The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Results of Targeted Anti–Tumor Necrosis Factor Therapy With Etanercept (ENBREL) in Patients With Advanced Heart Failure
Abstract
Background —Previously, we showed that tumor necrosis factor (TNF) antagonism with etanercept, a soluble TNF receptor, was well tolerated and that it suppressed circulating levels of biologically active TNF for 14 days in patients with moderate heart failure. However, the effects of sustained TNF antagonism in heart failure are not known. Methods and Results —We conducted a randomized, double-blind, placebo-controlled, multidose trial of etanercept in 47 patients with NYHA class III to IV heart failure. Patients were treated with biweekly subcutaneous injections of etanercept 5 mg/m 2 (n=16) or 12 mg/m 2 (n=15) or with placebo (n=16) for 3 months. Doses of 5 and 12 mg/m 2 etanercept were safe and well tolerated for 3 months. Treatment with etanercept led to a significant dose-dependent improvement in left ventricular (LV) ejection fraction and LV remodeling, and there was a trend toward an improvement in patient functional status, as determined by clinical composite score. Conclusion —Treatment with etanercept for 3 months was safe and well-tolerated in patients with advanced heart failure, and it resulted in a significant dose-dependent improvement in LV structure and function and a trend toward improvement in patient functional status.
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Bozkurt, B., Kribbs, S. B., Clubb, F. J., Michael, L. H., Didenko, V. V., Hornsby, P. J., Seta, Y., Oral, H., Spinale, F. G., & Mann, D. L. (1998) · Circulation · doi:10.1161/01.cir.97.14.1382 · Cited by 821
Self-citationDeswal, A., Bozkurt, B., Seta, Y., Parilti-Eiswirth, S., Hayes, F. A., Blosch, C., & Mann, D. L. (1999) · Circulation · doi:10.1161/01.cir.99.25.3224 · Cited by 393
Self-citationSliwa, K., Skudicky, D., Candy, G., Wisenbaugh, T., & Sareli, P. (1998) · The Lancet · doi:10.1016/s0140-6736(97)09338-0 · Cited by 216
Kubota, T., Bounoutas, G. S., Miyagishima, M., Kadokami, T., Sanders, V. J., Bruton, C., Robbins, P. D., McTiernan, C. F., & Feldman, A. M. (2000) · Circulation · doi:10.1161/01.cir.101.21.2518 · Cited by 160
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Chung, E. S., Packer, M., Lo, K. H., Fasanmade, A. A., & Willerson, J. T. (2003) · Circulation · doi:10.1161/01.cir.0000077913.60364.d2 · Cited by 1,644
Mann, D. L., McMurray, J. J. V., Packer, M., Swedberg, K., Borer, J. S., Colucci, W. S., Djian, J., Drexler, H., Feldman, A., Kober, L., et al. (2004) · Circulation · doi:10.1161/01.cir.0000124490.27666.b2 · Cited by 1,240
Self-citationInflammatory Mediators and the Failing Heart: Past, Present, and the Foreseeable Future
Mann, D. L. (2002) · Circulation Research · doi:10.1161/01.res.0000043825.01705.1b · Cited by 988
Self-citationCachexia: pathophysiology and clinical relevance1,2
Morley, J. E., Thomas, D. R., & Wilson, M.-M. G. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.4.735 · Cited by 786
Guidelines of care for the management of psoriasis and psoriatic arthritis
Gottlieb, A., Korman, N. J., Gordon, K. B., Feldman, S. R., Lebwohl, M., Koo, J. Y. M., Van Voorhees, A. S., Elmets, C. A., Leonardi, C. L., Beutner, K. R., et al. (2008) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2008.02.040 · Cited by 769
Metadata
- Authors
- Bozkurt, B., Torre-Amione, G., Warren, M. S., Whitmore, J., Soran, O. Z., Feldman, A. M., & Mann, D. L.
- Venue
- Circulation
- Published
- 2001-02-27
- Volume
- 103
- Issue
- 8
- Pages
- 1044-1047
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2041657104
- Cited by
- 388
- References
- 4
- FWCI
- 28.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Results of Targeted Anti–Tumor Necrosis Factor Therapy With Etanercept (ENBREL) in Patients With Advanced Heart Failure. https://app.cochat.ai/papers/10.1161/01.cir.103.8.1044
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- Bozkurt, B., Torre-Amione, G., Warren, M. S., Whitmore, J., Soran, O. Z., Feldman, A. M., & Mann, D. L. (2001). Results of Targeted Anti–Tumor Necrosis Factor Therapy With Etanercept (ENBREL) in Patients With Advanced Heart Failure. Circulation. https://doi.org/10.1161/01.cir.103.8.1044
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
