The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Structural Abnormalities of Great Arterial Walls in Congenital Heart Disease: Light and Electron Microscopic Analyses
Abstract
Background —Great arteries in congenital heart disease (CHD) may dilate, become aneurysmal, or rupture. Little is known about medial abnormalities in these arterial walls. Accordingly, we studied 18 types of CHD in patients from neonates to older adults. Methods and Results —Intraoperative biopsies from ascending aorta, paracoarctation aorta, truncus arteriosus, and pulmonary trunk in 86 patients were supplemented by 16 necropsy specimens. The 102 patients were 3 weeks to 81 years old (average, 32±6 years). Biopsies were examined by light (LM) and electron (EM) microscopy; necropsy specimens by LM. Positive aortic controls were from 15 Marfan patients. Negative aortic controls were from 11 coronary artery disease patients and 1 transplant donor. Nine biopsies from acquired trileaflet aortic stenosis were compared with biopsies from bicuspid aortic stenosis. Negative pulmonary trunk controls were from 7 coronary artery disease patients. A grading system consisted of negative controls and grades 1, 2, and 3 (positive controls) based on LM and EM examination of medial constituents. Conclusions —Medial abnormalities in ascending aorta, paracoarctation aorta, truncus arteriosus, and pulmonary trunk were prevalent in patients with a variety of forms of CHD encompassing a wide age range. Aortic abnormalities may predispose to dilatation, aneurysm, and rupture. Pulmonary trunk abnormalities may predispose to dilatation and aneurysm; hypertensive aneurysms may rupture. Pivotal questions are whether these abnormalities are inherent or acquired, whether CHD plays a causal or facilitating role, and whether genetic determinants are operative.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Histologic changes in the normal aging aorta: Implications for dissecting aortic aneurysm
Schlatmann, T. J. M., & Becker, A. E. (1977) · The American Journal of Cardiology · doi:10.1016/s0002-9149(77)80004-0 · Cited by 537
Mutations in the human gene for fibrillin-1 (FBN1) in the Marfan syndrome and related disorders
Dietz, H., & Pyeritz, R. (1995) · Human Molecular Genetics · doi:10.1093/hmg/4.suppl_1.1799 · Cited by 483
Sabet, H. Y., Edwards, W. D., Tazelaar, H. D., & Daly, R. C. (1999) · Mayo Clinic Proceedings · doi:10.4065/74.1.14 · Cited by 416
Hahn, R. T., Roman, M. J., Mogtadek, A. H., & Devereux, R. B. (1992) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(92)90479-7 · Cited by 406
Mechanisms Underlying Aortic Dilatation in Congenital Aortic Valve Malformation
Bonderman, D., Gharehbaghi-Schnell, E., Wollenek, G., Maurer, G., Baumgartner, H., & Lang, I. M. (1999) · Circulation · doi:10.1161/01.cir.99.16.2138 · Cited by 316
Medionecrosis aortae idiopathica cystica
Roberts, J. T. (1939) · American Heart Journal · doi:10.1016/s0002-8703(39)90765-9 · Cited by 261
Medionecrosis aortae idiopathica cystica
Erdheim, J. (1930) · Virchows Archiv für Pathologische Anatomie und Physiologie und für Klinische Medizin · doi:10.1007/bf02275142 · Cited by 231
Segura, A. M., Luna, R. E., Horiba, K., Stetler‐Stevenson, W. G., McAllister, H. A., Willerson, J. T., & Ferrans, V. J. (1998) · PubMed · Cited by 218
Effect of Vasa Vasorum Flow on Structure and Function of the Aorta in Experimental Animals
Stefanadis, C., Vlachopoulos, C., Karayannacos, P., Boudoulas, H., Stratos, C., Filippides, T., Agapitos, M., & Toutouzas, P. (1995) · Circulation · doi:10.1161/01.cir.91.10.2669 · Cited by 211
Eisenmenger syndrome in adults
Niwa, K., Perloff, J. K., Kaplan, S., Child, J. S., & Miner, P. D. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00153-9 · Cited by 194
Self-citation
Cited by
ESC Guidelines for the management of grown-up congenital heart disease (new version 2010)
Endorsed by the Association for European Paediatric Cardiology (AEPC), Authors/Task Force Members, Baumgartner, H., Bonhoeffer, P., De Groot, N. M. S., de Haan, F., Deanfield, J. E., Galie, N., Gatzoulis, M. A., Gohlke-Baerwolf, C., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq249 · Cited by 2,331
ACC/AHA 2008 Guidelines for the Management of Adults With Congenital Heart Disease
Warnes, C. A., Williams, R. G., Bashore, T. M., Child, J. S., Connolly, H. M., Dearani, J. A., del Nido, P., Fasules, J. W., Graham, T. P., Hijazi, Z. M., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.10.001 · Cited by 1,533
Self-citationSiu, S. C., & Silversides, C. K. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.12.068 · Cited by 1,028
Michelena, H. I., Prakash, S. K., Della Corte, A., Bissell, M. M., Anavekar, N., Mathieu, P., Bossé, Y., Limongelli, G., Bossone, E., Benson, D. W., et al. (2014) · Circulation · doi:10.1161/circulationaha.113.007851 · Cited by 442
Fedak, P. W. M., de Sa, M. P. L., Verma, S., Nili, N., Kazemian, P., Butany, J., Strauss, B. H., Weisel, R. D., & David, T. E. (2003) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(03)00398-2 · Cited by 438
Metadata
- Authors
- Niwa, K., Perloff, J. K., Bhuta, S. M., Laks, H., Drinkwater, D. C., Child, J. S., & Miner, P. D.
- Venue
- Circulation
- Published
- 2001-01-23
- Volume
- 103
- Issue
- 3
- Pages
- 393-400
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1988420746
- Cited by
- 573
- References
- 16
- FWCI
- 11.41
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Structural Abnormalities of Great Arterial Walls in Congenital Heart Disease: Light and Electron Microscopic Analyses. https://app.cochat.ai/papers/10.1161/01.cir.103.3.393
- The paper
- Niwa, K., Perloff, J. K., Bhuta, S. M., Laks, H., Drinkwater, D. C., Child, J. S., & Miner, P. D. (2001). Structural Abnormalities of Great Arterial Walls in Congenital Heart Disease: Light and Electron Microscopic Analyses. Circulation. https://doi.org/10.1161/01.cir.103.3.393
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
