The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Human Paraoxonase-3 Is an HDL-Associated Enzyme With Biological Activity Similar to Paraoxonase-1 Protein but Is Not Regulated by Oxidized Lipids
Open accessAbstract
Abstract —Paraoxonase-1 (PON1) is a secreted protein associated primarily with high density lipoprotein (HDL) and participates in the prevention of low density lipoprotein (LDL) oxidation. Two other paraoxonase (PON) family members, namely, PON2 and PON3, have been identified. In this study, we report the cloning and characterization of the human PON3 gene from HepG2 cells. Tissue Northern analysis identifies an ≈1.3-kb transcript for PON3 primarily in the liver. PON3-specific peptide antibodies detect an ≈40-kDa protein associated with HDL and absent from LDL. Pretreatment of cultured human aortic endothelial cells with supernatants from HeLa Tet On cell lines overexpressing PON3 prevents the formation of mildly oxidized LDL and inactivates preformed mildly oxidized LDL. In contrast to PON1, PON3 is not active against the synthetic substrates paraoxon and phenylacetate. Furthermore, PON3 expression is not regulated in HepG2 cells by oxidized phospholipids and is not regulated in the livers of mice fed a high-fat atherogenic diet.
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Watson, A. D., Leitinger, N., Navab, M., Faull, K. F., Hörkkö, S., Witztum, J. L., Palinski, W., Schwenke, D., Salomon, R. G., Sha, W., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.21.13597 · Cited by 753
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Cited by
Antiinflammatory Properties of HDL
Barter, P. J., Nicholls, S., Rye, K.-A., Anantharamaiah, G. M., Navab, M., & Fogelman, A. M. (2004) · Circulation Research · doi:10.1161/01.res.0000146094.59640.13 · Cited by 1,394
Self-citationBhattacharyya, T. (2008) · JAMA · doi:10.1001/jama.299.11.1265 · Cited by 533
Ng, C. J., Wadleigh, D. J., Gangopadhyay, A., Hama, S., Grijalva, V. R., Navab, M., Fogelman, A. M., & Reddy, S. T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105660200 · Cited by 466
Self-citationAviram, M., & Rosenblat, M. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.06.030 · Cited by 434
Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosis
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Metadata
- Authors
- Reddy, S. T., Wadleigh, D. J., Grijalva, V., Ng, C., Hama, S., Gangopadhyay, A., Shih, D. M., Lusis, A. J., Navab, M., & Fogelman, A. M.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2001-04
- Volume
- 21
- Issue
- 4
- Pages
- 542-547
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2107378767
- Cited by
- 370
- References
- 1
- FWCI
- 8.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Reddy, S. T., Wadleigh, D. J., Grijalva, V., Ng, C., Hama, S., Gangopadhyay, A., Shih, D. M., Lusis, A. J., Navab, M., & Fogelman, A. M. (2001). Human Paraoxonase-3 Is an HDL-Associated Enzyme With Biological Activity Similar to Paraoxonase-1 Protein but Is Not Regulated by Oxidized Lipids. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/01.atv.21.4.542
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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