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Fibrinogen Is a Predictor of Mortality in Coronary Heart Disease Patients
Open accessAbstract
Abstract Results of epidemiological studies have indicated that fibrinogen is an important primary cardiovascular risk factor. The role of fibrinogen as a predictor of mortality in coronary heart disease (CHD) patients is unclear. We investigated the association between fibrinogen and mortality in a large cohort of CHD patients screened for participation in a secondary prevention clinical trial. Of the total investigated, 3092 men who were not included in the trial and for whom vital status was known were followed up for a mean period of 3.2 years. In 54.4% of the 111 men who died, mortality was attributed to CHD. Mean baseline plasma fibrinogen levels were 29.4 mg/dL higher in patients who died than in the survivors. All-cause and CHD mortality rates increased with increasing fibrinogen levels. This relationship was also demonstrated within categories of the primary variables predicting mortality in these patients. The contribution of fibrinogen to CHD and all-cause mortality was assessed by multivariate analysis adjusting for age, CHD severity, and comorbidity. Risks of CHD and all-cause mortality for patients in the highest fibrinogen tertile were 1.67 and 1.75, respectively, relative to patients in the lowest tertile, and an increase of about 1 SD of plasma fibrinogen level (75 mg/dL) was found to increase risk of CHD and all-cause mortality by 29% and 31%, respectively. These results indicate clearly that fibrinogen level is associated with significantly increased mortality in CHD patients. Implementation of a standardized measuring method is required to allow assessment of risk in CHD patients on the basis of fibrinogen levels.
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“In the BIP Study, a large-scale clinical study on bezafibrate, fibrinogen was shown to be a predictor of mortality [113]”
From Pemafibrate, a new selective PPARα modulator: drug concept and its clinical applications for dyslipidemia and metabolic diseases (2020) · cites this paper as [113]
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“Fibrinogen is an excellent predictor of mortality especially in patients with cardiovascular complications [11, 12].”
From GHK and DNA: Resetting the human genome to health (2014) · cites this paper as [12]
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Fibrinogen as a Risk Factor for Stroke and Myocardial Infarction
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Plasma Fibrinogen Level and the Risk of Major Cardiovascular Diseases and Nonvascular Mortality
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Metadata
- Authors
- Benderly, M., Graff, E., Reicher-Reiss, H., Behar, S., Brunner, D., & Goldbourt, U.
- Affiliations
- Sheba Medical Center (IL)
- ORCID
- Benderly, Michal
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 1996-03
- Volume
- 16
- Issue
- 3
- Pages
- 351-356
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2143889573
- Cited by
- 118
- References
- 18
- Citations by year
- 2023: 1 · 2021: 2 · 2020: 3 · 2019: 4 · 2016: 2 · 2015: 2 · 2014: 5 · 2013: 1 · 2012: 4
- FWCI
- 12.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Blood properties and coagulation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- fibrinogen, coronary artery disease, mortality prediction, cardiovascular risk factors, all-cause mortality, secondary prevention, plasma fibrinogen levels, risk stratification
- MeSH terms
- Aged, Coronary Disease, Fibrinogen, Follow-Up Studies, Humans, Male, Middle Aged, Smoking
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