine reduced expression of oxidative stress markers and delayed formation of atherosclerotic lesions in high-cholesterol diet-fed rabbits.
“Iron chelation by deferoxamine reduced the expression of oxidative stress markers and delayed the formation of atherosclerotic lesions, indicating that chelation therapy may aid in prevention of atherosclerosis [63, 76].”
From The utility of iron chelators in the management of inflammatory disorders (2015) · cites this paper as [76]
Iron depletion by dietary or other means delays atherosclerosis.
“iron depletion by dietary or other means delays this [778-782].”
Iron depletion by dietary or other means delays the formation of atherosclerotic lesions.
“Iron depletion by dietary or other means delays the formation of such lesions”
From Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples (2010) · cites this paper as Ferrara and Taylor 2005
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References 21 · Cited by 21
Research works printed but not linked: 14
- Grinshtein N, Bamm VV, Tsemakhovich VA, Shaklai N. Mechanism of low-density lipoprotein oxidation by hemoglobin-derived iron. Bio- chemistry. 2003;42:6977-6985.
- Camejo G, Halberg C, Manschik-Lundin A, Hurt-Camejo E, Rosengren B, Olsson H, Hansson GI, Forsberg GB, Ylhen B. Hemin binding and oxidation of lipoproteins in serum: mechanisms and effect on the interaction of LDL with human macrophages. J Lipid Res Apr. 1998;39:755-766.
- Juckett MB, Balla J, Balla G, Jessurun J, Jacob HS, Vercellotti GM. Ferritin protects endothelial cells from oxidized low density lipoprotein in vitro. Am J Pathol Sep. 1995;147:782-789.
- Kikinis Z, Eisenstein RS, Bettany AJ, Munro HN. Role of RNA sec- ondary structure of the iron-responsive element in translational regulation of ferritin synthesis. Nucleic Acids Res. 1995;23:4190 -4195.
- Vile GF, Tyrrell RM. Oxidative stress resulting from ultraviolet A irra- diation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin. J Biol Chem. 1993;268:14678 -14681.
- Ishizaka N, de Leon H, Laursen JB, Fukui T, Wilcox JN, De Keulenaer G, Griendling KK, Alexander RW. Angiotensin II-induced hypertension Known and potential mechanisms for the involvement of iron and iron chelators in modulating angiotensin II-mediated oxi- dative events. increases heme oxygenase-1 expression in rat aorta. Circulation. 1997; 96:1923-1929.
- Zheng H, Cable R, Spencer B, Votto N, Katz SD. Iron stores and vascular function in voluntary blood donors. Arterioscler Thromb Vasc Biol. 2005;25:1577-1583.
- Gaenzer H, Marschang P, Sturm W, Neumayr G, Vogel W, Patsch J, Weiss G. Association between increased iron stores and impaired endo- thelial function in patients with hereditary hemochromatosis. J Am Coll Cardiol. 2002;40:2189 -2194.
- Cooper CE. Nitric oxide and iron proteins. Biochim Biophys Acta. 1999; 1411:290 -309.
- Ishizaka N, Saito K, Mori I, Nagai R. Iron chelation supresses the ferritin upregulation and attenuates vascular dysfunction in the aorta of angio- tensin II-infused rats. Arterioscler Thromb Vasc Biol. 2005;25: 2282-2288.
- Yavin E, Kikkiri R, Gil S, Arad-Yellin R, Shanzer A. Synthesis and biological evaluation of lipophilic iron chelators as protective agents from oxidative stress. Org Biomol Chem. 2005;3:2685-2687.
- Bartesaghi S, Trujillo M, Denicola A, Folkes L, Wardman P, Radi R. Reactions of desferrioxamine with peroxynitrite-derived carbonate and nitrogen dioxide radicals. Free Radic Biol Med. 2004;36:471-483.
- Biemond P, Swaak AJ, Beindorff CM, Koster JF. Superoxide-dependent and -independent mechanisms of iron mobilization from ferritin by xanthine oxidase. Implications for oxygen-free-radical-induced tissue destruction during ischaemia and inflammation. Biochem J. 1986;239: 169 -173.
- Zacharski LR, Chow B, Lavori PW, Howes PS, Bell MR, DiTommaso MA, Carnegie NM, Bech F, Amidi M, Muluk S. The iron (Fe) and atherosclerosis study (FeAST): a pilot study of reduction of body iron stores in atherosclerotic peripheral vascular disease. Am Heart J Feb. 2000;139:337-345.
- Authors
- Ferrara, D. E., & Taylor, W. R.
- Affiliations
- Emory University (US)
- ORCID
- Taylor, W. Robert
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2005-11
- Volume
- 25
- Issue
- 11
- Pages
- 2235-2237
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2161960958
- Cited by
- 21
- References
- 21
- Citations by year
- 2021: 1 · 2017: 1 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 2
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
- Keywords
- iron chelation, iron depletion, iron stores, vascular function, coronary artery disease, sex differences in cardiovascular risk, menopause, hysterectomy, atherosclerosis, iron accumulation
- MeSH terms
- Animals, Humans, Iron, Iron Chelating Agents, Oxidative Stress, Atherosclerosis
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