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Cited by 331Adipokines, Inflammation, and Metabolic DiseasesDietary Effects on HealthLipoproteins and Cardiovascular Health

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

Energy Restriction and Weight Loss on Very-Low-Fat Diets Reduce C-Reactive Protein Concentrations in Obese, Healthy Women

Heilbronn, L. K., Noakes, M., Clifton, P. M.·2001·Arteriosclerosis, Thrombosis, and Vascular Biology
DOI 10.1161/01.atv.21.6.968
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Abstract

Abstract —C-reactive protein (CRP) is an inflammatory-response protein that is a strong, independent predictor of cardiovascular mortality. CRP is positively associated with body mass index (BMI). In this study, we investigated the effects of dynamic weight loss on CRP in 83 healthy, obese women (mean BMI, 33.8±0.4 kg/m 2 ; range, 28.2 to 43.8 kg/m 2 ). Subjects were placed on very-low-fat, energy-restricted diets (5700 kJ, 15% fat) for 12 weeks. Weight, waist and hip circumferences, plasma lipids, glucose, and CRP were measured at baseline and after 12 weeks. CRP was positively associated with BMI ( r =0.281, P =0.01) and waist circumference ( r =0.278, P =0.01) but was not related to other atherosclerosis risk factors. BMI was significantly different between groups split above or below the median for CRP (34.8±0.6 kg/m 2 vs 33.0±0.5 kg/m 2 , P =0.02). After 12 weeks, weight loss was 7.9±0.3 kg. CRP was significantly decreased by 26% ( P <0.001), and a correlation was observed between weight loss and the change in CRP ( r =0.309, P =0.005). The variance in the change in CRP was partly explained by initial CRP (13.6%), energy intake (5.4%), and percentage weight loss (4.6%, P =0.001). This study confirms recent observations that BMI is associated with CRP, a marker for low-grade systemic inflammation. Furthermore, we observed that CRP was lowered in proportion to weight loss.

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Crossref · 10.1161/01.atv.21.6.968

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Research works printed but not linked: 10

  1. 10.1161/atvb.19.8.1986 · DOI
  2. 10.1161/atvb.19.4.972 · DOI
  3. 1995, Int J Obes Relat Metab Disord, 1, 67
  4. 2000, J Clin Endocrinol Metab, 85, 3338
  5. 1997, J Clin Endocrinol Metab, 82, 4196
  6. 1996, Am J Epidemiol, 996, 537
  7. 10.1161/circ.98.8.731 · DOI
  8. 10.1161/circ.100.7.713 · DOI
  9. 1999, Int J Obes Relat Metab Disord, 9, 948
  10. 10.1161/circ.100.3.230 · DOI

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Metadata

Authors
Heilbronn, L. K., Noakes, M., & Clifton, P. M.
Affiliations
Commonwealth Scientific and Industrial Research Organisation (AU)
ORCID
Venue
Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2001-06
Volume
21
Issue
6
Pages
968-970
ISSN
  • 1079-5642 (ISSN-L)
  • 1524-4636
DOI
10.1161/01.atv.21.6.968
OpenAlex
W2163805110
Cited by
331
References
18
Citations by year
2026: 1 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 7 · 2018: 4 · 2017: 8 · 2016: 7 · 2015: 11 · 2014: 11 · 2013: 12 · 2012: 17
FWCI
19.59
Type
journal article
Language
en
Open access
closed
Locations
  • Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords
C-reactive protein, very low-fat diet, caloric restriction, weight loss, obesity, body mass index, waist circumference, low-grade inflammation, cardiovascular risk
MeSH terms
Body Constitution, C-Reactive Protein, Energy Intake, Female, Humans, Middle Aged, Obesity, Weight Loss, Body Mass Index, Diet, Fat-Restricted

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