CoChat
Sign Up
Cited by 124Chemokine receptors and signalingRenin-Angiotensin System StudiesCoagulation, Bradykinin, Polyphosphates, and Angioedema

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Angiotensin II Induces Neutrophil Accumulation In Vivo Through Generation and Release of CXC Chemokines

Open access
Nabah, Yafa Naim Abu, Mateo, Teresa, Estellés, Rossana, Mata, Manuel, Zagorski, John, Sarau, Henry, Cortijo, Julio, Morcillo, Esteban J., Jose, Peter J., Sanz, Maria-Jesus·2004·Circulation
DOI 10.1161/01.cir.0000148824.93600.f3
Open this paper in CoChat — free account

Abstract

Background Angiotensin II (Ang II) is implicated in the development of cardiac ischemic disorders in which prominent neutrophil accumulation occurs. Ang II can be generated intravascularly by the renin-angiotensin system or extravascularly by mast cell chymase. In this study, we characterized the ability of Ang II to induce neutrophil accumulation. Methods and results Intraperitoneal administration of Ang II (1 nmol/L) induced significant neutrophil recruitment within 4 hours (13.3+/-2.3x10(6) neutrophils per rat versus 0.7+/-0.5x10(6) in control animals), which disappeared by 24 hours. Maximal levels of CXC chemokines were detected 1 hour after Ang II injection (577+/-224 pmol/L cytokine-inducible neutrophil chemoattractant [CINC]/keratinocyte-derived chemokine [KC] versus 5+/-3, and 281+/-120 pmol/L macrophage inflammatory protein [MIP-2] versus 14+/-6). Intravital microscopy within the rat mesenteric microcirculation showed that the short-term (30 to 60 minutes) leukocyte-endothelial cell interactions induced by Ang II were attenuated by an anti-rat CINC/KC antibody and nearly abolished by the CXCR2 antagonist SB-517785-M. In human umbilical vein endothelial cells (HUVECs) or human pulmonary artery media in culture, Ang II induced interleukin (IL)-8 mRNA expression at 1, 4, and 24 hours and the release of IL-8 at 4 hours through interaction with Ang II type 1 receptors. When HUVECs were pretreated with IL-1 for 24 hours to promote IL-8 storage in Weibel-Palade bodies, the…

Overview

Integrity signals

Registry

Crossref · 10.1161/01.cir.0000148824.93600.f3

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 25 references

Research works printed but not linked: 5

  1. 1990, Eur Heart J, 11, 100
  2. 10.1161/res.57.1.3874008 · DOI
  3. 10.1161/circ.84.1.2060111 · DOI
  4. 1996, Am J Pathol, 148, 1957
  5. 10.1161/circ.102.17.2118 · DOI

Cited by

Sorted by citations

Items 101–124 of 124

Related

See all

Metadata

Authors
Nabah, Y. N. A., Mateo, T., Estellés, R., Mata, M., Zagorski, J., Sarau, H., Cortijo, J., Morcillo, E. J., Jose, P. J., & Sanz, M.-J.
Affiliations
  • Universitat de València (ES)
  • From the Department of Pharmacology (Y.N.A.N., T.M., R.E., M.M., J.C., E.J.M., M.-J.S.), Faculty of Medicine, University of Valencia, Valencia, Spain; the Carolinas Medical Center (J.Z.), Charlotte, NC; GlaxoSmithKline (H.S.), King of Prussia, Pa; the Valencia General Hospital Foundation, General Hospital of Valencia (J.C.), Valencia, Spain; and the Department of Leukocyte Biology (P.J.J.), School of Biomedical Sciences, Imperial College, London, UK.
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2004-12-07
Volume
110
Issue
23
Pages
3581-3586
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.0000148824.93600.f3
OpenAlex
W2136025343
Cited by
124
References
25
Citations by year
2026: 1 · 2025: 3 · 2024: 6 · 2023: 4 · 2022: 10 · 2021: 8 · 2020: 8 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 6 · 2015: 9 · 2014: 6 · 2013: 5 · 2012: 1
FWCI
2.73
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
  • Repository of Digital Objects for Teaching Research and Culture (University of Valencia) (submittedVersion, cc-by-nc)
Funders
  • Ministerio de Educación, Cultura y Deporte (SAF 2002-01482)
  • Generalitat Valenciana
  • Ministerio de Ciencia y Tecnología
Topics
  • Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Health Sciences › Medicine › Hematology › Coagulation, Bradykinin, Polyphosphates, and Angioedema
Keywords
angiotensin II, neutrophil accumulation, CXC chemokines, CXCL2, interleukin-8, CXCR2, leukocyte-endothelium interaction, chymase, renin-angiotensin system, acute myocardial infarction, neutrophil infiltration, interleukin-1, Weibel-Palade bodies, endothelial cells
MeSH terms
Angiotensin II, Animals, Cell Adhesion, Cells, Cultured, Humans, Leukocytes, Male, Mesentery, Microcirculation, Peritoneal Cavity, Pulmonary Artery, RNA, Messenger, Umbilical Cord, Interleukin-8, Rats, Sprague-Dawley, Chemokines, CXC, Neutrophil Infiltration, Endothelial Cells, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review