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Effect of Digitalis on Atrioventricular Conduction and Circus-Movement Tachycardias in Patients with Wolff-Parkinson-White Syndrome
Open accessAbstract
During regular driving of the right atrium using the single-test stimulus method, atrioventricular conduction and initiation of tachycardias were studied in six patients with the Wolff-Parkinson-White syndrome (W-P-W), before and 45 min after the administration of ouabain (0.75-1.5 mg into the right atrium). Following ouabain (1) all patients showed shortening of the refractory period of their anomalous pathway; (2) at least five of them showed lengthening of the refractory period of the A-V nodal-His pathway; and (3) all patients showed prolongation of the A-V nodal transmission time (prolongation of the A-H interval). In four patients who suffered from circus-movement tachycardias these changes resulted in two patients in marked shortening of the range of premature beat intervals during which a tachycardia could be initiated and complete inability to initiate a tachycardia in the other two. These results suggest that digitalis can be of prophylactive value in patients with the Wolff-Parkinson-White syndrome and circus-movement tachycardias.
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Citations
Cited by
Ventricular fibrillation in the Wolff-Parkinson-White syndrome
Klein, G. J., Bashore, T. M., Sellers, T. D., Pritchett, E. L. C., Smith, W. M., & Gallagher, J. J. (1979) · New England Journal of Medicine · doi:10.1056/nejm197911153012003 · Cited by 830
Verapamil: A Review of its Pharmacological Properties and Therapeutic Use1
Singh, B. N., Ellrodt, G., & Peter, C. T. (1978) · Drugs · doi:10.2165/00003495-197815030-00001 · Cited by 832
Gallagher, J. J., Pritchett, E. L. C., Sealy, W. C., Kasell, J., & Wallace, A. G. (1978) · Progress in Cardiovascular Diseases · doi:10.1016/0033-0620(78)90015-4 · Cited by 757
Page, R. L., Joglar, J. A., Caldwell, M. A., Calkins, H., Conti, J. B., Deal, B. J., Estes, N. A. M., Field, M. E., Goldberger, Z. D., Hammill, S. C., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000311 · Cited by 595
2015 ACC/AHA/HRS Guideline for the Management of Adult Patients With Supraventricular Tachycardia
Page, R. L., Joglar, J. A., Caldwell, M. A., Calkins, H., Conti, J. B., Deal, B. J., Estes, N. A. M., Field, M. E., Goldberger, Z. D., Hammill, S. C., et al. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.08.856 · Cited by 439
Metadata
- Authors
- WELLENS, H. J., & DURRER, D.
- Venue
- Circulation
- Published
- 1973-06
- Volume
- 47
- Issue
- 6
- Pages
- 1229-1233
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2094692726
- Cited by
- 176
- References
- 0
- FWCI
- 13.75
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Effect of Digitalis on Atrioventricular Conduction and Circus-Movement Tachycardias in Patients with Wolff-Parkinson-White Syndrome. https://app.cochat.ai/papers/10.1161/01.cir.47.6.1229
- The paper
- WELLENS, H. J., & DURRER, D. (1973). Effect of Digitalis on Atrioventricular Conduction and Circus-Movement Tachycardias in Patients with Wolff-Parkinson-White Syndrome. Circulation. https://doi.org/10.1161/01.cir.47.6.1229
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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