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Cited by 279

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Relation of Electrolyte Disturbances to Cardiac Arrhythmias

Open access
FISCH, CHARLES·1973·Circulation
DOI 10.1161/01.cir.47.2.408
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Abstract

While a number of electrolytes play a role in the genesis of the transmembrane action potential (AP), the changes in the action potential most clearly related to arrhythmias are dependent to a large extent on K + . Potassium gradient is a major determinant of the magnitude of transmembrane resting potential (TRP), and secondarily the rate of rise (dV/dt) of phase 0, and consequently the speed of conduction. The cell membrane conductance for K + , or a decrease therein, is most likely the major determinant of spontaneous slow depolarization during phase 4. Thus K + has a pronounced effect on both conduction and automaticity. Furthermore, these electrophysiologic properties are altered within levels of K + encountered in clinical medicine, a situation which, with rare exceptions, is not seen with Ca ++ , Mg ++ , or Na – . These latter ions affect the action potential and induce experimental arrhythmias at concentrations which are unphysiologic and frequently incompatible with life. Consequently, of all the electrolytes, disturbed K + metabolism accounts for the vast majority of clinical arrhythmias. For the same reasons, with the exception of the ability of Na + and Ca ++ to reverse the K + -induced depression of conduction, K + is the only electrolyte with clinacally significant antiarrhythmic properties.

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Metadata

Authors
FISCH, C.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1973-02
Volume
47
Issue
2
Pages
408-419
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.47.2.408
OpenAlex
W1988086452
Cited by
279
References
12
FWCI
6.16
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Relation of Electrolyte Disturbances to Cardiac Arrhythmias. https://app.cochat.ai/papers/10.1161/01.cir.47.2.408
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FISCH, C. (1973). Relation of Electrolyte Disturbances to Cardiac Arrhythmias. Circulation. https://doi.org/10.1161/01.cir.47.2.408

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.