The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Time Delay to Treatment and Mortality in Primary Angioplasty for Acute Myocardial Infarction: Every Minute of Delay Counts
Abstract
Background— Although the relationship between mortality and time delay to treatment has been demonstrated in patients with acute ST-segment elevation myocardial infarction (STEMI) treated by thrombolysis, the impact of time delay on prognosis in patients undergoing primary angioplasty has yet to be clarified. The aim of this report was to address the relationship between time to treatment and mortality as a continuous function and to estimate the risk of mortality for each 30-minute delay. Methods and Results— The study population consisted of 1791 patients with STEMI treated by primary angioplasty. The relationship between ischemic time and 1-year mortality was assessed as a continuous function and plotted with a quadratic regression model. The Cox proportional hazards regression model was used to calculate relative risks (for each 30 minutes of delay), adjusted for baseline characteristics related to ischemic time. Variables related to time to treatment were age >70 years ( P <0.0001), female gender ( P =0.004), presence of diabetes mellitus ( P =0.002), and previous revascularization ( P =0.035). Patients with successful reperfusion had a significantly shorter ischemic time ( P =0.006). A total of 103 patients (5.8%) had died at 1-year follow-up. After adjustment for age, gender, diabetes, and previous revascularization, each 30 minutes of delay was associated with a relative risk for 1-year mortality of 1.075 (95% CI 1.008 to 1.15; P =0.041). Conclusions— These results suggest that every minute of delay in primary angioplasty for STEMI affects 1-year mortality, even after adjustment for baseline characteristics. Therefore, all efforts should be made to shorten the total ischemic time, not only for thrombolytic therapy but also for primary angioplasty.
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Cites
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Self-citationTime from symptom onset to treatment and outcomes after thrombolytic therapy
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Cited by
2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction
O'Gara, P. T., Kushner, F. G., Ascheim, D. D., Casey, D. E., Chung, M. K., de Lemos, J. A., Ettinger, S. M., Fang, J. C., Fesmire, F. M., Franklin, B. A., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.11.019 · Cited by 2,625
Antman, E. M., Anbe, D. T., Armstrong, P. W., Bates, E. R., Green, L. A., Hand, M., Hochman, J. S., Krumholz, H. M., Kushner, F. G., Lamas, G. A., et al. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.07.002 · Cited by 1,020
Self-citationHochman, J. S., Sleeper, L. A., Webb, J. G., Dzavik, V., Buller, C. E., Aylward, P., Col, J., White, H. D., & SHOCK Investigators, F. T. (2006) · JAMA · doi:10.1001/jama.295.21.2511 · Cited by 710
Rao, S. V., O’Donoghue, M. L., Ruel, M., Rab, T., Tamis-Holland, J. E., Alexander, J. H., Baber, U., Baker, H., Cohen, M. G., Cruz-Ruiz, M., et al. (2025) · Circulation · doi:10.1161/cir.0000000000001309 · Cited by 625
Early prediction of circulatory failure in the intensive care unit using machine learning
Hyland, S. L., Faltys, M., Hüser, M., Lyu, X., Gumbsch, T., Esteban, C., Bock, C., Horn, M., Moor, M., Rieck, B., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0789-4 · Cited by 477
Metadata
- Authors
- De Luca, G., Suryapranata, H., Ottervanger, J. P., & Antman, E. M.
- Venue
- Circulation
- Published
- 2004-03-16
- Volume
- 109
- Issue
- 10
- Pages
- 1223-1225
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2154421193
- Cited by
- 1,542
- References
- 10
- FWCI
- 40.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Time Delay to Treatment and Mortality in Primary Angioplasty for Acute Myocardial Infarction: Every Minute of Delay Counts. https://app.cochat.ai/papers/10.1161/01.cir.0000121424.76486.20
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- De Luca, G., Suryapranata, H., Ottervanger, J. P., & Antman, E. M. (2004). Time Delay to Treatment and Mortality in Primary Angioplasty for Acute Myocardial Infarction: Every Minute of Delay Counts. Circulation. https://doi.org/10.1161/01.cir.0000121424.76486.20
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
