Safety of Statins: Focus on Clinical Pharmacokinetics and Drug Interactions
Open accessAbstract
Statin monotherapy is generally well tolerated, with a low frequency of adverse events. The most important adverse effects associated with statins are myopathy and an asymptomatic increase in hepatic transaminases, both of which occur infrequently. Because statins are prescribed on a long-term basis, however, possible interactions with other drugs deserve particular attention, as many patients will typically receive pharmacological therapy for concomitant conditions during the course of statin treatment. This review summarizes the pharmacokinetic properties of statins and emphasizes their clinically relevant drug interactions.
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Statins are not applicable as single antifungal agents for treatment of IFI because their MICs are about one order of magnitude higher than their maximum achievable concentrations in human serum.
“Statins are not applicable as single antifungal agents for the treatment of IFI because their MICs are much higher (about 1 order of magnitude) than their maximum achievable concentrations in human serum [11,[40][41][42][43][44][45] .”
From Statins as antifungal agents (2011) · cites this paper as [41]
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References 71 · Cited by 578
- Authors
- Bellosta, S., Paoletti, R., & Corsini, A.
- Affiliations
- University of Milan (IT)
- Venue
- Circulation
- Published
- 2004-06-15
- Volume
- 109
- Issue
- 23_suppl_1
- Pages
- III50-7
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2136859326
- Cited by
- 578
- References
- 71
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 14 · 2023: 12 · 2022: 19 · 2021: 15 · 2020: 22 · 2019: 24 · 2018: 15 · 2017: 17 · 2016: 26 · 2015: 45 · 2014: 45 · 2013: 37 · 2012: 29
- FWCI
- 39.60
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Keywords
- statins, drug safety, adverse drug reactions, myopathy, rhabdomyolysis, hepatic transaminases, drug interactions, pharmacokinetics, long-term statin therapy
- MeSH terms
- Binding, Competitive, Biological Availability, Calcium Channel Blockers, Citrus, Cytochrome P-450 Enzyme System, Drug Interactions, Humans, Liver Function Tests, Polymorphism, Genetic, Fenofibrate, Rhabdomyolysis, Gemfibrozil, Polymyositis, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Cytochrome P-450 CYP2D6, Cytochrome P-450 CYP3A, Chemical and Drug Induced Liver Injury, Cytochrome P-450 Enzyme Inhibitors
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