The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Assessment of the Tissue Distribution of Transplanted Human Endothelial Progenitor Cells by Radioactive Labeling
Open accessAbstract
Background— Transplantation of endothelial progenitor cells (EPCs) improves vascularization and left ventricular function after experimental myocardial ischemia. However, tissue distribution of transplanted EPCs has not yet been monitored in living animals. Therefore, we tested whether radioactive labeling allows us to detect injected EPCs. Methods and Results— Human EPCs were isolated from peripheral blood, characterized by expression of endothelial marker proteins, and radioactively labeled with [ 111 In]indium oxine. EPCs (10 6 ) were injected in athymic nude rats 24 hours after myocardial infarction (n=8) or sham operation (n=8). Scintigraphic images were acquired after 1, 24, 48, and 96 hours after EPC injection. Animals were then killed, and specific radioactivity was measured in different tissues. At 24 to 96 hours after intravenous injection of EPCs, ≈70% of the radioactivity was localized in the spleen and liver, with only ≈1% of the radioactivity identified in the heart of sham-operated animals. After myocardial infarction, the heart-to-muscle radioactivity ratio increased significantly, from 1.02±0.19 in sham-operated animals to 2.03±0.37 after intravenous administration of EPCs. Injection of EPCs into the left ventricular cavity increased this ratio profoundly, from 2.69±1.54 in sham-operated animals to 4.70±1.55 ( P <0.05) in rats with myocardial infarction. Immunostaining of cryosections from infarcted hearts confirmed that EPCs homed predominantly to the infarct border zone. Conclusions— Although only a small proportion of radiolabeled EPCs are detected in nonischemic myocardium, myocardial infarction increases homing of transplanted EPCs in vivo profoundly. Radiolabeling might eventually provide an useful tool for monitoring the fate of transplanted progenitor cells and for clinical cell therapy.
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Self-citationTransplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization
Kalka, C., Masuda, H., Takahashi, T., Kalka-Moll, W. M., Silver, M., Kearney, M., Li, T., Isner, J. M., & Asahara, T. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3422 · Cited by 1,863
Therapeutic Potential of Ex Vivo Expanded Endothelial Progenitor Cells for Myocardial Ischemia
Kawamoto, A., Gwon, H.-C., Iwaguro, H., Yamaguchi, J.-I., Uchida, S., Masuda, H., Silver, M., Ma, H., Kearney, M., Isner, J. M., et al. (2001) · Circulation · doi:10.1161/01.cir.103.5.634 · Cited by 1,220
Mobilization of Endothelial Progenitor Cells in Patients With Acute Myocardial Infarction
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Self-citationIwaguro, H., Yamaguchi, J.-I., Kalka, C., Murasawa, S., Masuda, H., Hayashi, S.-I., Silver, M., Li, T., Isner, J. M., & Asahara, T. (2002) · Circulation · doi:10.1161/hc0602.103673 · Cited by 588
Augmentation of Postnatal Neovascularization With Autologous Bone Marrow Transplantation
Shintani, S., Murohara, T., Ikeda, H., Ueno, T., Sasaki, K.-I., Duan, J., & Imaizumi, T. (2001) · Circulation · doi:10.1161/01.cir.103.6.897 · Cited by 460
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Cited by
Paracrine Mechanisms in Adult Stem Cell Signaling and Therapy
Gnecchi, M., Zhang, Z., Ni, A., & Dzau, V. J. (2008) · Circulation Research · doi:10.1161/circresaha.108.176826 · Cited by 2,027
Waterman, R. S., Tomchuck, S. L., Henkle, S. L., & Betancourt, A. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010088 · Cited by 1,238
Monitoring of Bone Marrow Cell Homing Into the Infarcted Human Myocardium
Hofmann, M., Wollert, K. C., Meyer, G. P., Menke, A., Arseniev, L., Hertenstein, B., Ganser, A., Knapp, W. H., & Drexler, H. (2005) · Circulation · doi:10.1161/01.cir.0000163546.27639.aa · Cited by 932
Ding, D.-C., Shyu, W.-C., & Lin, S.-Z. (2011) · Cell Transplantation · doi:10.3727/096368910x · Cited by 894
Unchain my heart: the scientific foundations of cardiac repair
Dimmeler, S., Zeiher, A. M., & Schneider, M. D. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200524283 · Cited by 668
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Metadata
- Authors
- Aicher, A., Brenner, W., Zuhayra, M., Badorff, C., Massoudi, S., Assmus, B., Eckey, T., Henze, E., Zeiher, A. M., & Dimmeler, S.
- Venue
- Circulation
- Published
- 2003-04-29
- Volume
- 107
- Issue
- 16
- Pages
- 2134-2139
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2106764538
- Cited by
- 559
- References
- 21
- FWCI
- 17.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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