The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Aging, Progenitor Cell Exhaustion, and Atherosclerosis
Abstract
Background— Atherosclerosis is largely attributed to chronic vascular injury, as occurs with excess cholesterol; however, the effect of concomitant vascular aging remains unexplained. We hypothesize that the effect of time in atherosclerosis progression is related to obsolescence of endogenous progenitor cells that normally repair and rejuvenate the arteries. Methods and Results— Here we show that chronic treatment with bone marrow–derived progenitor cells from young nonatherosclerotic ApoE −/− mice prevents atherosclerosis progression in ApoE −/− recipients despite persistent hypercholesterolemia. In contrast, treatment with bone marrow cells from older ApoE −/− mice with atherosclerosis is much less effective. Cells with vascular progenitor potential are decreased in the bone marrow of aging ApoE −/− mice, but cells injected from donor mice engraft on recipient arteries in areas at risk for atherosclerotic injury. Conclusions— Our data indicate that progressive progenitor cell deficits may contribute to the development of atherosclerosis.
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1 retracted
Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells
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RetractedThe pathogenesis of atherosclerosis: a perspective for the 1990s
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Circulating endothelial progenitor cells, vascular function, and cardiovascular risk
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Endothelial Cell Senescence in Human Atherosclerosis: Role of Telomere in Endothelial Dysfunction
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Cited by
Endothelial Progenitor Cells: Characterization and Role in Vascular Biology
Urbich, C., & Dimmeler, S. (2004) · Circulation Research · doi:10.1161/01.res.0000137877.89448.78 · Cited by 2,369
Circulating endothelial progenitor cells and cardiovascular outcomes
Werner, N., Kosiol, S., Schiegl, T., Ahlers, P., Walenta, K., Link, A., Böhm, M., & Nickenig, G. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043814 · Cited by 2,048
Ungvari, Z., Tarantini, S., Donato, A. J., Galvan, V., & Csiszar, A. (2018) · Circulation Research · doi:10.1161/circresaha.118.311378 · Cited by 919
Arterial Aging: Is It an Immutable Cardiovascular Risk Factor?
Najjar, S. S., Scuteri, A., & Lakatta, E. G. (2005) · Hypertension · doi:10.1161/01.hyp.0000177474.06749.98 · Cited by 640
Aging of mesenchymal stem cells
SETHE, S., SCUTT, A., & STOLZING, A. (2006) · Ageing Research Reviews · doi:10.1016/j.arr.2005.10.001 · Cited by 614
Metadata
- Authors
- Rauscher, F. M., Goldschmidt-Clermont, P. J., Davis, B. H., Wang, T., Gregg, D., Ramaswami, P., Pippen, A. M., Annex, B. H., Dong, C., & Taylor, D. A.
- Venue
- Circulation
- Published
- 2003-07-29
- Volume
- 108
- Issue
- 4
- Pages
- 457-463
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2127296141
- Cited by
- 674
- References
- 21
- FWCI
- 15.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rauscher, F. M., Goldschmidt-Clermont, P. J., Davis, B. H., Wang, T., Gregg, D., Ramaswami, P., Pippen, A. M., Annex, B. H., Dong, C., & Taylor, D. A. (2003). Aging, Progenitor Cell Exhaustion, and Atherosclerosis. Circulation. https://doi.org/10.1161/01.cir.0000082924.75945.48
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
