Cited by 169Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid MetabolismCerebrovascular and Carotid Artery Diseases

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Functional Blockade of Platelet-Derived Growth Factor Receptor-β but Not of Receptor-α Prevents Vascular Smooth Muscle Cell Accumulation in Fibrous Cap Lesions in Apolipoprotein E–Deficient Mice

Open access

Sano, Hideto, Sudo, Tetsuo, Yokode, Masayuki, Murayama, Toshinori, Kataoka, Hiroshi, Takakura, Nobuyuki, Nishikawa, Satomi, Nishikawa, Shin-Ichi, Kita, Toru·2001·Circulation

DOI 10.1161/01.cir.103.24.2955

Open this paper in CoChat — free account Open PDF

Abstract

Background —The vascular smooth muscle cell (VSMC) is the central cell component involved in the fibroproliferative response in atherogenesis. As the lesion advances, VSMCs migrate from the media into the subendothelial space, thereby forming fibrous plaque lesions. Platelet-derived growth factor (PDGF) has been known to be a potent chemoattractant and mitogen for SMCs, but the pathophysiological role of the 2 PDGF receptors, receptor-α (PDGFR-α) and receptor-β (PDGFR-β) in atherogenesis is poorly understood. To clarify this problem, we prepared antagonistic rat monoclonal antibodies, APA5 and APB5, against murine PDGFR-α and PDGFR-β, respectively. Methods and Results —Apolipoprotein E–deficient mice were fed a high-fat diet containing 0.3% cholesterol from 6 weeks of age and subjected to injection with 1 mg/d IP of either antibody from 12 to 18 weeks every other day. In the mice injected with APB5, the aortic atherosclerotic lesion size and the number of intimal VSMCs were reduced by 67% and 80%, respectively, compared with the control mice injected with irrelevant rat IgG. In contrast, the mice that received APA5 showed only minimal reduction of lesion size, and a large number of VSMCs were observed in the intima. In the intima of advanced lesions, APB5 immunolabeled VSMCs, whereas APA5 could detect VSMCs mainly in the media. Conclusions —These results indicate that PDGFR-β plays a significant role in formation of fibrous atherosclerotic lesions and that regulation of the signal transduction through PDGFR-β could affect atherogenesis in mice.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1161/01.cir.103.24.2955

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,618
Signal transduction by receptors with tyrosine kinase activity
Ullrich, A., & Schlessinger, J. (1990) · Cell · doi:10.1016/0092-8674(90)90801-k · Cited by 5,435
Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
Plump, A. S., Smith, J. D., Hayek, T., Aalto-Setälä, K., Walsh, A., Verstuyft, J. G., Rubin, E. M., & Breslow, J. L. (1992) · Cell · doi:10.1016/0092-8674(92)90362-g · Cited by 2,263
ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.
Nakashima, Y., Plump, A. S., Raines, E. W., Breslow, J. L., & Ross, R. (1994) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.14.1.133 · Cited by 1,693
Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors
Yarden, Y., Escobedo, J. A., Kuang, W.-J., Yang‐Feng, T. L., Daniel, T. O., Tremble, P., Chen, E. Y., Ando, M. E., Harkins, R. N., Francke, U., et al. (1986) · Nature · doi:10.1038/323226a0 · Cited by 1,208
Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.Preprint
Levéen, P., Pekny, M., Gebré‐Medhin, S., Swolin, B., Larsson, E., & Betsholtz, C. (1994) · Genes & Development · doi:10.1101/gad.8.16.1875 · Cited by 1,130
Inhibition of Neointimal Smooth Muscle Accumulation After Angioplasty by an Antibody to PDGF
Ferns, G. A., Raines, E. W., Sprugel, K. H., Motani, A. S., Reidy, M. A., & Ross, R. (1991) · Science · doi:10.1126/science.1653454 · Cited by 1,064
Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.Preprint
Soriano, P. M. (1994) · Genes & Development · doi:10.1101/gad.8.16.1888 · Cited by 988
Quantitative assessment of atherosclerotic lesions in mice
Paigen, B. J., Morrow, A., Holmes, P. A., Mitchell, D., & Williams, R. A. (1987) · Atherosclerosis · doi:10.1016/0021-9150(87)90202-4 · Cited by 951

Show all 31 references

Research works printed but not linked: 7

10.1161/circ.99.13.1740 · DOI
Heldin CH, Ostman A, Ronnstrand L. Signal transduction via platelet-derived growth factor receptors. Biochim Biophys Acta. 1998;1378:F79–F113.
10.1161/circ.99.4.564 · DOI
10.1161/atv91.14.1.8274468 · DOI
10.1161/circ.101.19.2290 · DOI
10.1161/circ.95.3.669 · DOI
10.1161/atvb.19.4.900 · DOI

Sorted by citations

Molecular Regulation of Vascular Smooth Muscle Cell Differentiation in Development and Disease
Owens, G. K., Kumar, M. S., & Wamhoff, B. R. (2004) · Physiological Reviews · doi:10.1152/physrev.00041.2003 · Cited by 3,472
Role of platelet-derived growth factors in physiology and medicinePreprint
Andræ, J., Gallini, R., & Betsholtz, C. (2008) · Genes & Development · doi:10.1101/gad.1653708 · Cited by 2,534
Vascular smooth muscle cells in atherosclerosis
Basatemur, G. L., Jørgensen, H. F., Clarke, M. C. H., Bennett, M. R., & Mallat, Z. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0227-9 · Cited by 1,099
Epigenetic Control of Smooth Muscle Cell Differentiation and Phenotypic Switching in Vascular Development and Disease
Alexander, M. R., & Owens, G. K. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-012110-142315 · Cited by 796
Smooth muscle cell fate and plasticity in atherosclerosis
Allahverdian, S., Chaâbane, C., Boukais, K., Francis, G. A., & Bochaton‐Piallat, M. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy022 · Cited by 513
PDGF and cardiovascular disease
Raines, E. W. (2004) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2004.03.004 · Cited by 496
Characterization of mesendoderm: a diverging point of the definitive endoderm and mesoderm in embryonic stem cell differentiation culture
Tada, S., Era, T., Furusawa, C., Sakurai, H., Nishikawa, S., Kinoshita, M., Nakao, K., Chiba, T., & Nishikawa, S.-I. (2005) · Development · doi:10.1242/dev.02005 · Cited by 456
Self-citation
Functions of Paracrine PDGF Signaling in the Proangiogenic Tumor Stroma Revealed by Pharmacological Targeting
Pietras, K., Pahler, J. C., Bergers, G., & Hanahan, D. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050019 · Cited by 452
Roles of thromboxane A2 and prostacyclin in the development of atherosclerosis in apoE-deficient mice
Kobayashi, T., Tahara, Y., Matsumoto, M., Iguchi, M., Sano, H., Murayama, T., Arai, H., Oida, H., Yurugi-Kobayashi, T., Yamashita, J. K., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200421446 · Cited by 374
Self-citation
Role of Hydrogen Sulfide in the Development of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice
Wang, Y., Zhao, X., Jin, H., Wei, H., Li, W., Bu, D., Tang, X., Ren, Y., Tang, C., & Du, J. (2009) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.179333 · Cited by 307
Intermittent Fasting in Cardiovascular Disorders—An Overview
Malinowski, B., Zalewska, K., Węsierska, A., Sokołowska, M. M., Socha, M., Liczner, G., Pawlak-Osińska, K., & Wiciński, M. (2019) · Nutrients · doi:10.3390/nu11030673 · Cited by 290
Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells
Uemura, A., Ogawa, M., Hirashima, M., Fujiwara, T., Koyama, S., Takagi, H., Honda, Y., Wiegand, S. J., Yancopoulos, G. D., & Nishikawa, S.-I. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15621 · Cited by 282
Self-citation
VEGF-A and FGF-2 synergistically promote neoangiogenesis through enhancement of endogenous PDGF-B–PDGFRβ signaling
Kano, M. R., Morishita, Y., Iwata, C., Iwasaka, S., Watabe, T., Ouchi, Y., Miyazono, K., & Miyazawa, K. (2005) · Journal of Cell Science · doi:10.1242/jcs.02483 · Cited by 283
Plaque Rupture in Humans and Mice
Schwartz, S. M., Galis, Z. S., Rosenfeld, M. E., & Falk, E. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000261709.34878.20 · Cited by 257
The Role of Platelet-Derived Growth Factor Signaling in Healing Myocardial Infarcts
Zymek, P. T., Bujak, M., Chatila, K. F., Cieślak, A., Thakker, G. D., Entman, M. L., & Frangogiannis, N. G. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.07.060 · Cited by 232
PDGF in organ fibrosis
Klinkhammer, B. M., Floege, J., & Boor, P. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.11.008 · Cited by 238
Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells
Uemura, A., Ogawa, M., Hirashima, M., Fujiwara, T., Koyama, S., Takagi, H., Honda, Y., Wiegand, S. J., Yancopoulos, G. D., & Nishikawa, S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215621 · Cited by 226
Self-citation
Circ_Lrp6, a Circular RNA Enriched in Vascular Smooth Muscle Cells, Acts as a Sponge Regulating miRNA-145 Function
Hall, I. F., Climent, M., Quintavalle, M., Farina, F. M., Schorn, T., Zani, S., Carullo, P., Kunderfranco, P., Civilini, E., Condorelli, G., et al. (2019) · Circulation Research · doi:10.1161/circresaha.118.314240 · Cited by 188
Involvement of platelet‐derived growth factor ligands and receptors in tumorigenesis
Heldin, C. ‐., Lennartsson, J., & Westermark, B. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12690 · Cited by 181
Multiple cell types contribute to the atherosclerotic lesion fibrous cap by PDGFRβ and bioenergetic mechanisms
Newman, A. A. C., Serbulea, V., Baylis, R. A., Shankman, L. S., Bradley, X., Alencar, G. F., Owsiany, K. M., Deaton, R. A., Karnewar, S., Shamsuzzaman, S., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-020-00338-8 · Cited by 176
Mouse models of atherosclerosis: a historical perspective and recent advances
Lee, Y. T., Lin, H. Y., Chan, Y. W. F., Li, K. H. C., To, O. T. L., Yan, B. P., Liu, T., Li, G., Wong, W. T., Keung, W., et al. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-016-0402-5 · Cited by 183
Vascular Smooth Muscle Cells in Cerebral Aneurysm Pathogenesis
Starke, R. M., Chalouhi, N., Ding, D., Raper, D. M. S., McKisic, M. S., Owens, G. K., Hasan, D. M., Medel, R., & Dumont, A. S. (2013) · Translational Stroke Research · doi:10.1007/s12975-013-0290-1 · Cited by 161
PDGFRβ signalling regulates local inflammation and synergizes with hypercholesterolaemia to promote atherosclerosis
He, C., Medley, S. C., Hu, T., Hinsdale, M. E., Lupu, F., Virmani, R., & Olson, L. E. (2015) · Nature Communications · doi:10.1038/ncomms8770 · Cited by 150
Imatinib Attenuates Diabetes-Associated Atherosclerosis
Lassila, M., Allen, T. J., Cao, Z., Thallas, V., Jandeleit-Dahm, K. A. M., Candido, R., & Cooper, M. E. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000124105.39900.db · Cited by 142
Interleukin-1β modulates smooth muscle cell phenotype to a distinct inflammatory state relative to PDGF-DD via NF-κB-dependent mechanisms
Alexander, M. R., Murgai, M., Moehle, C. W., & Owens, G. K. (2012) · Physiological Genomics · doi:10.1152/physiolgenomics.00160.2011 · Cited by 137
A G/C Element Mediates Repression of the SM22α Promoter Within Phenotypically Modulated Smooth Muscle Cells in Experimental Atherosclerosis
Wamhoff, B. R., Hoofnagle, M. H., Burns, A., Sinha, S., McDonald, O. G., & Owens, G. K. (2004) · Circulation Research · doi:10.1161/01.res.0000147961.09840.fb · Cited by 137
Targeting non-malignant disorders with tyrosine kinase inhibitors
Grimminger, F., SCHERMULY, R. T., & Ghofrani, H. A. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3297 · Cited by 136
Crosstalk Between Macrophages and Vascular Smooth Muscle Cells in Atherosclerotic Plaque Stability
Yurdagul, A. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.121.316233 · Cited by 138
Platelet-derived growth factor-BB and Ets-1 transcription factor negatively regulate transcription of multiple smooth muscle cell differentiation marker genes
Dandré, F., & Owens, G. K. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00625.2003 · Cited by 125
PDGF-C and PDGF-D signaling in vascular diseases and animal models
Folestad, E. B., Kunath, A., & Wågsäter, D. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.01.005 · Cited by 123
Diverse role of LDL receptor-related protein in the clearance of proteases and in signaling
Strickland, D. K., & Ranganathan, S. (2003) · Journal of Thrombosis and Haemostasis · doi:10.1046/j.1538-7836.2003.00330.x · Cited by 126
Upregulation of intermediate-conductance Ca2+-activated K+channel (IKCa1) mediates phenotypic modulation of coronary smooth muscle
Tharp, D. L., Wamhoff, B. R., Turk, J. R., & Bowles, D. K. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01254.2005 · Cited by 119
Inhibition of the PDGF receptor by red wine flavonoids provides a molecular explanation for the “French paradox”
Rosenkranz, S., Knirel, D., Dietrich, H., Flesch, M., Erdmann, E., & Böhm, M. (2002) · The FASEB Journal · doi:10.1096/fj.02-0207fje · Cited by 106
Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap
Nürnberg, S., Cheng, K. W., Raiesdana, A., Kundu, R. K., Miller, C. L., Kim, J. B., Arora, K., Carcamo‐Orive, I., Xiong, Y., Tellakula, N., et al. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005155 · Cited by 97
Role of cAMP-Phosphodiesterase 1C Signaling in Regulating Growth Factor Receptor Stability, Vascular Smooth Muscle Cell Growth, Migration, and Neointimal Hyperplasia
Cai, Y., Nagel, D. J., Zhou, Q., Cygnar, K. D., Zhao, H., Li, F., Pi, X., Knight, P. A., & Chen, Y. (2015) · Circulation Research · doi:10.1161/circresaha.116.304408 · Cited by 93
Hypoxia Enhances Platelet-derived Growth Factor Signaling in the Pulmonary Vasculature by Down-Regulation of Protein Tyrosine Phosphatases
ten Freyhaus, H., Dagnell, M., Leuchs, M., Vantler, M., Berghausen, E. M., Caglayan, E., Weißmann, N., Dahal, B. K., SCHERMULY, R. T., Östman, A., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200911-1663oc · Cited by 91
Mulberry leaf powder prevents atherosclerosis in apolipoprotein E-deficient mice
Harauma, A., Murayama, T., Ikeyama, K., Sano, H., Arai, H., Takano, R., Kita, T., Hara, S., Kamei, K., & Yokode, M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.04.170 · Cited by 91
Self-citation
Role of Platelet-Derived Growth Factor/Platelet-Derived Growth Factor Receptor Axis in the Trafficking of Circulating Fibrocytes in Pulmonary Fibrosis
Aono, Y., Kishi, M., Yokota, Y., Azuma, M., Kinoshita, K., Takezaki, A., Sato, S., Kawano, H., Kishi, J., Goto, H., et al. (2014) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0455oc · Cited by 91
Urokinase‐induced signaling in human vascular smooth muscle cells is mediated by PDGFR‐β
Kiyan, Y., Kiyan, R. V., Haller, H. G., & Dumler, I. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600669 · Cited by 86
Blockade of Platelet-Derived Growth Factor or Its Receptors Transiently Delays but Does Not Prevent Fibrous Cap Formation in ApoE Null Mice
Kozaki, K., Kaminski, W. E., Tang, J., Hollenbach, S., Lindahl, P., Sullivan, C. M., Yu, J.-C., Abe, K. Y., Martin, P. J., Ross, R., et al. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64415-x · Cited by 89
Eplerenone Attenuates Myocardial Fibrosis in the Angiotensin II-Induced Hypertensive Mouse: Involvement of Tenascin-C Induced by Aldosterone-Mediated Inflammation
Nishioka, T., Suzuki, M., Onishi, K., Takakura, N., Inada, H., Yoshida, T., Hiroe, M., & Imanaka‐Yoshida, K. (2007) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e318033dfd4 · Cited by 85
Self-citation
Fibroblast growth factor (FGF) signaling regulates transforming growth factor beta (TGFβ)-dependent smooth muscle cell phenotype modulation
Chen, P., Qin, L., Li, G., Tellides, G., & Simons, M. (2016) · Scientific Reports · doi:10.1038/srep33407 · Cited by 84
Origins and Properties of Dental, Thymic, and Bone Marrow Mesenchymal Cells and Their Stem Cells
Komada, Y., Yamane, T., Kadota, D., Isono, K., Takakura, N., Hayashi, S., & Yamazaki, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046436 · Cited by 83
Self-citation
Targeting Platelet in Atherosclerosis Plaque Formation: Current Knowledge and Future Perspectives
Wang, L., & Tang, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249760 · Cited by 78
Increased hypercholesterolemia and atherosclerosis in mice lacking both ApoE and leptin receptor
Wu, K. K., Wu, T.-J., Chin, J., Mitnaul, L. J., Hernandez, M., Cai, T., Ren, N., Waters, M. G., Wright, S. D., & Cheng, K. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.01.029 · Cited by 77
Regulation of Mitochondrial Morphology by Positive Feedback Interaction Between PKCδ and Drp1 in Vascular Smooth Muscle Cell
Lim, S., Lee, S., Seo, H., Ham, O., Lee, C., Park, J., Lee, J., Seung, M., Yun, I., Han, S. M., et al. (2014) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25016 · Cited by 77
Modification of PI3K- and MAPK-Dependent Chemotaxis in Aortic Vascular Smooth Muscle Cells by Protein Kinase C βII
Campbell, M., & Trimble, E. R. (2005) · Circulation Research · doi:10.1161/01.res.0000152966.88353.9d · Cited by 71
Mechanisms of fibrous cap formation in atherosclerosis
Alonso-Herranz, L., Albarrán-Juárez, J., & Bentzon, J. F. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1254114 · Cited by 72
Wild-type LRP6 inhibits, whereas atherosclerosis-linked LRP6 R611C increases PDGF-dependent vascular smooth muscle cell proliferation
Keramati, A. R., Singh, R., Lin, A., Faramarzi, S., Ye, Z.-J., Mane, S., Tellides, G., Lifton, R. P., & Mani, A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019443108 · Cited by 69
Desensitization of Platelet-Derived Growth Factor Receptor-β by Oxidized Lipids in Vascular Cells and Atherosclerotic Lesions
Vindis, C., Escargueil‐Blanc, I., Elbaz, M., Marcheix, B., Grazide, M.-H., Uchida, K., Salvayre, R., & Nègre‐Salvayre, A. (2006) · Circulation Research · doi:10.1161/01.res.0000216288.93234.c3 · Cited by 69
Activated platelets trigger an inflammatory response and enhance migration of aortic smooth muscle cells
Maßberg, S., Vogt, F., Dickfeld, T. L., Brand, K., Page, S., & Gawaz, M. (2003) · Thrombosis Research · doi:10.1016/s0049-3848(03)00342-6 · Cited by 69
RhoB Regulates PDGFR-β Trafficking and Signaling in Vascular Smooth Muscle Cells
Huang, M., DuHadaway, J. B., Prendergast, G. C., & Laury‐Kleintop, L. D. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.154211 · Cited by 66
Alcohol and red wine: impact on cardiovascular risk
Böhm, M., Rosenkranz, S., & Laufs, U. (2003) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfg340 · Cited by 65
The synergistic inhibition of atherogenesis in apoE−/− mice between pravastatin and the sPLA2 inhibitor varespladib (A-002)
Shaposhnik, Z., Wang, X., Trias, J., Fraser, H. I., & Lusis, A. J. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800361-jlr200 · Cited by 64
Development of a Fully Human Anti-PDGFRβ Antibody That Suppresses Growth of Human Tumor Xenografts and Enhances Antitumor Activity of an Anti-VEGFR2 Antibody
Shen, J., Vil, M. D., Prewett, M. C., Damoci, C., Zhang, H., Li, H., Jimenez, X., Deevi, D. S., Iacolina, M. D., Kayas, A., et al. (2009) · Neoplasia · doi:10.1593/neo.09278 · Cited by 64
Phosphorylation of the Platelet-derived Growth Factor Receptor-β and Epidermal Growth Factor Receptor by G Protein-coupled Receptor Kinase-2
Freedman, N. J., Kim, L. K., Murray, J. P., Exum, S. T., Brian, L., Wu, J., & Peppel, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204431200 · Cited by 62
Blockade of platelet-derived growth factor receptor-β, not receptor-α ameliorates bleomycin-induced pulmonary fibrosis in mice
Kishi, M., Aono, Y., Sato, S., Koyama, K., Azuma, M., Abe, S., Kawano, H., Kishi, J., Toyoda, Y., Okazaki, H., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0209786 · Cited by 65
Gallic Acid Antagonizes P-Selectin–Mediated Platelet–Leukocyte Interactions
Appeldoorn, C. C. M., Bonnefoy, A., Lutters, B. C. H., Daenens, K., van Berkel, T. J. C., Hoylaerts, M., & Biessen, E. A. L. (2005) · Circulation · doi:10.1161/01.cir.0000151307.10576.02 · Cited by 61
Gallium-68-Labeled Affibody Molecule for PET Imaging of PDGFRβ Expression in Vivo
Strand, J., Varasteh, Z., Eriksson, O., Abrahmsén, L., Orlova, A., & Максимилианович, Т. В. (2014) · Molecular Pharmaceutics · doi:10.1021/mp500284t · Cited by 61
Targeting the PDGF Signaling Pathway in the Treatment of Non-Malignant Diseases
Heldin, C. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9484-2 · Cited by 64
Dynamics of PDGFRβ expression in different cell types after brain injury
Kyyriäinen, J., Ndode‐Ekane, X. E., & Pitkänen, A. (2016) · Glia · doi:10.1002/glia.23094 · Cited by 60
Activation of vascular smooth muscle cells by TNF and PDGF: overlapping and complementary signal transduction mechanisms
Peppel, K., Zhang, L., Orman, E. S., Hagen, P. O., Amalfitano, A., Brian, L., & Freedman, N. J. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.10.031 · Cited by 60
PDGF Receptor and its Antagonists: Role in Treatment of PAH
Grimminger, F., & SCHERMULY, R. T. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-1-60761-500-2_28 · Cited by 61
The pericyte as a cellular regulator of penile erection and a novel therapeutic target for erectile dysfunction
Yin, G. N., Das, N. D., Choi, M. J., Song, K., Kwon, M., Ock, J., Limanjaya, A., Ghatak, K., Kim, W. J., Hyun, J. S., et al. (2015) · Scientific Reports · doi:10.1038/srep10891 · Cited by 55
Activation of STAT3/Smad1 Is a Key Signaling Pathway for Progression to Glomerulosclerosis in Experimental Glomerulonephritis
Takahashi, T., Abe, H., Arai, H., Matsubara, T., Nagai, K., Matsuura, M., Iehara, N., Yokode, M., Nishikawa, S., Kita, T., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411064200 · Cited by 56
Self-citation
Phosphorylation of the Platelet-derived Growth Factor Receptor-β by G Protein-coupled Receptor Kinase-2 Reduces Receptor Signaling and Interaction with the Na+/H+ Exchanger Regulatory Factor
Hildreth, K. L., Wu, J., Barak, L. S., Exum, S. T., Kim, L. K., Peppel, K., & Freedman, N. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403274200 · Cited by 54
RNA modifications in cardiovascular health and disease
Gatsiou, A., & Stellos, K. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00804-8 · Cited by 56
Probing the Virtual Proteome to Identify Novel Disease Biomarkers
Mosley, J. D., Benson, M. D., Smith, J. G., Melander, O., Ngo, D., Shaffer, C. M., Ferguson, J. F., Herzig, M. S., McCarty, C. A., Chute, C. G., et al. (2018) · Circulation · doi:10.1161/circulationaha.118.036063 · Cited by 53
Blockade of Platelet-Derived Growth Factor Receptor-β Pathway Induces Apoptosis of Vascular Endothelial Cells and Disrupts Glomerular Capillary Formation in Neonatal Mice
Sano, H., Ueda, Y., Takakura, N., Takemura, G., Doi, T., Kataoka, H., Murayama, T., Xu, Y. Y., Sudo, T., Nishikawa, S., et al. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64165-x · Cited by 52
Self-citation
Krüppel-like Factor 4 Inhibits Proliferation by Platelet-derived Growth Factor Receptor β-mediated, Not by Retinoic Acid Receptor α-mediated, Phosphatidylinositol 3-Kinase and ERK Signaling in Vascular Smooth Muscle Cells
Zheng, B., Han, M., Bernier, M., Zhang, X., Meng, F., Miao, S., He, M., Zhao, X.-M., & Wen, J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.026989 · Cited by 51
The Intermediate-Conductance Ca2+-Activated K+ Channel (KCa3.1) in Vascular Disease
Tharp, D. L., & Bowles, D. K. (2009) · Cardiovascular & Hematological Agents in Medicinal Chemistry · doi:10.2174/187152509787047649 · Cited by 51
Epac1 Deficiency Attenuated Vascular Smooth Muscle Cell Migration and Neointimal Formation
Kato, Y., Yokoyama, U., Yanai, C., Ishige, R., Kurotaki, D., Umemura, M., Fujita, T., Kubota, T., Okumura, S., Sata, M., et al. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.306534 · Cited by 49
micro RNA let‐7g suppresses PDGF ‐induced conversion of vascular smooth muscle cell into the synthetic phenotype
Wang, T., Chen, K., Hsu, P., Lin, H., Wang, Y., Chen, C., Liao, Y., & Juo, S. H. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13269 · Cited by 50
PDGF-BB/KLF4/VEGF Signaling Axis in Pulmonary Artery Endothelial Cell Angiogenesis
Liang, S., Yu, H., Chen, X., Shen, T., Cui, Z., Zhang, J., Cheng, Y., Jia, S., Song, S., Zhang, X., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000475652 · Cited by 47
Retracted
Immunoglobulin treatment suppresses atherosclerosis in apolipoprotein E-deficient mice via the Fc portion
Yuan, Z., Kishimoto, C., Sano, H., Shioji, K., Xu, Y. Y., & Yokode, M. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00926.2002 · Cited by 47
Self-citation
Role of Bone Marrow–Derived Progenitor Cells in Cuff-Induced Vascular Injury in Mice
Xu, Y. Y., Arai, H., Zhuge, X., Sano, H., Murayama, T., Yoshimoto, M., Heike, T., Nakahata, T., Nishikawa, S., Kita, T., et al. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000118016.94368.35 · Cited by 46
Self-citation
Platelet-Derived Growth Factor-B (PDGF-B) Induced by Hypoxia Promotes the Survival of Pulmonary Arterial Endothelial Cells through the PI3K/Akt/Stat3 Pathway
Li, L., Xu, M., Li, X., Lv, C., Zhang, X., Yu, H., Zhang, M., Fu, Y., Meng, H., & Zhou, J. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000369709 · Cited by 44
Inhibition of Fibroblast Growth Factor Receptor Signaling Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice
Raj, T., Kanellakis, P., Pomilio, G., Jennings, G., Bobik, A., & Agrotis, A. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000227689.41288.5e · Cited by 44
Sp1, acetylated histone‐3 and p300 regulate TRAIL transcription: Mechanisms of PDGF‐BB‐mediated VSMC proliferation and migration
Azahri, N. S. M., Bartolo, B. A. D., Khachigian, L. M., & Kavurma, M. M. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24135 · Cited by 43
Regulation of smooth muscle cells in development and vascular disease: current therapeutic strategies
Cai, X. (2006) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.4.6.789 · Cited by 43
An antibody directed against PDGF receptor β enhances the antitumor and the anti-angiogenic activities of an anti-VEGF receptor 2 antibody
Shen, J., Vil, M. D., Zhang, H., Tonra, J. R., Rong, L., Damoci, C., Prewett, M. C., Deevi, D. S., Kearney, J. A., Surguladze, D., et al. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.04.075 · Cited by 39
Inflammatory crosstalk impairs phagocytic receptors and aggravates atherosclerosis in clonal hematopoiesis in mice
Liu, W., Hardaway, B. D., Kim, E., Pauli, J., Wettich, J. L., Yalçınkaya, M., Hsu, C.-C., Xiao, T., Reilly, M. P., Tabas, I. A., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci182939 · Cited by 37
Research progress on the role of PDGF/PDGFR in type 2 diabetes
Cao, Z., Liu, Y., Wang, Y., & Leng, P. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114983 · Cited by 40
The role of Wnt signalling in development of coronary artery disease and its risk factors
Liu, Y., Neogi, A., & Mani, A. (2020) · Open Biology · doi:10.1098/rsob.200128 · Cited by 38
Regulation of the Platelet-derived Growth Factor Receptor-β by G Protein-coupled Receptor Kinase-5 in Vascular Smooth Muscle Cells Involves the Phosphatase Shp2
Wu, J., Goswami, R., Cai, X., Exum, S. T., Huang, X., Zhang, L., Brian, L., Premont, R. T., Peppel, K., & Freedman, N. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605756200 · Cited by 38
Lipid oxidation products and oxidized low-density lipoproteins impair platelet-derived growth factor receptor activity in smooth muscle cells: implication in atherosclerosis
Vindis, C., Escargueil‐Blanc, I., Uchida, K., Elbaz, M., Salvayre, R., & Nègre‐Salvayre, A. (2007) · Redox Report · doi:10.1179/135100007x162248 · Cited by 37
Role of advanced glycation end products on vascular smooth muscle cells under diabetic atherosclerosis
Mao, L., Yin, R., Yang, L., & Zhao, D. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.983723 · Cited by 42
Gene expression profiling of non‐alcoholic steatohepatitis using gene set enrichment analysis
Yoneda, M., Endo, H., Mawatari, H., Nozaki, Y., Fujita, K., Akiyama, T., Higurashi, T., Uchiyama, T., Yoneda, K., Takahashi, H., et al. (2008) · Hepatology Research · doi:10.1111/j.1872-034x.2008.00399.x · Cited by 35
The interplay of canonical and noncanonical Wnt signaling in metabolic syndrome
Ziki, M. D. A., & Mani, A. (2018) · Nutrition Research · doi:10.1016/j.nutres.2018.06.009 · Cited by 34
Overexpression of G Protein-Coupled Receptor Kinase-2 in Smooth Muscle Cells Reduces Neointimal Hyperplasia
Peppel, K., Zhang, L., Huynh, T. T., Huang, X., Jacobson, A., Brian, L., Exum, S. T., Hagen, P., & Freedman, N. J. (2002) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2002.2092 · Cited by 34
The Platelet-derived Growth Factor Receptor-β Phosphorylates and Activates G Protein-coupled Receptor Kinase-2
Wu, J., Goswami, R., Kim, L. K., Miller, W. E., Peppel, K., & Freedman, N. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501473200 · Cited by 31
Tissue plasminogen activator disrupts the blood-brain barrier through increasing the inflammatory response mediated by pericytes after cerebral ischemia
Yang, E., Cai, Y., Yao, X., Liu, J., Wang, Q., Jin, W., Wu, Q., Fan, W., Qiu, L., Kang, C., et al. (2019) · Aging · doi:10.18632/aging.102431 · Cited by 30
Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells
Uemura, A., Ogawa, M., Hirashima, M., Fujiwara, T., Koyama, S., Takagi, H., Honda, Y., Wiegand, S. J., Yancopoulos, G. D., & Nishikawa, S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200215621 · Cited by 30
Self-citation
YAP1/TEAD1 upregulate platelet-derived growth factor receptor beta to promote vascular smooth muscle cell proliferation and neointima formation
Osman, I., Dong, K., Kang, X., Yu, L., Xu, F., Ahmed, A. S. I., He, X., Shen, J., Hu, G., Zhang, W., et al. (2021) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2021.03.005 · Cited by 29
Platelet-derived growth factor receptor inhibition reduces allograft arteriosclerosis of heart and aorta in cholesterol-fed rabbits
Sihvola, R. K., Tikkanen, J., Krebs, R., Sutinen, E., Buchdunger, E., Laitinen, O., Koskinen, P., & Lemström, K. (2003) · Transplantation · doi:10.1097/01.tp.0000045056.82561.0f · Cited by 27
Cellular metabolism changes in atherosclerosis and the impact of comorbidities
Dai, Y., Junho, C. V. C., Schieren, L., Wollenhaupt, J., Sluimer, J. C., van der Vorst, E. P. C., & Noels, H. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1446964 · Cited by 27
Distribution of microsomal prostaglandin E synthase‐1 in the mouse brain
Eskilsson, A., Tachikawa, M., Hosoya, K., & Blomqvist, A. G. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23593 · Cited by 25
The Matricellular Protein Cyr61 Is a Key Mediator of Platelet-derived Growth Factor-induced Cell Migration
Zhang, F., Feng, H., An, D., Zeng, L., Wáng, Y., Xu, X., & Cui, M. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.623074 · Cited by 26
Taurine suppresses platelet-derived growth factor (PDGF) BB-induced PDGF-β receptor phosphorylation by protein tyrosine phosphatase-mediated dephosphorylation in vascular smooth muscle cells
Yoshimura, H., Nariai, Y., Terashima, M., Mitani, T., & Tanigawa, Y. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2005.07.005 · Cited by 25
Blocking Properdin Prevents Complement-Mediated Hemolytic Uremic Syndrome and Systemic Thrombophilia
Ueda, Y., Miwa, T., Gullipalli, D., Sato, S., Ito, D., Kim, H., Palmer, M., & Song, W. (2018) · Journal of the American Society of Nephrology · doi:10.1681/asn.2017121244 · Cited by 25

Authors: Sano, H., Sudo, T., Yokode, M., Murayama, T., Kataoka, H., Takakura, N., Nishikawa, S., Nishikawa, S.-I., & Kita, T.
Affiliations: Kyoto University (JP)
ORCID: Sano, Hideto
Murayama, Toshinori
Kataoka, Hiroshi
Takakura, Nobuyuki
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2001-06-19
Volume: 103
Issue: 24
Pages: 2955-2960
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.103.24.2955
OpenAlex: W1963798186
Cited by: 169
References: 31
Citations by year: 2025: 4 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 8 · 2020: 4 · 2019: 5 · 2018: 9 · 2017: 6 · 2016: 6 · 2015: 10 · 2014: 4 · 2013: 4 · 2012: 4
FWCI: 3.56
Type: journal article
Language: en
Open access: green
hdl.handle.net
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Kyoto University Research Information Repository (Kyoto University) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cerebrovascular and Carotid Artery Diseases
Keywords: platelet-derived growth factor, PDGF receptor beta, PDGF receptor alpha, vascular smooth muscle cells, atherosclerosis, fibrous cap, intimal thickening, monoclonal antibodies, ApoE-deficient mice, high-fat diet, VSMC migration, atherogenesis
MeSH terms: Animals, Antibodies, Monoclonal, Aorta, Apolipoproteins E, Arteriosclerosis, Bone Marrow Cells, Cell Count, Cells, Cultured, Colony-Forming Units Assay, Diet, Atherogenic, Disease Models, Animal, Fibrosis, Immunohistochemistry, Injections, Intraperitoneal, Muscle, Smooth, Vascular, Sinus of Valsalva, Signal Transduction, Rats, Wistar, Mice, Knockout, Disease Progression, Receptor, Platelet-Derived Growth Factor alpha, Receptor, Platelet-Derived Growth Factor beta, Mice, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Functional Blockade of Platelet-Derived Growth Factor Receptor-β but Not of Receptor-α Prevents Vascular Smooth Muscle Cell Accumulation in Fibrous Cap Lesions in Apolipoprotein E–Deficient Mice

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks