The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Effect of Intracoronary Recombinant Human Vascular Endothelial Growth Factor on Myocardial Perfusion: Evidence for a Dose-Dependent Effect
Open accessAbstract
Background —Animal models of therapeutic angiogenesis have stimulated development of clinical application in patients with limited options for coronary revascularization. The impact of recombinant human vascular endothelial growth factor (rhVEGF) on myocardial perfusion in humans has not been reported. Methods and Results —Fourteen patients underwent exercise (n=11), dobutamine (n=2), or dipyridamole (n=1) myocardial perfusion single photon emission CT (SPECT) before as well as 30 and 60 days after rhVEGF administration. After uniform processing and display, 2 observers blinded to the timing of the study and dose of rhVEGF reviewed the SPECT images. By a visual, semiquantitative 20-segment scoring method, summed stress scores (SSS) and summed rest scores (SRS) were generated. Although the SSS did not change from baseline to 30 days (21.6 versus 21.5; P =NS), the SRS improved after rhVEGF (13.2 versus 10.4; P <0.05). Stress and rest perfusion improved in >2 segments infrequently in patients treated with low-dose rhVEGF. However, 5 of 6 patients had improvement in >2 segments at rest and stress with the higher rhVEGF doses. Furthermore, although neither the SSS nor the SRS changed in patients treated with the low doses, the SRS decreased in the high-dose rhVEGF patients at 60 days (14.7 versus 10.7; P <0.05). Quantitative analysis was consistent with the visual findings but failed to demonstrate statistical significance. Conclusions —Although not designed to demonstrate rhVEGF efficacy, these phase 1 data support the concept that rhVEGF improves myocardial perfusion at rest and provide evidence of a dose-dependent effect.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Takeshita, S., Zheng, L. P., Brogi, E., Kearney, M., Pu, L. Q., Bunting, S., Ferrara, N., Symes, J. F., & Isner, J. M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117018 · Cited by 1,036
Self-citationIsner, J. M., Pieczek, A., Schainfeld, R., Blair, R., Haley, L., Asahara, T., Rosenfield, K., Razvi, S., Walsh, K., & Symes, J. F. (1996) · The Lancet · doi:10.1016/s0140-6736(96)03361-2 · Cited by 989
Self-citationLosordo, D. W., Vale, P. R., Symes, J. F., Dunnington, C. H., Esakof, D. D., Maysky, M., Ashare, A. B., Lathi, K., & Isner, J. M. (1998) · Circulation · doi:10.1161/01.cir.98.25.2800 · Cited by 987
Self-citationBanai, S., Jaklitsch, M. T., Shou, M., Lazarous, D. F., Scheinowitz, M., Biro, S., Epstein, S. E., & Unger, E. F. (1994) · Circulation · doi:10.1161/01.cir.89.5.2183 · Cited by 596
Berman, D. S., Hachamovitch, R., Kiat, H., Cohen, I., Cabico, J. A., Wang, F. P., Friedman, J. D., Germano, G., Van Train, K., & Diamond, G. A. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00218-s · Cited by 589
The collateral circulation of the heart
Schaper, W., Görge, G., Winkler, B., & Schaper, J. (1988) · Progress in Cardiovascular Diseases · doi:10.1016/0033-0620(88)90011-4 · Cited by 589
Tuder, R. M., Flook, B. E., & Voelkel, N. F. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117858 · Cited by 588
Schumacher, B., Pecher, P., von Specht, B. U., & Stegmann, T. (1998) · Circulation · doi:10.1161/01.cir.97.7.645 · Cited by 531
Tsurumi, Y., Takeshita, S., Chen, D., Kearney, M., Rossow, S. T., Passeri, J., Horowitz, J. R., Symes, J. F., & Isner, J. M. (1996) · Circulation · doi:10.1161/01.cir.94.12.3281 · Cited by 389
Self-citationMack, C. A., Patel, S. R., Schwarz, E. A., Zanzonico, P., Hahn, R. T., Ilercil, A., Devereux, R. B., Goldsmith, S. J., Christian, T. F., Sanborn, T. A., et al. (1998) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(98)70455-6 · Cited by 305
Cited by
VEGF enhances angiogenesis and promotes blood–brain barrier leakage in the ischemic brain
Zhang, Z. G., Zhang, L., Jiang, Q., Zhang, R., Davies, K., Powers, C., Bruggen, N. V., & Chopp, M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9369 · Cited by 1,296
Cao, R., Bråkenhielm, E., Pawliuk, R., Wariaro, D., Post, M. J., Wahlberg, E., Leboulch, P., & Cao, Y. (2003) · Nature Medicine · doi:10.1038/nm848 · Cited by 721
Ren, X., Feng, Y., Guo, J., Wang, H., Li, Q., Yang, J., Hao, X., Lv, J., Ma, N., & Li, W. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00483c · Cited by 573
Wang, Y. (2004) · Brain · doi:10.1093/brain/awh325 · Cited by 221
mRNA-Based Protein Replacement Therapy for the Heart
Magadum, A., Kaur, K., & Zangi, L. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2018.11.018 · Cited by 176
Metadata
- Authors
- Hendel, R. C., Henry, T. D., Rocha-Singh, K., Isner, J. M., Kereiakes, D. J., Giordano, F. J., Simons, M., & Bonow, R. O.
- Venue
- Circulation
- Published
- 2000-01-18
- Volume
- 101
- Issue
- 2
- Pages
- 118-121
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2008591914
- Cited by
- 295
- References
- 12
- FWCI
- 26.59
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Effect of Intracoronary Recombinant Human Vascular Endothelial Growth Factor on Myocardial Perfusion: Evidence for a Dose-Dependent Effect. https://app.cochat.ai/papers/10.1161/01.cir.101.2.118
- The paper
- Hendel, R. C., Henry, T. D., Rocha-Singh, K., Isner, J. M., Kereiakes, D. J., Giordano, F. J., Simons, M., & Bonow, R. O. (2000). Effect of Intracoronary Recombinant Human Vascular Endothelial Growth Factor on Myocardial Perfusion: Evidence for a Dose-Dependent Effect. Circulation. https://doi.org/10.1161/01.cir.101.2.118
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
