The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
Pathogenesis of Calcific Aortic Valve Disease: A Disease Process Comes of Age (and a Good Deal More)
Open accessAbstract
Background— Over the past 10 to 15 years, calcific aortic valve disease, which includes aortic sclerosis and aortic stenosis, has come to be recognized as an active process, based on: (1) epidemiologic studies demonstrating associations of specific risk factors with increased prevalence or rate of progression of aortic valve disease; (2) identification, in valve lesions, of histopathologic features of chronic inflammation, lipoprotein deposition, renin-angiotensin system components, and molecular mediators of calcification; and (3) identification of cell-signaling pathways and genetic factors that may participate in valve disease pathogenesis. These studies will be reviewed and organized into a proposed global hypothesis for the pathogenesis of calcific aortic valve disease.
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Cites
Galis, Z. S., Sukhova, G. K., Lark, M. W., & Libby, P. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117619 · Cited by 2,539
Clinical Factors Associated With Calcific Aortic Valve Disease
Stewart, B. F., Siscovick, D., Lind, B. K., Gardin, J. M., Gottdiener, J. S., Smith, V. E., Kitzman, D. W., & Otto, C. M. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(96)00563-3 · Cited by 2,029 · cited 4×
“After oxidative modification, oxidized LDL (OxLDL): (1) induces endothelial cell expression of adhesion molecules (VCAM-1, ICAM-1) and chemoattractants (MCP-1), leading to monocyte-macrophage infiltration, and (2) is taken up by macrophages, leading to macrophage foam cell formation and activation.”
InfluentialMutations in NOTCH1 cause aortic valve disease
Garg, V., Muth, A. N., Ransom, J. F., Schluterman, M. K., Barnes, R., King, I. N., Grossfeld, P. D., & Srivastava, D. (2005) · Nature · doi:10.1038/nature03940 · Cited by 1,509
Predictors of Outcome in Severe, Asymptomatic Aortic Stenosis
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Self-citationAssociation of Aortic-Valve Sclerosis with Cardiovascular Mortality and Morbidity in the Elderly
Otto, C. M., Lind, B. K., Kitzman, D. W., Gersh, B. J., & Siscovick, D. S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907153410302 · Cited by 1,283
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Otto, C. M., Burwash, I. G., Legget, M. E., Munt, B. I., Fujioka, M., Healy, N. L., Kraft, C. D., Miyake-Hull, C. Y., & Schwaegler, R. G. (1997) · Circulation · doi:10.1161/01.cir.95.9.2262 · Cited by 1,146
A Randomized Trial of Intensive Lipid-Lowering Therapy in Calcific Aortic Stenosis
Cowell, S. J., Newby, D. E., Prescott, R. J., Bloomfield, P., Reid, J., Northridge, D. B., & Boon, N. A. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043876 · Cited by 1,146
Bone Formation and Inflammation in Cardiac Valves
Mohler, E. R., Gannon, F., Reynolds, C., Zimmerman, R., Keane, M. G., & Kaplan, F. S. (2001) · Circulation · doi:10.1161/01.cir.103.11.1522 · Cited by 1,049
Cited by
Dumesnil, J. G., Pibarot, P., & Carabello, B. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehp361 · Cited by 329
Calcification by Valve Interstitial Cells Is Regulated by the Stiffness of the Extracellular Matrix
Yip, C. Y. Y., Chen, J.-H., Zhao, R., & Simmons, C. A. (2009) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.182394 · Cited by 329
Mohty, D., Pibarot, P., Després, J.-P., Côté, C., Arsenault, B., Cartier, A., Cosnay, P., Couture, C., & Mathieu, P. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.154989 · Cited by 181
Bossé, Y., Miqdad, A., Fournier, D., Pépin, A., Pibarot, P., & Mathieu, P. (2009) · Circulation: Cardiovascular Genetics · doi:10.1161/circgenetics.108.820795 · Cited by 148
Wnt signaling in heart valve development and osteogenic gene induction
Alfieri, C. M., Cheek, J., Chakraborty, S., & Yutzey, K. E. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2009.11.030 · Cited by 138
Metadata
- Authors
- O’Brien, K. D.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2006-08
- Volume
- 26
- Issue
- 8
- Pages
- 1721-1728
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2140233920
- Cited by
- 295
- References
- 77
- FWCI
- 13.78
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Pathogenesis of Calcific Aortic Valve Disease: A Disease Process Comes of Age (and a Good Deal More). https://app.cochat.ai/papers/10.1161/01.atv.0000227513.13697.ac
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- O’Brien, K. D. (2006). Pathogenesis of Calcific Aortic Valve Disease: A Disease Process Comes of Age (and a Good Deal More). Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/01.atv.0000227513.13697.ac
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
