Elevated Remnant-Like Particle Cholesterol Concentration: A Characteristic Feature of the Atherogenic Lipoprotein Phenotype
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Complete absence of lipolysis, i.e. complete lipoprotein lipase deficiency, results in extreme elevation of large nascent triglyceride-rich lipoproteins without any concomitant increase in remnants; pancreatitis rather than atherosclerotic cardiovascular disease is the major risk.
“The absence of lipolysis (i.e. complete LPL deficiency) results in the extreme elevation of large ‘nascent’ TRL without any concomitant increase in remnants;36,67,68 here, pancreatitis rather than ASCVD is the major risk.”
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References 123 · Cited by 201
Part of this paper’s reference list could not be split into single entries.
Research works printed but not linked: 2
- Criqui MH, Heiss G, Cohn R. Plasma triglyceride level and mortality from cardiovascular disease. N Engl J Med. 1993;328:1220 -1225.
- Nakajima K, Okazaki M, Tanaka A, et al. Separation and determination of remnant-like particles in human serum using monoclonal antibodies to apo B-100 and apo A-I. J Clin Ligand Assay. 1996;19:177-183.
- Authors
- Twickler, T. B., Dallinga-Thie, G. M., Cohn, J. S., & Chapman, M. J.
- Affiliations
- Inserm (FR)
- From the Department of Internal Medicine (T.B.T., G.M.D.-T.), University Medical Center, Utrecht, the Netherlands; Hyperlipidemia and Atherosclerosis Research Laboratory (J.S.C.), Clinical Research Institute of Montreal, Montreal, Quebec, Canada; and Dyslipoproteinemia and Atherosclerosis (T.B.T., M.J.C.), Unit 551 National Institute of Health and Medical Research (INSERM), Hôpital de la Pitié-Salpetrière, Paris, France.
- Venue
- Circulation
- Published
- 2004-04-27
- Volume
- 109
- Issue
- 16
- Pages
- 1918-1925
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2159581689
- Cited by
- 201
- References
- 123
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 12 · 2023: 14 · 2022: 20 · 2021: 11 · 2020: 6 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 3 · 2015: 6 · 2014: 13 · 2013: 7 · 2012: 6
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- remnant-like particle cholesterol, hypertriglyceridemia, dyslipidemia, cardiovascular risk, triglyceride-rich lipoproteins
- MeSH terms
- Hypolipidemic Agents, Arteriosclerosis, Cholesterol, Coronary Disease, Humans, Hyperlipidemias, Lipoproteins, Phenotype, Risk Factors, Triglycerides, Biomarkers, Hydroxymethylglutaryl-CoA Reductase Inhibitors
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