The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Estrogen Increases Bone Marrow–Derived Endothelial Progenitor Cell Production and Diminishes Neointima Formation
Abstract
Background— Estrogens improve endothelial function and accelerate reendothelialization after vascular injury via largely unknown mechanisms. Bone marrow–derived endothelial progenitor cells (EPCs) are thought to positively influence endothelialization, vascular repair, and angiogenesis. Methods and Results— In mice subjected to sham operation, ovariectomy, or ovariectomy and estrogen replacement treatment, estrogen deficiency significantly decreased EPCs circulating in the peripheral blood and residing in the bone marrow, as well as EPCs that were in vitro expanded from spleen-derived mononuclear cells. These effects were completely prevented by estrogen replacement. Human women with increased estrogen plasma concentrations also displayed profoundly increased levels of circulating EPCs. Estrogens increase EPC numbers through a decreased apoptosis rate, which is mediated via a caspase-8–dependent pathway. Estrogen deficiency increased neointima formation after carotid artery injury in mice, but this effect was diminished by estrogen replacement therapy. In mice transplanted with green fluorescent protein–positive bone marrow, reendothelialization of injured vessel segments by bone marrow–derived cells was decreased during estrogen deficiency and increased in response to estrogen treatment. Conclusions— Estrogens increase numbers of EPCs by antiapoptotic effects leading to accelerated vascular repair and decreased neointima formation.
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Cites
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Isolation of Putative Progenitor Endothelial Cells for Angiogenesis
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Bone marrow cells regenerate infarcted myocardium
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The Protective Effects of Estrogen on the Cardiovascular System
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Cited by
Endothelial Progenitor Cells: Characterization and Role in Vascular Biology
Urbich, C., & Dimmeler, S. (2004) · Circulation Research · doi:10.1161/01.res.0000137877.89448.78 · Cited by 2,369
Circulating endothelial progenitor cells and cardiovascular outcomes
Werner, N., Kosiol, S., Schiegl, T., Ahlers, P., Walenta, K., Link, A., Böhm, M., & Nickenig, G. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043814 · Cited by 2,048
Self-citationVascular Actions of Estrogens: Functional Implications
Miller, V. M., & Duckles, S. P. (2008) · Pharmacological Reviews · doi:10.1124/pr.107.08002 · Cited by 593
Estrogen and the cardiovascular system
Knowlton, A. A., & Lee, A. R. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.03.007 · Cited by 489
Endothelial progenitor cells: characterization, pathophysiology, and possible clinical relevance
Hristov, M., & Weber, C. (2004) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2004.tb00474.x · Cited by 477
Metadata
- Authors
- Strehlow, K., Werner, N., Berweiler, J., Link, A., Dirnagl, U., Priller, J., Laufs, K., Ghaeni, L., Milosevic, M., Böhm, M., & Nickenig, G.
- Venue
- Circulation
- Published
- 2003-06-24
- Volume
- 107
- Issue
- 24
- Pages
- 3059-3065
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2152424657
- Cited by
- 454
- References
- 30
- FWCI
- 10.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Estrogen Increases Bone Marrow–Derived Endothelial Progenitor Cell Production and Diminishes Neointima Formation. https://app.cochat.ai/papers/10.1161/01.cir.0000077911.81151.30
- The paper
- Strehlow, K., Werner, N., Berweiler, J., Link, A., Dirnagl, U., Priller, J., Laufs, K., Ghaeni, L., Milosevic, M., Böhm, M., & Nickenig, G. (2003). Estrogen Increases Bone Marrow–Derived Endothelial Progenitor Cell Production and Diminishes Neointima Formation. Circulation. https://doi.org/10.1161/01.cir.0000077911.81151.30
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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