The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Homocysteine as a Risk Factor for Vascular Disease: Enhanced Collagen Production and Accumulation by Smooth Muscle Cells
Open accessAbstract
Abstract An increased plasma homocysteine level is an independent risk factor for vascular disease. However, the pathological mechanisms by which homocysteine promotes atherosclerosis are not yet clearly defined. Arterial smooth muscle cells cultured in the presence of homocysteine grew to a higher density and produced and accumulated collagen at levels significantly above control values. Homocysteine concentrations as low as 50 μmol/L significantly increased both cell density and collagen production. Cell density increased by as much as 43% in homocysteine-treated cultures. Homocysteine increased collagen production in a dose-dependent manner. Smooth muscle cells treated with homocysteine at concentrations observed in patients with hyperhomocysteinemia had collagen synthesis rates as high as 214% of control values. Likewise, collagen accumulation in the cell layer was nearly doubled in homocysteine-treated cultures. Addition of aquacobalamin to homocysteine-treated cultures controlled the increase in smooth muscle cell proliferation and collagen production. These results indicate a cellular mechanism for the atherogenicity of homocysteine and provide insight into a potential preventive treatment.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Frosst, P., Blom, H. J., Milos, R., Goyette, P., Sheppard, C. A., Matthews, R. G., Boers, G. J. H., den Heijer, M., Kluijtmans, L. A. J., van den Heuve, L. P., et al. (1995) · Nature Genetics · doi:10.1038/ng0595-111 · Cited by 5,653
A simple, rapid, and sensitive DNA assay procedure
Labarca, C., & Paigen, K. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90165-7 · Cited by 4,901
Boushey, C. J. (1995) · JAMA · doi:10.1001/jama.1995.03530130055028 · Cited by 3,584
Hyperhomocysteinemia: An Independent Risk Factor for Vascular Disease
Clarke, R., Daly, L., Robinson, K., Naughten, E., Cahalane, S., Fowler, B., & Graham, I. (1991) · New England Journal of Medicine · doi:10.1056/nejm199104253241701 · Cited by 2,161
Vitamin Status and Intake as Primary Determinants of Homocysteinemia in an Elderly Population
Selhub, J. (1993) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1993.03510220049033 · Cited by 1,972
A Prospective Study of Plasma Homocyst(e)ine and Risk of Myocardial Infarction in US Physicians
Stampfer, M. J. (1992) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1992.03490070059042 · Cited by 1,709
Two Improved and Simplified Methods for the Spectrophotometric Determination of Hydroxyproline.
Bergman, I., & Loxley, R. (1963) · Analytical Chemistry · doi:10.1021/ac60205a053 · Cited by 1,525
Peterkofsky, B., & Diegelmann, R. (1971) · Biochemistry · doi:10.1021/bi00782a009 · Cited by 1,379
Neuropsychiatric Disorders Caused by Cobalamin Deficiency in the Absence of Anemia or Macrocytosis
Lindenbaum, J., Healton, E. B., Savage, D. G., Brust, J. C. M., Garrett, T. J., Podell, E. R., Margell, P. D., Stabler, S. P., & Allen, R. H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198806303182604 · Cited by 1,303
Association between Plasma Homocysteine Concentrations and Extracranial Carotid-Artery Stenosis
Selhub, J., Jacques, P. F., Bostom, A. G., D'Agostino, R. B., Wilson, P. W. F., Belanger, A. J., O'Leary, D. H., Wolf, P. A., Schaefer, E. J., & Rosenberg, I. H. (1995) · New England Journal of Medicine · doi:10.1056/nejm199502023320502 · Cited by 1,216
Cited by
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
Decreased Rate of Coronary Restenosis after Lowering of Plasma Homocysteine Levels
Schnyder, G., Roffi, M., Pin, R., Flammer, Y., Lange, H., Eberli, F. R., Meier, B., Turi, Z. G., & Hess, O. M. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011364 · Cited by 532
Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease
Austin, R. C., Lentz, S. R., & Werstuck, G. H. (2004) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401451 · Cited by 414
Current concepts in the pathogenesis of alcoholic liver injury
Tsukamoto, H., & Lu, S. C. (2001) · The FASEB Journal · doi:10.1096/fj.00-0650rev · Cited by 382
Schnyder, G., Roffi, M., Flammer, Y., Pin, R., & Hess, O. M. (2002) · JAMA · doi:10.1001/jama.288.8.973 · Cited by 379
Metadata
- Authors
- Majors, A., Ehrhart, L. A., & Pezacka, E. H.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 1997-10
- Volume
- 17
- Issue
- 10
- Pages
- 2074-2081
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2100367705
- Cited by
- 261
- References
- 55
- FWCI
- 6.83
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Homocysteine as a Risk Factor for Vascular Disease: Enhanced Collagen Production and Accumulation by Smooth Muscle Cells. https://app.cochat.ai/papers/10.1161/01.atv.17.10.2074
- The paper
- Majors, A., Ehrhart, L. A., & Pezacka, E. H. (1997). Homocysteine as a Risk Factor for Vascular Disease: Enhanced Collagen Production and Accumulation by Smooth Muscle Cells. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/01.atv.17.10.2074
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
